Protein: SLX1
Structure-specific endonuclease subunit SLX1 (EC 3.1.-.-) (GIY-YIG domain-containing protein 1)

Gene: SLX1, SLX1A
Organism: Homo sapiens
Interactions: 71
UniProt ID: Q9BQ83

Gene Ontology (top 5):
GO:0000724 - double-strand break repair via homologous recombination
GO:0005654 - nucleoplasm
GO:0006281 - DNA repair
GO:0008270 - zinc ion binding
GO:0008821 - crossover junction DNA endonuclease activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1314384

SLX4
Structure-specific endonuclease subunit SLX4

9

1

Small-scale

0.976

High

1369961

XPF
DNA repair endonuclease XPF

3

0

Small-scale

0.647

High

1399305

MUS81
Structure-specific endonuclease subunit MUS81

3

0

Small-scale

0.645

High

464394

ERCC1
DNA excision repair protein ERCC-1

3

0

Small-scale

0.642

High

1153787

NCOA1
Nuclear receptor coactivator 1

2

1

High-throughput

0.628

High

166556

BACH1
Transcription regulator protein BACH1

2

0

High-throughput

0.602

High

693357

ARNT
Aryl hydrocarbon receptor nuclear translocator

2

0

High-throughput

0.602

High

1106446

TOP3A
DNA topoisomerase 3-alpha

2

0

High-throughput

0.602

High

1134877

PSME4
Proteasome activator complex subunit 4

2

0

High-throughput

0.602

High

920238

PLK1
Serine/threonine-protein kinase PLK1

2

1

High-throughput

0.601

High

1383751

EME1
Structure-specific endonuclease subunit EME1

2

0

Small-scale

0.592

High

1410232

SLX1
Structure-specific endonuclease subunit SLX1

1

0

High-throughput

0.586

High

276341

HMMR
Hyaluronan mediated motility receptor

2

1

High-throughput

0.574

High

1216022

M3K21
Mitogen-activated protein kinase kinase kinase 21

2

1

High-throughput

0.574

High

128055

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

1

High-throughput

0.536

High

165403

PSA7
Proteasome subunit alpha type-7

1

4

High-throughput

0.536

High

633781

PSB1
Proteasome subunit beta type-1

1

7

High-throughput

0.536

High

651860

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

1

High-throughput

0.536

High

681001

PSA1
Proteasome subunit alpha type-1

1

4

High-throughput

0.536

High

681222

PSA2
Proteasome subunit alpha type-2

1

5

High-throughput

0.536

High

681498

PSA3
Proteasome subunit alpha type-3

1

4

High-throughput

0.536

High

681708

PSA4
Proteasome subunit alpha type-4

1

4

High-throughput

0.536

High

700718

PSA5
Proteasome subunit alpha type-5

1

4

High-throughput

0.536

High

701215

PSB5
Proteasome subunit beta type-5

1

3

High-throughput

0.536

High

887583

PSB3
Proteasome subunit beta type-3

1

4

High-throughput

0.536

High

887716

PSB2
Proteasome subunit beta type-2

1

4

High-throughput

0.536

High

954891

PSA6
Proteasome subunit alpha type-6

1

5

High-throughput

0.536

High

1136581

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

1

High-throughput

0.536

High

1389069

THA11
THAP domain-containing protein 11

1

0

High-throughput

0.518

High

403000

ANXA1
Annexin A1

1

0

High-throughput

0.513

High

424256

S10A8
Protein S100-A8

1

0

High-throughput

0.513

High

944549

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.513

High

960538

PSME3
Proteasome activator complex subunit 3

1

0

High-throughput

0.513

High

981669

RAN
GTP-binding nuclear protein Ran

1

0

High-throughput

0.513

High

1112686

CUL1
Cullin-1

1

0

High-throughput

0.513

High

1160560

SMN
Survival motor neuron protein

1

0

High-throughput

0.513

High

1201276

EAPP
E2F-associated phosphoprotein

1

0

High-throughput

0.513

High

1212843

UBR4
E3 ubiquitin-protein ligase UBR4

1

0

High-throughput

0.513

High

1280447

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.513

High

1330776

UBR7
Putative E3 ubiquitin-protein ligase UBR7

1

0

High-throughput

0.513

High

1360299

GEMI6
Gem-associated protein 6

1

0

High-throughput

0.513

High

1403164

INT14
Integrator complex subunit 14

1

0

High-throughput

0.513

High

1410234

PAGR1
PAXIP1-associated glutamate-rich protein 1

1

0

High-throughput

0.513

High

1410240

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.513

High

1410241

DDX20
Probable ATP-dependent RNA helicase DDX20

1

0

High-throughput

0.513

High

987899

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.460

High

1410245

DUS10
Dual specificity protein phosphatase 10

1

0

High-throughput

0.460

High

551587

K2C3
Keratin, type II cytoskeletal 3

1

2

High-throughput

0.407

High

618159

K2C4
Keratin, type II cytoskeletal 4

1

2

High-throughput

0.407

High

1410237

KRT84
Keratin, type II cuticular Hb4

1

2

High-throughput

0.407

High

842985

CDN2C
Cyclin-dependent kinase 4 inhibitor C

2

0

High-throughput

0.328

High

1094618

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

2

0

High-throughput

0.328

High

1292617

GPBP1
Vasculin

2

0

High-throughput

0.328

High

1386160

FWCH2
FLYWCH family member 2

2

0

High-throughput

0.328

High

391430

FRIL
Ferritin light chain

2

0

High-throughput

0.313

High

257567

TI17B
Mitochondrial import inner membrane translocase subunit Tim17-B

1

0

High-throughput

0.279

Low

776853

MYH11
Myosin-11

1

0

High-throughput

0.279

Low

1219466

SLX4I
Protein SLX4IP

1

0

High-throughput

0.279

Low

1383763

FKB10
Peptidyl-prolyl cis-trans isomerase FKBP10

1

0

High-throughput

0.279

Low

1410233

UQCC2
Ubiquinol-cytochrome c reductase complex assembly factor 2

1

0

High-throughput

0.279

Low

1410235

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

0

High-throughput

0.279

Low

1410236

FA83D
Protein FAM83D

1

0

High-throughput

0.279

Low

1410239

UQCC1
Ubiquinol-cytochrome c reductase complex assembly factor 1

1

0

High-throughput

0.279

Low

1410242

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

0

High-throughput

0.279

Low

996829

TBA1B
Tubulin alpha-1B chain

1

0

High-throughput

0.251

Low

58916

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

0

High-throughput

0.232

Low

328130

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

0

High-throughput

0.232

Low

1410238

ATG3
Ubiquitin-like-conjugating enzyme ATG3

1

0

High-throughput

0.232

Low

1410243

STRAP
Serine-threonine kinase receptor-associated protein

1

0

High-throughput

0.232

Low

1410244

ATG4B
Cysteine protease ATG4B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025