Protein: HLTF
Helicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3)

Gene: HLTF
Organism: Homo sapiens
Interactions: 138
UniProt ID: Q14527

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003723 - RNA binding
GO:0004386 - helicase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1055170

RAD18
E3 ubiquitin-protein ligase RAD18

5

5

Small-scale

0.934

High

896443

UBE2N
Ubiquitin-conjugating enzyme E2 N

4

13

Small-scale

0.912

High

1055123

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

3

15

Small-scale

0.873

High

1055148

H2B1A
Histone H2B type 1-A

3

20

High-throughput

0.861

High

1055153

CHFR
E3 ubiquitin-protein ligase CHFR

2

11

Small-scale

0.819

High

1055132

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

2

17

High-throughput

0.811

High

391696

H2A1B
Histone H2A type 1-B/E

2

18

High-throughput

0.789

High

1055149

RN166
E3 ubiquitin-protein ligase RNF166

2

5

High-throughput

0.789

High

917261

H4
Histone H4

2

13

High-throughput

0.754

High

1055115

SHPRH
E3 ubiquitin-protein ligase SHPRH

2

16

Small-scale

0.754

High

517257

PCNA
Proliferating cell nuclear antigen

8

8

Small-scale

0.746

High

651199

RFA1
Replication protein A 70 kDa DNA-binding subunit

5

9

Small-scale

0.702

High

1055163

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

1

11

High-throughput

0.698

High

470385

H2A1
Histone H2A type 1

1

18

High-throughput

0.691

High

555461

H2AX
Histone H2AX

1

20

High-throughput

0.691

High

1055124

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.691

High

1055120

PDCD1
Programmed cell death protein 1

1

0

High-throughput

0.656

High

475759

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

Small-scale

0.647

High

829001

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

10

Small-scale

0.647

High

1055113

HLTF
Helicase-like transcription factor

1

14

Small-scale

0.647

High

927752

UBE2B
Ubiquitin-conjugating enzyme E2 B

1

10

Small-scale

0.646

High

552723

RFA2
Replication protein A 32 kDa subunit

3

8

High-throughput

0.640

High

1055133

APLF
Aprataxin and PNK-like factor

3

0

High-throughput

0.638

High

227451

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.618

High

707628

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.618

High

828225

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

872267

RD23B
UV excision repair protein RAD23 homolog B

1

1

High-throughput

0.618

High

934759

H31
Histone H3.1

1

20

High-throughput

0.618

High

952334

H33
Histone H3.3

1

20

High-throughput

0.618

High

1055129

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.618

High

1055139

COP1
E3 ubiquitin-protein ligase COP1

1

16

High-throughput

0.618

High

1055160

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

18

High-throughput

0.618

High

452774

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

2

3

High-throughput

0.611

High

720461

RFA3
Replication protein A 14 kDa subunit

2

7

High-throughput

0.611

High

1055171

RN146
E3 ubiquitin-protein ligase RNF146

3

0

Small-scale

0.606

High

346781

MYC
Myc proto-oncogene protein

2

20

High-throughput

0.584

High

369603

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

435096

SP1
Transcription factor Sp1

1

13

Small-scale

0.561

High

893794

S10AA
Protein S100-A10

1

6

Small-scale

0.561

High

970916

SP3
Transcription factor Sp3

1

13

Small-scale

0.561

High

126298

ST1C2
Sulfotransferase 1C2

1

1

High-throughput

0.541

High

504080

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.541

High

841722

CDK9
Cyclin-dependent kinase 9

1

3

High-throughput

0.541

High

967170

EWS
RNA-binding protein EWS

1

6

High-throughput

0.541

High

455438

PARP1
Poly [ADP-ribose] polymerase 1

1

19

High-throughput

0.536

High

518661

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

5

High-throughput

0.536

High

535393

GFAP
Glial fibrillary acidic protein

1

2

High-throughput

0.536

High

596051

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

1

5

High-throughput

0.536

High

804243

NOTC1
Neurogenic locus notch homolog protein 1

1

5

High-throughput

0.536

High

1055114

SMC1A
Structural maintenance of chromosomes protein 1A

1

6

High-throughput

0.536

High

1055117

EMC2
ER membrane protein complex subunit 2

1

7

High-throughput

0.536

High

1055126

RA1L2
Heterogeneous nuclear ribonucleoprotein A1-like 2

1

6

High-throughput

0.536

High

1055134

SYNPO
Synaptopodin

1

9

High-throughput

0.536

High

1055145

AQP3
Aquaporin-3

1

1

High-throughput

0.536

High

1055169

TF7L2
Transcription factor 7-like 2

1

20

High-throughput

0.536

High

1055183

GPR45
Probable G-protein coupled receptor 45

1

4

High-throughput

0.536

High

269232

WBP4
WW domain-binding protein 4

1

4

High-throughput

0.527

High

1055147

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

9

High-throughput

0.515

High

1055121

PDK3
[Pyruvate dehydrogenase

1

0

High-throughput

0.513

High

1055128

SO4C1
Solute carrier organic anion transporter family member 4C1

1

0

High-throughput

0.513

High

1055141

F174A
Membrane protein FAM174A

1

0

High-throughput

0.513

High

1055142

CERK1
Ceramide kinase

1

0

High-throughput

0.513

High

1055150

APC16
Anaphase-promoting complex subunit 16

1

0

High-throughput

0.513

High

1055152

TCAL4
Transcription elongation factor A protein-like 4

1

0

High-throughput

0.513

High

1055180

DCAF1
DDB1- and CUL4-associated factor 1

1

7

Small-scale

0.501

High

1055143

HUMMR
Protein MGARP

1

1

High-throughput

0.489

High

1055181

AP4S1
AP-4 complex subunit sigma-1

1

1

High-throughput

0.489

High

146220

ARI1A
AT-rich interactive domain-containing protein 1A

1

14

Small-scale

0.479

High

148811

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.479

High

161826

ZN263
Zinc finger protein 263

1

3

Small-scale

0.479

High

209986

PRC1
Protein regulator of cytokinesis 1

1

2

High-throughput

0.479

High

244435

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.479

High

282901

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

10

High-throughput

0.479

High

300537

NFAT5
Nuclear factor of activated T-cells 5

1

13

Small-scale

0.479

High

308707

KI20A
Kinesin-like protein KIF20A

1

11

High-throughput

0.479

High

317968

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

13

High-throughput

0.479

High

359939

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

10

High-throughput

0.479

High

384838

NTRK1
High affinity nerve growth factor receptor

1

8

High-throughput

0.479

High

668355

RBMS1
RNA-binding motif, single-stranded-interacting protein 1

1

2

High-throughput

0.479

High

722107

RFC2
Replication factor C subunit 2

1

7

High-throughput

0.479

High

749496

BRCA1
Breast cancer type 1 susceptibility protein

1

11

Small-scale

0.479

High

750261

COIL
Coilin

1

4

High-throughput

0.479

High

777858

RFC5
Replication factor C subunit 5

1

7

High-throughput

0.479

High

779408

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

794255

MSH2
DNA mismatch repair protein Msh2

1

9

Small-scale

0.479

High

824003

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

20

High-throughput

0.479

High

961111

HSF1
Heat shock factor protein 1

1

3

High-throughput

0.479

High

967869

PO5F1
POU domain, class 5, transcription factor 1

1

13

High-throughput

0.479

High

1035233

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

14

High-throughput

0.479

High

1039557

SNW1
SNW domain-containing protein 1

1

7

High-throughput

0.479

High

1041573

CUL3
Cullin-3

1

15

High-throughput

0.479

High

1055118

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

8

High-throughput

0.479

High

1055119

KIF14
Kinesin-like protein KIF14

1

7

High-throughput

0.479

High

1055122

RBBP5
Retinoblastoma-binding protein 5

1

12

High-throughput

0.479

High

1055130

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

9

High-throughput

0.479

High

1055131

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

4

Small-scale

0.479

High

1055136

ZBT38
Zinc finger and BTB domain-containing protein 38

1

5

Small-scale

0.479

High

1055138

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.479

High

1055140

SNIP1
Smad nuclear-interacting protein 1

1

2

High-throughput

0.479

High

1055146

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1055151

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

9

High-throughput

0.479

High

1055155

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

1055156

CDC5L
Cell division cycle 5-like protein

1

13

High-throughput

0.479

High

1055157

RBM4
RNA-binding protein 4

1

2

Small-scale

0.479

High

1055162

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.479

High

1055164

WDR76
WD repeat-containing protein 76

1

19

High-throughput

0.479

High

1055165

NANOG
Homeobox protein NANOG

1

16

High-throughput

0.479

High

1055166

BRF2
Transcription factor IIIB 50 kDa subunit

1

6

High-throughput

0.479

High

1055167

RHOF
Rho-related GTP-binding protein RhoF

1

3

High-throughput

0.479

High

1055168

BRD7
Bromodomain-containing protein 7

1

20

High-throughput

0.479

High

1055173

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

1055174

DTL
Denticleless protein homolog

1

10

Small-scale

0.479

High

1055176

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1055177

FBW1B
F-box/WD repeat-containing protein 11

1

6

High-throughput

0.479

High

1055178

DTX4
E3 ubiquitin-protein ligase DTX4

1

7

Small-scale

0.479

High

1055179

ZN330
Zinc finger protein 330

1

6

High-throughput

0.479

High

1047439

PEBB
Core-binding factor subunit beta

1

0

High-throughput

0.458

High

1055116

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

Small-scale

0.458

High

1055127

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.458

High

1055154

RHOV
Rho-related GTP-binding protein RhoV

1

0

High-throughput

0.458

High

1055158

RPAP1
RNA polymerase II-associated protein 1

1

0

High-throughput

0.458

High

1055161

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

Small-scale

0.458

High

1055172

ETAA1
Ewing's tumor-associated antigen 1

1

0

Small-scale

0.458

High

1055175

NXF1
Nuclear RNA export factor 1

1

0

High-throughput

0.458

High

1055182

PHLA3
Pleckstrin homology-like domain family A member 3

1

0

High-throughput

0.458

High

988882

FMR1
Fragile X messenger ribonucleoprotein 1

1

7

High-throughput

0.457

High

321077

PTBP3
Polypyrimidine tract-binding protein 3

1

4

High-throughput

0.445

High

853893

NCBP2
Nuclear cap-binding protein subunit 2

1

1

High-throughput

0.445

High

1037233

TBB3
Tubulin beta-3 chain

1

1

High-throughput

0.445

High

1055135

RYBP
RING1 and YY1-binding protein

1

3

High-throughput

0.445

High

1055137

MOT11
Monocarboxylate transporter 11

1

1

High-throughput

0.445

High

1055125

CL16A
Protein CLEC16A

1

2

High-throughput

0.437

High

1055159

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

6

Small-scale

0.437

High

831326

CEBPA
CCAAT/enhancer-binding protein alpha

1

16

High-throughput

0.408

High

1014370

MPPA
Mitochondrial-processing peptidase subunit alpha

2

0

High-throughput

0.328

High

1055144

ITLN1
Intelectin-1

1

0

High-throughput

0.279

Low

279125

ATP5H
ATP synthase subunit d, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024