Protein: ZCHC8
Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8)

Gene: ZCHC8, ZCCHC8
Organism: Homo sapiens
Interactions: 132
UniProt ID: Q6NZY4

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006396 - RNA processing

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1240279

RBM7
RNA-binding protein 7

9

2

Small-scale

0.977

High

943255

RBM11
Splicing regulator RBM11

5

2

High-throughput

0.927

High

1240255

RBM4B
RNA-binding protein 4B

3

0

High-throughput

0.816

High

911619

NCBP2
Nuclear cap-binding protein subunit 2

3

0

High-throughput

0.787

High

775152

FUS
RNA-binding protein FUS

2

2

High-throughput

0.737

High

1137629

EXOS7
Exosome complex component RRP42

4

3

High-throughput

0.694

High

1240249

EXOS8
Exosome complex component RRP43

4

3

High-throughput

0.694

High

478085

SNRPA
U1 small nuclear ribonucleoprotein A

1

1

High-throughput

0.691

High

576440

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

1

High-throughput

0.691

High

729315

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

1

High-throughput

0.691

High

912928

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

1

High-throughput

0.691

High

1159970

SRSF7
Serine/arginine-rich splicing factor 7

1

2

High-throughput

0.691

High

1240267

EXOS3
Exosome complex component RRP40

4

0

High-throughput

0.670

High

717862

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

4

0

High-throughput

0.670

High

1240237

ZCH18
Zinc finger CCCH domain-containing protein 18

4

0

High-throughput

0.667

High

1240277

EXOS1
Exosome complex component CSL4

3

1

High-throughput

0.667

High

1226687

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

5

3

High-throughput

0.659

High

1160167

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.656

High

1240252

PABP5
Polyadenylate-binding protein 5

1

0

High-throughput

0.656

High

838741

MTREX
Exosome RNA helicase MTR4

4

0

Small-scale

0.651

High

1240264

EXOS4
Exosome complex component RRP41

3

4

High-throughput

0.650

High

889589

CLK2
Dual specificity protein kinase CLK2

3

0

High-throughput

0.646

High

372315

MYC
Myc proto-oncogene protein

3

1

High-throughput

0.640

High

1023807

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

4

3

High-throughput

0.636

High

1240266

EXOS5
Exosome complex component RRP46

2

4

High-throughput

0.628

High

472822

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

3

High-throughput

0.618

High

1033028

EWS
RNA-binding protein EWS

1

2

High-throughput

0.618

High

1240248

RBP56
TATA-binding protein-associated factor 2N

1

2

High-throughput

0.618

High

1240259

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

1

High-throughput

0.618

High

480190

RU1C
U1 small nuclear ribonucleoprotein C

2

0

High-throughput

0.602

High

1119059

C1D
Nuclear nucleic acid-binding protein C1D

2

0

High-throughput

0.602

High

1120205

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

Small-scale

0.586

High

1118288

EXOS2
Exosome complex component RRP4

2

0

High-throughput

0.585

High

1240254

MPH6
M-phase phosphoprotein 6

2

0

High-throughput

0.585

High

1132763

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

1

High-throughput

0.584

High

396332

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

129184

MEN1
Menin

2

0

High-throughput

0.559

High

588937

RFA2
Replication protein A 32 kDa subunit

2

0

High-throughput

0.559

High

695724

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

0

High-throughput

0.559

High

768442

RFA3
Replication protein A 14 kDa subunit

2

0

High-throughput

0.559

High

1032183

EXOSX
Exosome complex component 10

2

0

High-throughput

0.559

High

1240276

2ABG
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

2

3

High-throughput

0.558

High

991049

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

3

High-throughput

0.554

High

1240262

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.546

High

729950

1433B
14-3-3 protein beta/alpha

1

2

High-throughput

0.536

High

872439

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.536

High

1151139

OASL
2'-5'-oligoadenylate synthase-like protein

1

1

High-throughput

0.536

High

1168824

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

1

High-throughput

0.536

High

1049427

1433F
14-3-3 protein eta

2

2

High-throughput

0.521

High

765629

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.515

High

542072

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

574324

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.513

High

791463

SYUA
Alpha-synuclein

1

0

High-throughput

0.513

High

854113

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.513

High

911275

IMA5
Importin subunit alpha-5

1

0

High-throughput

0.513

High

997793

CSK21
Casein kinase II subunit alpha

1

0

High-throughput

0.513

High

1062511

DHX9
ATP-dependent RNA helicase A

1

0

High-throughput

0.513

High

1065245

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.513

High

1099703

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

1113409

CUL3
Cullin-3

1

0

High-throughput

0.513

High

1240268

DDX21
Nucleolar RNA helicase 2

1

0

High-throughput

0.513

High

799217

BRCA1
Breast cancer type 1 susceptibility protein

1

0

Small-scale

0.512

High

463986

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

1

High-throughput

0.489

High

280671

PR40A
Pre-mRNA-processing factor 40 homolog A

1

0

High-throughput

0.486

High

172950

XPO1
Exportin-1

1

1

High-throughput

0.479

High

180846

TIF1A
Transcription intermediary factor 1-alpha

1

2

High-throughput

0.479

High

242018

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

406285

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

414036

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

520136

ANDR
Androgen receptor

1

2

High-throughput

0.479

High

846348

MATR3
Matrin-3

1

1

High-throughput

0.479

High

1054472

EXOS9
Exosome complex component RRP45

1

3

High-throughput

0.479

High

1088401

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.479

High

1100017

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

1209091

EXOS6
Exosome complex component MTR3

1

5

High-throughput

0.479

High

1240240

DHX40
Probable ATP-dependent RNA helicase DHX40

1

1

High-throughput

0.479

High

1240247

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

1240251

PF21A
PHD finger protein 21A

1

3

High-throughput

0.479

High

1240253

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.479

High

1240272

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

1

High-throughput

0.479

High

190959

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

246685

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.458

High

252086

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

559991

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

621666

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

657605

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.458

High

904842

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

979840

H4
Histone H4

1

0

High-throughput

0.458

High

1040833

MECOM
Histone-lysine N-methyltransferase MECOM

1

0

High-throughput

0.458

High

1109824

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.458

High

1155466

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

1235445

IFIX
Pyrin and HIN domain-containing protein 1

1

0

High-throughput

0.458

High

1240233

GGYF2
GRB10-interacting GYF protein 2

1

0

High-throughput

0.458

High

1240234

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1240235

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1240236

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1240239

MIB1
E3 ubiquitin-protein ligase MIB1

1

0

High-throughput

0.458

High

1240245

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1240246

DI3L1
DIS3-like exonuclease 1

1

0

High-throughput

0.458

High

1240256

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

1240257

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1240258

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

1240263

RC3H2
Roquin-2

1

0

High-throughput

0.458

High

1240269

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

1240270

RNC
Ribonuclease 3

1

0

High-throughput

0.458

High

1240271

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1240273

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1240275

RCOR1
REST corepressor 1

1

0

High-throughput

0.458

High

412100

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

1226880

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.437

High

1066683

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.426

High

1240238

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.426

High

402381

GBA1
Lysosomal acid glucosylceramidase

1

0

High-throughput

0.279

Low

1240243

KCTD6
BTB/POZ domain-containing protein KCTD6

1

0

High-throughput

0.279

Low

1240250

ARRD3
Arrestin domain-containing protein 3

1

0

High-throughput

0.279

Low

1240274

SUN2
SUN domain-containing protein 2

1

0

High-throughput

0.279

Low

422344

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.261

Low

136917

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.249

Low

399984

CATA
Catalase

1

0

High-throughput

0.249

Low

548343

CP2C9
Cytochrome P450 2C9

1

0

High-throughput

0.249

Low

995648

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.249

Low

1025923

NDP
Norrin

1

0

Small-scale

0.249

Low

1240232

FBX42
F-box only protein 42

1

0

High-throughput

0.249

Low

1240244

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

1240261

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1240265

LUC7L
Putative RNA-binding protein Luc7-like 1

1

0

High-throughput

0.249

Low

1240278

HBS1L
HBS1-like protein

1

0

High-throughput

0.249

Low

322605

FBX21
F-box only protein 21

1

0

Small-scale

0.232

Low

1155065

UT2
Urea transporter 2

1

0

High-throughput

0.232

Low

1240241

S35G3
Solute carrier family 35 member G3

1

0

High-throughput

0.232

Low

1240242

S38A9
Neutral amino acid transporter 9

1

0

High-throughput

0.232

Low

1240260

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025