Protein: MBP
Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein)

Gene: MBP
Organism: Homo sapiens
Interactions: 81
UniProt ID: P02686

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0002020 - protease binding
GO:0005516 - calmodulin binding
GO:0005634 - nucleus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

388045

MK01
Mitogen-activated protein kinase 1

16

7

Small-scale

0.763

High

388088

CTDS1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

6

2

High-throughput

0.738

High

388076

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

6

1

Small-scale

0.729

High

388043

MK03
Mitogen-activated protein kinase 3

5

6

Small-scale

0.712

High

181677

CTDSL
CTD small phosphatase-like protein

4

2

High-throughput

0.698

High

388075

MK14
Mitogen-activated protein kinase 14

4

10

Small-scale

0.688

High

388053

CDK9
Cyclin-dependent kinase 9

2

8

Small-scale

0.602

High

388063

KPCZ
Protein kinase C zeta type

2

6

Small-scale

0.602

High

388038

IDE
Insulin-degrading enzyme

2

0

High-throughput

0.602

High

388032

A4
Amyloid-beta precursor protein

2

0

Small-scale

0.594

High

388087

NEUL
Neurolysin, mitochondrial

2

0

High-throughput

0.585

High

279095

ULK1
Serine/threonine-protein kinase ULK1

2

0

Small-scale

0.577

High

380240

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

1

Small-scale

0.575

High

388044

DMA
HLA class II histocompatibility antigen, DM alpha chain

1

1

Small-scale

0.575

High

388042

PTAFR
Platelet-activating factor receptor

1

2

High-throughput

0.568

High

388048

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.568

High

388059

MYPR
Myelin proteolipid protein

2

0

Small-scale

0.560

High

388039

NCK1
SH2/SH3 adapter protein NCK1

2

0

High-throughput

0.547

High

388035

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.543

High

388081

TSC1
Hamartin

1

2

High-throughput

0.541

High

388036

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.513

High

388047

NMT1
Glycylpeptide N-tetradecanoyltransferase 1

1

0

High-throughput

0.513

High

388069

SQSTM
Sequestosome-1

1

0

Small-scale

0.505

High

184549

MK13
Mitogen-activated protein kinase 13

1

10

Small-scale

0.501

High

287643

KS6A5
Ribosomal protein S6 kinase alpha-5

1

2

Small-scale

0.501

High

388030

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

Small-scale

0.501

High

388033

KPCB
Protein kinase C beta type

1

6

Small-scale

0.501

High

388034

CDK1
Cyclin-dependent kinase 1

1

1

Small-scale

0.501

High

388040

KPCA
Protein kinase C alpha type

1

6

Small-scale

0.501

High

388049

KPCI
Protein kinase C iota type

1

7

Small-scale

0.501

High

388050

MK08
Mitogen-activated protein kinase 8

1

9

Small-scale

0.501

High

388051

CDK8
Cyclin-dependent kinase 8

1

8

Small-scale

0.501

High

388052

CDK7
Cyclin-dependent kinase 7

1

2

Small-scale

0.501

High

388054

LIMK1
LIM domain kinase 1

1

2

Small-scale

0.501

High

388055

LIMK2
LIM domain kinase 2

1

1

Small-scale

0.501

High

388056

MK12
Mitogen-activated protein kinase 12

1

9

Small-scale

0.501

High

388061

CDK5
Cyclin-dependent kinase 5

1

2

Small-scale

0.501

High

388062

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

2

Small-scale

0.501

High

388064

KPCD
Protein kinase C delta type

1

6

Small-scale

0.501

High

388065

STK3
Serine/threonine-protein kinase 3

1

2

Small-scale

0.501

High

388066

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

5

Small-scale

0.501

High

388068

ILK
Scaffold protein ILK

1

1

Small-scale

0.501

High

388070

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

2

Small-scale

0.501

High

388073

MK11
Mitogen-activated protein kinase 11

1

10

Small-scale

0.501

High

388074

PKN1
Serine/threonine-protein kinase N1

1

3

Small-scale

0.501

High

388084

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

7

Small-scale

0.501

High

388085

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

3

Small-scale

0.501

High

388089

HIPK2
Homeodomain-interacting protein kinase 2

1

1

Small-scale

0.501

High

388094

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

1

1

Small-scale

0.501

High

388096

TBK1
Serine/threonine-protein kinase TBK1

1

2

Small-scale

0.501

High

388097

TLK1
Serine/threonine-protein kinase tousled-like 1

1

1

Small-scale

0.501

High

388091

DUS22
Dual specificity protein phosphatase 22

1

0

High-throughput

0.493

High

158543

CTDS2
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

1

2

High-throughput

0.489

High

388057

ATX1
Ataxin-1

1

0

High-throughput

0.486

High

388058

ATN1
Atrophin-1

1

0

High-throughput

0.486

High

388077

APTX
Aprataxin

1

0

High-throughput

0.486

High

162428

ANM5
Protein arginine N-methyltransferase 5

1

0

Small-scale

0.480

High

169881

AURKA
Aurora kinase A

1

0

Small-scale

0.480

High

362111

ABL1
Tyrosine-protein kinase ABL1

1

0

Small-scale

0.480

High

388041

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

0

Small-scale

0.480

High

388060

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

Small-scale

0.480

High

388067

2A5G
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

1

0

Small-scale

0.480

High

388071

MELK
Maternal embryonic leucine zipper kinase

1

0

Small-scale

0.480

High

388083

TRPM7
Transient receptor potential cation channel subfamily M member 7

1

0

Small-scale

0.480

High

388086

TSSK6
Testis-specific serine/threonine-protein kinase 6

1

0

Small-scale

0.480

High

388093

IRAK4
Interleukin-1 receptor-associated kinase 4

1

0

Small-scale

0.480

High

388037

MYH6
Myosin-6

1

1

High-throughput

0.479

High

345032

RIGI
Antiviral innate immune response receptor RIG-I

1

0

Small-scale

0.458

High

374325

RASH
GTPase HRas

1

0

High-throughput

0.458

High

388046

RXRB
Retinoic acid receptor RXR-beta

1

0

High-throughput

0.458

High

388080

KCNH5
Voltage-gated delayed rectifier potassium channel KCNH5

1

0

Small-scale

0.458

High

388095

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

388031

PRIO
Major prion protein

1

1

Small-scale

0.445

High

388082

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

1

0

Small-scale

0.426

High

388090

PKHF2
Pleckstrin homology domain-containing family F member 2

2

0

High-throughput

0.316

High

388072

PGFRL
Platelet-derived growth factor receptor-like protein

1

0

High-throughput

0.282

High

378276

IFN21
Interferon alpha-21

1

0

High-throughput

0.279

Low

388078

ZER1
Protein zer-1 homolog

1

0

High-throughput

0.279

Low

105078

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

388079

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

388092

FBX34
F-box only protein 34

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025