Protein: CBPD
Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180)

Gene: CBPD, CPD
Organism: Homo sapiens
Interactions: 190
UniProt ID: O75976

Gene Ontology (top 5):
GO:0004181 - metallocarboxypeptidase activity
GO:0004185 - serine-type carboxypeptidase activity
GO:0005615 - extracellular space
GO:0005886 - plasma membrane
GO:0006518 - peptide metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

299937

PRTN3
Myeloblastin

1

5

High-throughput

0.691

High

188752

TMPS2
Transmembrane protease serine 2

1

6

High-throughput

0.665

High

300007

TM11B
Transmembrane protease serine 11B

1

5

High-throughput

0.665

High

299921

LAMP1
Lysosome-associated membrane glycoprotein 1

3

2

High-throughput

0.643

High

299897

RASK
GTPase KRas

3

5

High-throughput

0.640

High

299899

TNFA
Tumor necrosis factor

3

0

High-throughput

0.638

High

299968

CXAR
Coxsackievirus and adenovirus receptor

1

3

High-throughput

0.618

High

299940

CALX
Calnexin

2

3

High-throughput

0.611

High

299946

RYK
Tyrosine-protein kinase RYK

2

9

High-throughput

0.611

High

299955

DEF1
Neutrophil defensin 1

2

0

High-throughput

0.602

High

300035

AP1M1
AP-1 complex subunit mu-1

2

0

High-throughput

0.602

High

299896

RASN
GTPase NRas

2

5

High-throughput

0.584

High

299943

EPHA2
Ephrin type-A receptor 2

2

7

High-throughput

0.584

High

299947

BASI
Basigin

2

3

High-throughput

0.584

High

299951

RAB9A
Ras-related protein Rab-9A

2

5

High-throughput

0.584

High

299965

RHOB
Rho-related GTP-binding protein RhoB

2

9

High-throughput

0.584

High

299915

LEG1
Galectin-1

2

0

High-throughput

0.576

High

299906

HEPS
Serine protease hepsin

1

5

High-throughput

0.575

High

299945

CEAM8
Cell adhesion molecule CEACAM8

1

5

High-throughput

0.575

High

300053

SCN3B
Sodium channel regulatory subunit beta-3

1

3

High-throughput

0.575

High

217630

TGON2
Trans-Golgi network integral membrane protein 2

2

0

High-throughput

0.559

High

300061

FBX2
F-box only protein 2

2

2

High-throughput

0.549

High

299900

IFN21
Interferon alpha-21

1

2

High-throughput

0.536

High

299907

INSR
Insulin receptor

1

10

High-throughput

0.536

High

299916

PGFRB
Platelet-derived growth factor receptor beta

1

5

High-throughput

0.536

High

299941

IL1R2
Interleukin-1 receptor type 2

1

1

High-throughput

0.536

High

299986

NTRK3
NT-3 growth factor receptor

1

8

High-throughput

0.536

High

300016

ARRD4
Arrestin domain-containing protein 4

1

1

High-throughput

0.536

High

300046

FBX6
F-box only protein 6

2

2

High-throughput

0.521

High

299909

CATL1
Procathepsin L

1

2

High-throughput

0.515

High

299938

CATS
Cathepsin S

1

2

High-throughput

0.515

High

299939

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.515

High

300020

CLC4D
C-type lectin domain family 4 member D

1

2

High-throughput

0.515

High

300064

CLC4E
C-type lectin domain family 4 member E

1

2

High-throughput

0.515

High

299898

GAST
Gastrin [Cleaved into: Gastrin-71

1

0

High-throughput

0.513

High

299917

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.513

High

300044

CRLF2
Cytokine receptor-like factor 2

1

0

High-throughput

0.513

High

253034

PLIN3
Perilipin-3

1

1

Small-scale

0.501

High

299911

IGF1R
Insulin-like growth factor 1 receptor

1

10

High-throughput

0.500

High

299975

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

13

High-throughput

0.500

High

299989

DDR2
Discoidin domain-containing receptor 2

1

7

High-throughput

0.500

High

299902

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.493

High

299918

FURIN
Furin

1

0

High-throughput

0.493

High

299926

AMPN
Aminopeptidase N

1

0

High-throughput

0.493

High

299971

FOXK2
Forkhead box protein K2

1

4

High-throughput

0.489

High

299980

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.489

High

299991

NHLC3
NHL repeat-containing protein 3

1

1

High-throughput

0.489

High

126408

RHOD
Rho-related GTP-binding protein RhoD

1

10

High-throughput

0.479

High

164200

NRP1
Neuropilin-1

1

2

High-throughput

0.479

High

171644

GAK
Cyclin-G-associated kinase

1

2

High-throughput

0.479

High

173801

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

1

High-throughput

0.479

High

179773

BET1
BET1 homolog

1

1

High-throughput

0.479

High

189353

STX7
Syntaxin-7

1

1

High-throughput

0.479

High

225889

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

299895

DIRA3
GTP-binding protein Di-Ras3

1

2

High-throughput

0.479

High

299903

NTRK1
High affinity nerve growth factor receptor

1

9

High-throughput

0.479

High

299908

CSF1R
Macrophage colony-stimulating factor 1 receptor

1

3

High-throughput

0.479

High

299910

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

9

High-throughput

0.479

High

299912

RHOC
Rho-related GTP-binding protein RhoC

1

8

High-throughput

0.479

High

299913

MET
Hepatocyte growth factor receptor

1

10

High-throughput

0.479

High

299922

FGFR1
Fibroblast growth factor receptor 1

1

10

High-throughput

0.479

High

299923

UBL4A
Ubiquitin-like protein 4A

1

2

High-throughput

0.479

High

299924

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.479

High

299925

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.479

High

299927

RAC2
Ras-related C3 botulinum toxin substrate 2

1

7

High-throughput

0.479

High

299929

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

299930

RAB3B
Ras-related protein Rab-3B

1

1

High-throughput

0.479

High

299931

RAB4A
Ras-related protein Rab-4A

1

2

High-throughput

0.479

High

299932

RAB5A
Ras-related protein Rab-5A

1

2

High-throughput

0.479

High

299933

ATP4A
Potassium-transporting ATPase alpha chain 1

1

1

Small-scale

0.479

High

299935

FGFR2
Fibroblast growth factor receptor 2

1

10

High-throughput

0.479

High

299942

CD1B
T-cell surface glycoprotein CD1b

1

1

High-throughput

0.479

High

299949

RAB5C
Ras-related protein Rab-5C

1

2

High-throughput

0.479

High

299950

RAB7A
Ras-related protein Rab-7a

1

5

High-throughput

0.479

High

299952

RND2
Rho-related GTP-binding protein RhoN

1

12

High-throughput

0.479

High

299953

EPHA5
Ephrin type-A receptor 5

1

8

High-throughput

0.479

High

299954

EPHA4
Ephrin type-A receptor 4

1

8

High-throughput

0.479

High

299958

RAC3
Ras-related C3 botulinum toxin substrate 3

1

7

High-throughput

0.479

High

299959

CDC42
Cell division control protein 42 homolog

1

8

High-throughput

0.479

High

299960

RAB2A
Ras-related protein Rab-2A

1

2

High-throughput

0.479

High

299961

RHOA
Transforming protein RhoA

1

9

High-throughput

0.479

High

299962

RND3
Rho-related GTP-binding protein RhoE

1

11

High-throughput

0.479

High

299966

RAC1
Ras-related C3 botulinum toxin substrate 1

1

7

High-throughput

0.479

High

299970

RHOG
Rho-related GTP-binding protein RhoG

1

7

High-throughput

0.479

High

299972

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

299976

STX4
Syntaxin-4

1

1

High-throughput

0.479

High

299979

CUL3
Cullin-3

1

2

High-throughput

0.479

High

299982

RAB35
Ras-related protein Rab-35

1

1

High-throughput

0.479

High

299984

EPHA7
Ephrin type-A receptor 7

1

6

High-throughput

0.479

High

299985

RHOH
Rho-related GTP-binding protein RhoH

1

9

High-throughput

0.479

High

299996

RNF43
E3 ubiquitin-protein ligase RNF43

1

1

High-throughput

0.479

High

299998

STYK1
Tyrosine-protein kinase STYK1

1

8

High-throughput

0.479

High

300001

SYNE3
Nesprin-3

1

1

High-throughput

0.479

High

300003

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

300004

RHOU
Rho-related GTP-binding protein RhoU

1

9

High-throughput

0.479

High

300006

ATG9A
Autophagy-related protein 9A

1

1

High-throughput

0.479

High

300013

CXD3
Gap junction delta-3 protein

1

1

High-throughput

0.479

High

300015

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.479

High

300022

DAAF4
Dynein axonemal assembly factor 4

1

3

High-throughput

0.479

High

300024

RND1
Rho-related GTP-binding protein Rho6

1

13

High-throughput

0.479

High

300028

DNJC1
DnaJ homolog subfamily C member 1

1

2

High-throughput

0.479

High

300039

DNJC5
DnaJ homolog subfamily C member 5

1

1

High-throughput

0.479

High

300043

RHOF
Rho-related GTP-binding protein RhoF

1

10

High-throughput

0.479

High

300045

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.479

High

300048

T106B
Transmembrane protein 106B

1

1

High-throughput

0.479

High

300054

SO1C1
Solute carrier organic anion transporter family member 1C1

1

1

High-throughput

0.479

High

300060

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

300065

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.479

High

299981

T132D
Transmembrane protein 132D

1

0

Small-scale

0.460

High

299994

ECM29
Proteasome adapter and scaffold protein ECM29

1

0

Small-scale

0.460

High

154453

CLD4
Claudin-4

1

0

Small-scale

0.458

High

299894

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.458

High

299904

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

299905

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

299936

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.458

High

299944

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

299948

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

299957

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

299963

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

299964

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

299967

AP2B1
AP-2 complex subunit beta

1

0

High-throughput

0.458

High

299969

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

299974

CAV1
Caveolin-1

1

0

High-throughput

0.458

High

299978

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.458

High

299987

OCLN
Occludin

1

0

High-throughput

0.458

High

299988

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

0

High-throughput

0.458

High

299997

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

300000

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

300018

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.458

High

300026

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

300030

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

0

High-throughput

0.458

High

300032

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

300033

DERL1
Derlin-1

1

0

High-throughput

0.458

High

300034

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.458

High

300036

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

300042

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

300055

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

300057

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

300058

ANFY1
Rabankyrin-5

1

0

High-throughput

0.458

High

300059

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

300067

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.458

High

299901

B3AT
Band 3 anion transport protein

1

2

High-throughput

0.445

High

299914

P3
P3 protein

1

2

High-throughput

0.445

High

299956

CD81
CD81 antigen

1

1

High-throughput

0.445

High

299990

MICB
MHC class I polypeptide-related sequence B

1

1

High-throughput

0.445

High

299992

NTCP5
Sodium/bile acid cotransporter 5

1

2

High-throughput

0.445

High

299999

BRID5
BRICHOS domain-containing protein 5

1

1

High-throughput

0.445

High

300029

MF14A
Hippocampus abundant transcript 1 protein

1

1

High-throughput

0.445

High

104981

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

299973

KIF23
Kinesin-like protein KIF23

1

3

High-throughput

0.437

High

299977

SMAD4
Mothers against decapentaplegic homolog 4

1

1

High-throughput

0.437

High

299995

FHI2A
FHF complex subunit HOOK interacting protein 2A

1

1

High-throughput

0.437

High

300008

FHI2B
FHF complex subunit HOOK-interacting protein 2B

1

1

High-throughput

0.437

High

300009

HOOK3
Protein Hook homolog 3

1

4

High-throughput

0.437

High

300025

GOGA1
Golgin subfamily A member 1

1

3

High-throughput

0.437

High

300037

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.437

High

300040

MTG2
Mitochondrial ribosome-associated GTPase 2

1

2

High-throughput

0.437

High

299920

ACHB
Acetylcholine receptor subunit beta

1

0

High-throughput

0.426

High

299934

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.426

High

300005

NIPA1
Magnesium transporter NIPA1

1

0

High-throughput

0.426

High

300012

AGRG5
Adhesion G-protein coupled receptor G5

1

0

High-throughput

0.426

High

300023

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.426

High

300051

S39A1
Zinc transporter ZIP1

1

0

High-throughput

0.426

High

300062

DKKL1
Dickkopf-like protein 1

1

0

High-throughput

0.426

High

300047

DISC1
Disrupted in schizophrenia 1 protein

1

2

High-throughput

0.417

High

170588

CLGN
Calmegin

1

3

High-throughput

0.407

High

253422

CST8
Cystatin-8

1

1

High-throughput

0.407

High

300019

PATE1
Prostate and testis expressed protein 1

1

1

High-throughput

0.407

High

300066

PRG3
Proteoglycan 3

1

1

High-throughput

0.407

High

300049

UFSP2
Ufm1-specific protease 2

2

0

High-throughput

0.328

High

300052

AATF
Protein AATF

1

0

High-throughput

0.282

High

300011

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

300041

SG196
Protein O-mannose kinase

1

0

High-throughput

0.279

Low

139785

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

299893

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.249

Low

299919

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.249

Low

299928

TFE2
Transcription factor E2-alpha

1

0

High-throughput

0.249

Low

299983

KS6A2
Ribosomal protein S6 kinase alpha-2

1

0

High-throughput

0.249

Low

299993

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.249

Low

300010

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

300014

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.249

Low

300021

ASB17
Ankyrin repeat and SOCS box protein 17

1

0

High-throughput

0.249

Low

300031

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.249

Low

300038

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.249

Low

300050

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

300056

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

300063

PPM1H
Protein phosphatase 1H

1

0

High-throughput

0.249

Low

300002

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low

300017

ZNT7
Zinc transporter 7

1

0

High-throughput

0.232

Low

300027

AURKB
Aurora kinase B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025