Protein: CCHL
Holocytochrome c-type synthase (EC 4.4.1.17) (Cytochrome c-type heme lyase)

Gene: CCHL, HCCS
Organism: Homo sapiens
Interactions: 109
UniProt ID: P53701

Gene Ontology (top 5):
GO:0004408 - holocytochrome-c synthase activity
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005829 - cytosol
GO:0009887 - animal organ morphogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

922769

PHF23
PHD finger protein 23

4

0

High-throughput

0.670

High

922795

FZR1
Fizzy-related protein homolog

4

0

High-throughput

0.664

High

253066

PLIN3
Perilipin-3

3

0

High-throughput

0.638

High

471634

CY1
Cytochrome c1, heme protein, mitochondrial

3

0

High-throughput

0.638

High

922754

TADA1
Transcriptional adapter 1

3

0

High-throughput

0.638

High

922755

F136A
Protein FAM136A

3

0

High-throughput

0.638

High

922757

RRFM
Ribosome-recycling factor, mitochondrial

3

0

High-throughput

0.638

High

922779

MARH7
E3 ubiquitin-protein ligase MARCHF7

3

0

High-throughput

0.638

High

922791

ARMX3
Armadillo repeat-containing X-linked protein 3

3

0

High-throughput

0.638

High

922731

AGK
Acylglycerol kinase, mitochondrial

2

0

High-throughput

0.602

High

922745

ASCC3
Activating signal cointegrator 1 complex subunit 3

2

0

High-throughput

0.595

High

922723

CYC
Cytochrome c

2

0

High-throughput

0.585

High

922784

M1IP1
Mid1-interacting protein 1

2

0

High-throughput

0.585

High

348434

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

1

High-throughput

0.584

High

922725

SNX1
Sorting nexin-1

2

0

High-throughput

0.580

High

922783

SENP2
Sentrin-specific protease 2

2

0

High-throughput

0.580

High

922792

CIDEB
Lipid transferase CIDEB

2

0

High-throughput

0.580

High

378233

IFNA1
Interferon alpha-1/13

2

1

High-throughput

0.574

High

378284

IFN21
Interferon alpha-21

2

1

High-throughput

0.574

High

922739

SNX20
Sorting nexin-20

2

1

High-throughput

0.574

High

559914

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

2

0

High-throughput

0.559

High

922780

SFXN1
Sideroflexin-1

2

0

High-throughput

0.559

High

922796

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

1

High-throughput

0.536

High

230949

TYOBP
TYRO protein tyrosine kinase-binding protein

1

0

High-throughput

0.513

High

483837

CD7
T-cell antigen CD7

1

0

High-throughput

0.513

High

922720

RRAS2
Ras-related protein R-Ras2

1

0

High-throughput

0.513

High

922736

CRTC3
CREB-regulated transcription coactivator 3

1

0

High-throughput

0.513

High

922737

CERS6
Ceramide synthase 6

1

0

High-throughput

0.513

High

922750

HUMMR
Protein MGARP

1

0

High-throughput

0.513

High

922768

CHCH5
Coiled-coil-helix-coiled-coil-helix domain-containing protein 5

1

0

High-throughput

0.513

High

922777

PGES2
Prostaglandin E synthase 2

1

0

High-throughput

0.513

High

922785

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

0

High-throughput

0.513

High

922787

RM17
Large ribosomal subunit protein bL17m

1

0

High-throughput

0.513

High

922789

EVA1B
Protein eva-1 homolog B

1

0

High-throughput

0.513

High

922746

CLRN3
Clarin-3

1

0

High-throughput

0.493

High

922798

SHLB1
Endophilin-B1

1

0

High-throughput

0.493

High

922718

RAB2A
Ras-related protein Rab-2A

1

1

High-throughput

0.479

High

922719

RAB14
Ras-related protein Rab-14

1

1

High-throughput

0.479

High

922773

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

1

High-throughput

0.479

High

922788

ARL8B
ADP-ribosylation factor-like protein 8B

1

2

High-throughput

0.479

High

922794

RAB21
Ras-related protein Rab-21

1

1

High-throughput

0.479

High

922801

MTCH2
Mitochondrial carrier homolog 2

1

1

High-throughput

0.479

High

125347

LEG9
Galectin-9

1

0

High-throughput

0.458

High

137685

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

274997

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

292102

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

0

High-throughput

0.458

High

296216

SCO1
Protein SCO1 homolog, mitochondrial

1

0

High-throughput

0.458

High

402348

GBA1
Lysosomal acid glucosylceramidase

1

0

High-throughput

0.458

High

642212

COMT
Catechol O-methyltransferase

1

0

High-throughput

0.458

High

646795

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.458

High

922722

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

922728

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

922734

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

922741

TAXB1
Tax1-binding protein 1

1

0

High-throughput

0.458

High

922748

ATLA2
Atlastin-2

1

0

High-throughput

0.458

High

922751

DCAKD
Dephospho-CoA kinase domain-containing protein

1

0

High-throughput

0.458

High

922752

ASB11
Ankyrin repeat and SOCS box protein 11

1

0

High-throughput

0.458

High

922756

OPTN
Optineurin

1

0

High-throughput

0.458

High

922758

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.458

High

922759

RMD5B
E3 ubiquitin-protein transferase RMND5B

1

0

High-throughput

0.458

High

922760

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

922761

IMP1L
Mitochondrial inner membrane protease subunit 1

1

0

High-throughput

0.458

High

922764

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

0

High-throughput

0.458

High

922765

PHB2
Prohibitin-2

1

0

High-throughput

0.458

High

922766

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

0

High-throughput

0.458

High

922767

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.458

High

922770

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

922771

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

0

High-throughput

0.458

High

922772

SHRPN
Sharpin

1

0

Small-scale

0.458

High

922774

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

922781

ZFYV1
Zinc finger FYVE domain-containing protein 1

1

0

Small-scale

0.458

High

922782

PLRKT
Plasminogen receptor

1

0

High-throughput

0.458

High

922753

S39A7
Zinc transporter SLC39A7

1

1

High-throughput

0.445

High

922738

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

922747

MROH1
Maestro heat-like repeat-containing protein family member 1

1

1

High-throughput

0.437

High

653214

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

841119

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.426

High

922742

TRXR3
Thioredoxin reductase 3

1

0

High-throughput

0.426

High

922762

MF14A
Hippocampus abundant transcript 1 protein

1

0

High-throughput

0.426

High

96953

E9PHY8
Maestro heat like repeat family member 1

1

1

High-throughput

0.407

High

922730

S39AC
Zinc transporter ZIP12

1

1

High-throughput

0.407

High

333451

MPZL1
Myelin protein zero-like protein 1

3

0

High-throughput

0.347

High

922727

NPAT
Protein NPAT

3

0

High-throughput

0.347

High

922743

MET16
RNA N(6)-adenosine-methyltransferase METTL16

3

0

High-throughput

0.347

High

922786

KCNQ5
Potassium voltage-gated channel subfamily KQT member 5

3

0

High-throughput

0.347

High

553740

MYCL
Protein L-Myc

2

0

High-throughput

0.328

High

720600

GRPR
Gastrin-releasing peptide receptor

2

0

High-throughput

0.328

High

922778

PACC1
Proton-activated chloride channel

2

0

High-throughput

0.328

High

922793

GPTC8
G patch domain-containing protein 8

2

0

High-throughput

0.318

High

922732

CA220
Putative uncharacterized protein C1orf220

2

0

High-throughput

0.288

High

376600

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

0

High-throughput

0.279

Low

922724

TNR9
Tumor necrosis factor receptor superfamily member 9

1

0

High-throughput

0.279

Low

922733

HES3
Transcription factor HES-3

1

0

High-throughput

0.279

Low

922740

GGN
Gametogenetin

1

0

High-throughput

0.279

Low

922763

FCRL4
Fc receptor-like protein 4

1

0

High-throughput

0.279

Low

922800

WIF1
Wnt inhibitory factor 1

1

0

High-throughput

0.279

Low

441530

CCKN
Cholecystokinin

1

0

High-throughput

0.268

Low

606489

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.249

Low

922726

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.249

Low

922729

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

0

High-throughput

0.249

Low

922749

RDH11
Retinol dehydrogenase 11

1

0

High-throughput

0.249

Low

922775

TMX1
Thioredoxin-related transmembrane protein 1

1

0

High-throughput

0.249

Low

922776

SG196
Protein O-mannose kinase

1

0

High-throughput

0.249

Low

922790

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

922797

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

922799

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

922721

S35A2
UDP-galactose translocator

1

0

High-throughput

0.232

Low

922735

GTR7
Solute carrier family 2, facilitated glucose transporter member 7

1

0

High-throughput

0.232

Low

922744

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025