Protein: SHPRH
E3 ubiquitin-protein ligase SHPRH (EC 2.3.2.27) (EC 3.6.4.-) (RING-type E3 ubiquitin transferase SHPRH) (SNF2, histone-linker, PHD and RING finger domain-containing helicase)

Gene: SHPRH
Organism: Homo sapiens
Interactions: 93
UniProt ID: Q149N8

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0000786 - nucleosome
GO:0003677 - DNA binding
GO:0004386 - helicase activity
GO:0004842 - ubiquitin-protein transferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1066311

RBBP4
Histone-binding protein RBBP4

5

20

High-throughput

0.925

High

998328

H31
Histone H3.1

5

20

Small-scale

0.922

High

1135249

RBBP7
Histone-binding protein RBBP7

4

20

High-throughput

0.892

High

979675

H4
Histone H4

3

19

Small-scale

0.853

High

957739

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

10

Small-scale

0.757

High

1127712

HLTF
Helicase-like transcription factor

2

16

Small-scale

0.754

High

1135279

DTL
Denticleless protein homolog

2

20

Small-scale

0.754

High

1135247

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

11

Small-scale

0.734

High

1135265

FBXW7
F-box/WD repeat-containing protein 7

1

13

High-throughput

0.698

High

1135250

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.691

High

1135278

RAD18
E3 ubiquitin-protein ligase RAD18

3

7

Small-scale

0.674

High

906668

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

11

Small-scale

0.647

High

1135244

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

16

Small-scale

0.647

High

551051

PCNA
Proliferating cell nuclear antigen

3

7

Small-scale

0.646

High

990966

UBE2B
Ubiquitin-conjugating enzyme E2 B

1

8

Small-scale

0.646

High

285288

EED
Polycomb protein EED

1

20

High-throughput

0.618

High

339979

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

8

Small-scale

0.618

High

418994

H2A1B
Histone H2A type 1-B/E

1

20

High-throughput

0.618

High

703318

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

19

High-throughput

0.618

High

883543

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

884337

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

8

Small-scale

0.618

High

1016869

H33
Histone H3.3

1

20

High-throughput

0.618

High

1088351

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

17

High-throughput

0.618

High

1132698

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

17

High-throughput

0.618

High

1135258

CHD5
Chromodomain-helicase-DNA-binding protein 5

1

16

High-throughput

0.618

High

801322

HSPA9
Stress-70 protein, mitochondrial

2

18

High-throughput

0.601

High

487330

PARP1
Poly [ADP-ribose] polymerase 1

1

20

High-throughput

0.536

High

682486

S100P
Protein S100-P

1

16

High-throughput

0.536

High

1135246

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.536

High

1135254

UBP49
Ubiquitin carboxyl-terminal hydrolase 49

1

10

High-throughput

0.536

High

1135281

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

7

High-throughput

0.536

High

656127

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

5

High-throughput

0.515

High

789896

FDFT
Squalene synthase

1

1

High-throughput

0.494

High

706126

S10A2
Protein S100-A2

1

16

High-throughput

0.489

High

848628

MAGA9
Melanoma-associated antigen 9

1

11

High-throughput

0.489

High

155306

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

10

High-throughput

0.479

High

168248

HAT1
Histone acetyltransferase type B catalytic subunit

1

4

High-throughput

0.479

High

210280

PHF1
PHD finger protein 1

1

13

High-throughput

0.479

High

274330

SIN3B
Paired amphipathic helix protein Sin3b

1

19

High-throughput

0.479

High

282255

SAP30
Histone deacetylase complex subunit SAP30

1

6

High-throughput

0.479

High

316858

MTA2
Metastasis-associated protein MTA2

1

20

High-throughput

0.479

High

317178

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

10

Small-scale

0.479

High

321976

NFAT5
Nuclear factor of activated T-cells 5

1

20

Small-scale

0.479

High

352145

MBD3
Methyl-CpG-binding domain protein 3

1

20

High-throughput

0.479

High

519507

MYBB
Myb-related protein B

1

20

High-throughput

0.479

High

604664

UBF1
Nucleolar transcription factor 1

1

20

Small-scale

0.479

High

714130

PML
Protein PML

1

19

High-throughput

0.479

High

827407

MLH1
DNA mismatch repair protein Mlh1

1

2

Small-scale

0.479

High

982440

RS15
Small ribosomal subunit protein uS19

1

4

High-throughput

0.479

High

982953

RS25
Small ribosomal subunit protein eS25

1

4

High-throughput

0.479

High

983807

RBX1
E3 ubiquitin-protein ligase RBX1

1

2

High-throughput

0.479

High

1045301

TF65
Transcription factor p65

1

20

High-throughput

0.479

High

1086765

BPTF
Nucleosome-remodeling factor subunit BPTF

1

20

High-throughput

0.479

High

1102540

MTA1
Metastasis-associated protein MTA1

1

20

High-throughput

0.479

High

1105925

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

10

High-throughput

0.479

High

1113132

CUL3
Cullin-3

1

16

High-throughput

0.479

High

1135245

SUZ12
Polycomb protein SUZ12

1

9

High-throughput

0.479

High

1135248

EZH2
Histone-lysine N-methyltransferase EZH2

1

20

High-throughput

0.479

High

1135251

ARI4B
AT-rich interactive domain-containing protein 4B

1

20

High-throughput

0.479

High

1135253

LIN9
Protein lin-9 homolog

1

5

High-throughput

0.479

High

1135255

P66A
Transcriptional repressor p66-alpha

1

15

High-throughput

0.479

High

1135256

BAP18
BPTF-associated chromatin complex component 1

1

5

High-throughput

0.479

High

1135257

FBX22
F-box only protein 22

1

4

High-throughput

0.479

High

1135259

GATD1
GATA zinc finger domain-containing protein 1

1

2

High-throughput

0.479

High

1135261

P66B
Transcriptional repressor p66-beta

1

15

High-throughput

0.479

High

1135263

KAT6A
Histone acetyltransferase KAT6A

1

17

High-throughput

0.479

High

1135267

LIN37
Protein lin-37 homolog

1

5

High-throughput

0.479

High

1135269

Z512B
Zinc finger protein 512B

1

16

High-throughput

0.479

High

1135272

SIN3A
Paired amphipathic helix protein Sin3a

1

19

High-throughput

0.479

High

1135273

MTA3
Metastasis-associated protein MTA3

1

20

High-throughput

0.479

High

1135274

BC11B
B-cell lymphoma/leukemia 11B

1

13

High-throughput

0.479

High

1135276

BC11A
BCL11 transcription factor A

1

13

High-throughput

0.479

High

1135277

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

11

High-throughput

0.479

High

1135282

ZN219
Zinc finger protein 219

1

3

High-throughput

0.479

High

1135283

MBD2
Methyl-CpG-binding domain protein 2

1

20

High-throughput

0.479

High

1135284

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

1135285

HMGX4
HMG domain-containing protein 4

1

20

High-throughput

0.479

High

1135286

ZN330
Zinc finger protein 330

1

7

High-throughput

0.479

High

1135287

MTF2
Metal-response element-binding transcription factor 2

1

14

High-throughput

0.479

High

1135288

TRRAP
Transformation/transcription domain-associated protein

1

13

High-throughput

0.479

High

828775

MDHM
Malate dehydrogenase, mitochondrial

1

3

High-throughput

0.437

High

1133416

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.437

High

1135252

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

11

High-throughput

0.437

High

1135262

BBX
HMG box transcription factor BBX

1

20

High-throughput

0.437

High

1135268

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.437

High

1135271

PWP2A
PWWP domain-containing protein 2A

1

14

High-throughput

0.437

High

1135275

SP130
Histone deacetylase complex subunit SAP130

1

15

High-throughput

0.437

High

1135280

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

6

High-throughput

0.407

High

1135260

EDAD
Ectodysplasin-A receptor-associated adapter protein

1

0

High-throughput

0.299

High

1135266

BORC6
BLOC-1-related complex subunit 6

1

0

High-throughput

0.299

High

1135264

LPP
Lipoma-preferred partner

1

0

High-throughput

0.238

Low

1135270

AP4AT
AP-4 complex accessory subunit Tepsin

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025