Protein: NSUN4
5-cytosine rRNA methyltransferase NSUN4 (EC 2.1.1.-) (5-cytosine tRNA methyltransferase NSUN4) (EC 2.1.1.-) (NOL1/NOP2/Sun domain family member 4) (mRNA cytosine C(5)-methyltransferase NSUN4) (EC 2.1.1.-)

Gene: NSUN4
Organism: Homo sapiens
Interactions: 88
UniProt ID: Q96CB9

Gene Ontology (top 5):
GO:0000957 - mitochondrial RNA catabolic process
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0005762 - mitochondrial large ribosomal subunit
GO:0008168 - methyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

532843

CH60
60 kDa heat shock protein, mitochondrial

4

2

High-throughput

0.691

High

1358821

KBTB7
Kelch repeat and BTB domain-containing protein 7

6

2

Small-scale

0.670

High

1280243

MTEF4
Transcription termination factor 4, mitochondrial

2

2

Small-scale

0.651

High

1385770

NSUN4
5-cytosine rRNA methyltransferase NSUN4

1

5

Small-scale

0.647

High

1328437

S2541
Mitochondrial carrier protein SCaMC-3L

3

0

High-throughput

0.638

High

686327

RL13
Large ribosomal subunit protein eL13

3

2

High-throughput

0.609

High

349697

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

2

0

High-throughput

0.602

High

1385779

AKIP
Small ribosomal subunit protein mS38

2

0

High-throughput

0.602

High

1108020

SQSTM
Sequestosome-1

2

0

Small-scale

0.585

High

935436

FGF8
Fibroblast growth factor 8

2

2

High-throughput

0.574

High

984488

RL30
Large ribosomal subunit protein eL30

2

1

High-throughput

0.574

High

1057843

RL18
Large ribosomal subunit protein eL18

2

2

High-throughput

0.574

High

1230888

Z324B
Zinc finger protein 324B

2

9

High-throughput

0.574

High

1385775

MND1
Meiotic nuclear division protein 1 homolog

2

1

High-throughput

0.574

High

1278785

HDGR2
Hepatoma-derived growth factor-related protein 2

2

2

High-throughput

0.549

High

1385776

REXO4
RNA exonuclease 4

2

1

High-throughput

0.549

High

208333

RRP8
Ribosomal RNA-processing protein 8

1

1

High-throughput

0.536

High

275338

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

1

High-throughput

0.536

High

690528

KAD4
Adenylate kinase 4, mitochondrial

1

1

High-throughput

0.536

High

869207

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

1

High-throughput

0.536

High

1049651

1433F
14-3-3 protein eta

1

3

High-throughput

0.536

High

1123368

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.536

High

1238404

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

1

1

High-throughput

0.536

High

1242605

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

1

High-throughput

0.536

High

1314196

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

5

High-throughput

0.536

High

1385772

RT24
Small ribosomal subunit protein uS3m

1

1

High-throughput

0.536

High

1385785

AMACR
Alpha-methylacyl-CoA racemase

1

1

High-throughput

0.536

High

1385787

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

1385788

RT02
Small ribosomal subunit protein uS2m

1

4

High-throughput

0.536

High

396676

ESR1
Estrogen receptor

2

6

High-throughput

0.521

High

289799

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.513

High

1160431

TAZ
Tafazzin

1

0

High-throughput

0.513

High

1385782

DIC
Mitochondrial dicarboxylate carrier

1

0

High-throughput

0.513

High

1385783

NPS3A
Protein NipSnap homolog 3A

1

0

High-throughput

0.513

High

848919

MAGAB
Melanoma-associated antigen 11

1

8

High-throughput

0.494

High

191739

MAGB2
Melanoma-associated antigen B2

1

8

High-throughput

0.489

High

287082

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

6

High-throughput

0.489

High

288728

NPM3
Nucleoplasmin-3

1

3

High-throughput

0.489

High

290668

SURF6
Surfeit locus protein 6

1

1

High-throughput

0.489

High

428900

RLA0
Large ribosomal subunit protein uL10

1

5

High-throughput

0.489

High

521849

H14
Histone H1.4

1

6

High-throughput

0.489

High

596286

H12
Histone H1.2

1

6

High-throughput

0.489

High

848694

MAGA9
Melanoma-associated antigen 9

1

8

High-throughput

0.489

High

859939

RL28
Large ribosomal subunit protein eL28

1

1

High-throughput

0.489

High

888952

TMEDA
Transmembrane emp24 domain-containing protein 10

1

1

High-throughput

0.489

High

945720

FOXL2
Forkhead box protein L2

1

3

High-throughput

0.489

High

960830

RL15
Large ribosomal subunit protein eL15

1

2

High-throughput

0.489

High

1062070

SRSF4
Serine/arginine-rich splicing factor 4

1

5

High-throughput

0.489

High

1099195

SRSF5
Serine/arginine-rich splicing factor 5

1

5

High-throughput

0.489

High

1384937

TRI43
Tripartite motif-containing protein 43

1

1

High-throughput

0.489

High

1385774

MBB1A
Myb-binding protein 1A

1

1

High-throughput

0.489

High

1385781

MYEF2
Myelin expression factor 2

1

1

High-throughput

0.489

High

1385789

RL36
Large ribosomal subunit protein eL36

1

3

High-throughput

0.489

High

1366984

ESR2
Estrogen receptor beta

1

5

High-throughput

0.479

High

508409

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.457

High

653491

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.445

High

188703

BIRC5
Baculoviral IAP repeat-containing protein 5

1

1

Small-scale

0.437

High

905009

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.437

High

913793

ZN131
Zinc finger protein 131

1

9

High-throughput

0.437

High

937843

FOXA1
Hepatocyte nuclear factor 3-alpha

1

3

High-throughput

0.437

High

1197665

MIDN
Midnolin

1

3

High-throughput

0.437

High

1254985

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

1276617

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.437

High

1368350

REQU
Zinc finger protein ubi-d4

1

3

High-throughput

0.437

High

1385784

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.437

High

1385786

HECD1
E3 ubiquitin-protein ligase HECTD1

1

7

High-throughput

0.437

High

1385790

ARI1
E3 ubiquitin-protein ligase ARIH1

1

7

High-throughput

0.437

High

1349465

F110B
Protein FAM110B

1

0

High-throughput

0.426

High

951802

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

High-throughput

0.407

High

1227221

A16L1
Autophagy-related protein 16-1

1

8

High-throughput

0.407

High

1385778

CAH10
Carbonic anhydrase-related protein 10

4

0

High-throughput

0.360

High

902969

INSL3
Insulin-like 3

3

0

High-throughput

0.347

High

1359297

SSMM1
Serine-rich single-pass membrane protein 1

3

0

High-throughput

0.345

High

220706

DENR
Density-regulated protein

2

0

High-throughput

0.328

High

1256711

NKAP1
Uncharacterized protein NKAPD1

2

0

High-throughput

0.328

High

1033126

EWS
RNA-binding protein EWS

1

0

High-throughput

0.282

High

585816

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

0

High-throughput

0.279

Low

788739

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.279

Low

1260390

H1FNT
Testis-specific H1 histone

1

0

High-throughput

0.279

Low

1385773

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.279

Low

1385777

CHST7
Carbohydrate sulfotransferase 7

1

0

High-throughput

0.279

Low

1385780

LYAR
Cell growth-regulating nucleolar protein

1

0

High-throughput

0.279

Low

333135

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

0

Small-scale

0.249

Low

1252922

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.249

Low

1314526

TM192
Transmembrane protein 192

1

0

High-throughput

0.249

Low

1380619

FBX32
F-box only protein 32

1

0

High-throughput

0.249

Low

1385771

SPDLY
Protein Spindly

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025