Protein: MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1 (EC 2.8.1.14) (MTO2 homolog)

Gene: MTU1, TRMU
Organism: Homo sapiens
Interactions: 92
UniProt ID: O75648

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0002143 - tRNA wobble position uridine thiolation
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0061708 - tRNA-5-taurinomethyluridine 2-sulfurtransferase

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

289750

CH60
60 kDa heat shock protein, mitochondrial

2

1

High-throughput

0.628

High

289768

YBEY
Endoribonuclease YbeY

2

0

High-throughput

0.602

High

289811

THUM3
tRNA

2

0

High-throughput

0.602

High

240299

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

289751

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.536

High

289756

CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial

1

1

High-throughput

0.536

High

289758

HS71L
Heat shock 70 kDa protein 1-like

1

2

High-throughput

0.536

High

289767

HSP72
Heat shock-related 70 kDa protein 2

1

2

High-throughput

0.536

High

289805

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

1

High-throughput

0.536

High

289815

CLPB
Mitochondrial disaggregase

1

1

High-throughput

0.536

High

124169

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.513

High

166594

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

0

High-throughput

0.513

High

289753

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

0

High-throughput

0.513

High

289760

LONM
Lon protease homolog, mitochondrial

1

0

High-throughput

0.513

High

289762

CACP
Carnitine O-acetyltransferase

1

0

High-throughput

0.513

High

289764

PPOX
Protoporphyrinogen oxidase

1

0

High-throughput

0.513

High

289765

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.513

High

289766

DPOG1
DNA polymerase subunit gamma-1

1

0

High-throughput

0.513

High

289771

TRI32
E3 ubiquitin-protein ligase TRIM32

1

0

High-throughput

0.513

High

289772

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

0

High-throughput

0.513

High

289773

PEX6
Peroxisomal ATPase PEX6

1

0

High-throughput

0.513

High

289774

SYLM
Leucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

289783

ACD10
Acyl-CoA dehydrogenase family member 10

1

0

High-throughput

0.513

High

289784

TATD1
Deoxyribonuclease TATDN1

1

0

High-throughput

0.513

High

289785

SYDM
Aspartate--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

289787

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.513

High

289792

FCSK
L-fucose kinase

1

0

High-throughput

0.513

High

289794

P4K2B
Phosphatidylinositol 4-kinase type 2-beta

1

0

High-throughput

0.513

High

289799

NSUN4
5-cytosine rRNA methyltransferase NSUN4

1

0

High-throughput

0.513

High

289800

ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial

1

0

High-throughput

0.513

High

289802

SYNM
Asparaginyl-tRNA synthetase

1

0

High-throughput

0.513

High

289804

PASK
PAS domain-containing serine/threonine-protein kinase

1

0

High-throughput

0.513

High

289806

IF140
Intraflagellar transport protein 140 homolog

1

0

High-throughput

0.513

High

289812

SYTM
Threonine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

289819

RSAD1
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial

1

0

High-throughput

0.513

High

289821

TMLH
Trimethyllysine dioxygenase, mitochondrial

1

0

High-throughput

0.513

High

289822

PAPD1
Poly(A) RNA polymerase, mitochondrial

1

0

High-throughput

0.513

High

289826

SARDH
Sarcosine dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

289827

RUVB1
RuvB-like 1

1

0

High-throughput

0.513

High

289828

COQ4
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial

1

0

High-throughput

0.513

High

289789

TBA1A
Tubulin alpha-1A chain

1

2

High-throughput

0.489

High

289808

TBA1C
Tubulin alpha-1C chain

1

2

High-throughput

0.489

High

289746

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

289754

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

289761

HELZ
Probable helicase with zinc finger domain

1

0

High-throughput

0.426

High

289801

LRC46
Leucine-rich repeat-containing protein 46

1

1

High-throughput

0.407

High

289781

F219B
Protein FAM219B

3

0

High-throughput

0.347

High

289755

IL1R2
Interleukin-1 receptor type 2

2

0

High-throughput

0.328

High

289824

HXC10
Homeobox protein Hox-C10

2

0

High-throughput

0.328

High

48126

IFT56
Intraflagellar transport protein 56

1

0

High-throughput

0.279

Low

245655

GANP
Germinal-center associated nuclear protein

1

0

High-throughput

0.279

Low

289747

TBB5
Tubulin beta chain

1

0

High-throughput

0.279

Low

289749

RAP2A
Ras-related protein Rap-2a

1

0

High-throughput

0.279

Low

289752

MBL2
Mannose-binding protein C

1

0

High-throughput

0.279

Low

289757

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.279

Low

289763

VPS41
Vacuolar protein sorting-associated protein 41 homolog

1

0

High-throughput

0.279

Low

289769

PRAME
Melanoma antigen preferentially expressed in tumors

1

0

High-throughput

0.279

Low

289775

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

0

High-throughput

0.279

Low

289776

CART

1

0

High-throughput

0.279

Low

289777

QRIC1
Transcriptional regulator QRICH1

1

0

High-throughput

0.279

Low

289778

PSMG4
Proteasome assembly chaperone 4

1

0

High-throughput

0.279

Low

289779

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

1

0

High-throughput

0.279

Low

289780

OBI1
ORC ubiquitin ligase 1

1

0

High-throughput

0.279

Low

289782

ANR40
Ankyrin repeat domain-containing protein 40

1

0

High-throughput

0.279

Low

289786

WDR59
GATOR2 complex protein WDR59

1

0

High-throughput

0.279

Low

289790

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

0

High-throughput

0.279

Low

289791

CEP97
Centrosomal protein of 97 kDa

1

0

High-throughput

0.279

Low

289793

WDTC1
WD and tetratricopeptide repeats protein 1

1

0

High-throughput

0.279

Low

289795

FAT3
Protocadherin Fat 3

1

0

High-throughput

0.279

Low

289796

STYX
Serine/threonine/tyrosine-interacting protein

1

0

High-throughput

0.279

Low

289797

HPS3
BLOC-2 complex member HPS3

1

0

High-throughput

0.279

Low

289798

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.279

Low

289809

PSMG3
Proteasome assembly chaperone 3

1

0

High-throughput

0.279

Low

289813

TNG6
Transport and Golgi organization protein 6 homolog

1

0

High-throughput

0.279

Low

289814

PIP30
PSME3-interacting protein

1

0

High-throughput

0.279

Low

289816

SMOC1
SPARC-related modular calcium-binding protein 1

1

0

High-throughput

0.279

Low

289818

ESRP2
Epithelial splicing regulatory protein 2

1

0

High-throughput

0.279

Low

289820

TF7L2
Transcription factor 7-like 2

1

0

High-throughput

0.279

Low

289823

RNF12
E3 ubiquitin-protein ligase RLIM

1

0

High-throughput

0.279

Low

289825

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

0

High-throughput

0.279

Low

289829

GPSM3
G-protein-signaling modulator 3

1

0

High-throughput

0.279

Low

289830

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

1

0

High-throughput

0.279

Low

183315

ZN185
Zinc finger protein 185

1

0

High-throughput

0.269

Low

289748

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.261

Low

289759

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

289788

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

289817

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

289745

FRIL
Ferritin light chain

1

0

High-throughput

0.232

Low

289770

EF1A2
Elongation factor 1-alpha 2

1

0

High-throughput

0.232

Low

289803

MF14A
Hippocampus abundant transcript 1 protein

1

0

High-throughput

0.232

Low

289807

CCNL2
Cyclin-L2

1

0

High-throughput

0.232

Low

289810

MTA3
Metastasis-associated protein MTA3

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025