Protein: SPXN
Spexin (NPQ) (Neuropeptide Q) (Spexin hormone) [Cleaved into: Spexin-1; Spexin-2 (NPQ 53-70)]

Gene: SPXN, SPX
Organism: Homo sapiens
Interactions: 32
UniProt ID: Q9BT56

Gene Ontology (top 5):
GO:0003084 - positive regulation of systemic arterial blood pressure
GO:0005184 - neuropeptide hormone activity
GO:0005615 - extracellular space
GO:0005737 - cytoplasm
GO:0010459 - negative regulation of heart rate

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

334232

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

0

High-throughput

0.513

High

535471

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.513

High

842987

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

0

High-throughput

0.513

High

846829

BTD
Biotinidase

1

0

High-throughput

0.513

High

1105769

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

0

High-throughput

0.513

High

1158077

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

1

0

High-throughput

0.513

High

1279505

CMKMT
Calmodulin-lysine N-methyltransferase

1

0

High-throughput

0.513

High

1387030

NMD3
60S ribosomal export protein NMD3

1

0

High-throughput

0.513

High

1394238

BOD1
Biorientation of chromosomes in cell division protein 1

1

0

High-throughput

0.513

High

247161

TBCD4
TBC1 domain family member 4

1

1

High-throughput

0.489

High

1244899

NCEH1
Neutral cholesterol ester hydrolase 1

1

1

High-throughput

0.489

High

1287254

TBCD1
TBC1 domain family member 1

1

1

High-throughput

0.489

High

423022

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

1234507

MRM1
rRNA methyltransferase 1, mitochondrial

2

0

High-throughput

0.316

High

215754

ERI3
ERI1 exoribonuclease 3

1

0

High-throughput

0.279

Low

284412

CLN5
Bis(monoacylglycero)phosphate synthase CLN5

1

0

High-throughput

0.279

Low

341354

ECEL1
Endothelin-converting enzyme-like 1

1

0

High-throughput

0.279

Low

479226

THIK
3-ketoacyl-CoA thiolase, peroxisomal

1

0

High-throughput

0.279

Low

907933

PLXA3
Plexin-A3

1

0

High-throughput

0.279

Low

1153788

NCOA1
Nuclear receptor coactivator 1

1

0

High-throughput

0.279

Low

1208377

WIPI3
WD repeat domain phosphoinositide-interacting protein 3

1

0

High-throughput

0.279

Low

1212529

CAF17
Iron-sulfur cluster assembly factor IBA57, mitochondrial

1

0

High-throughput

0.279

Low

1212688

GT253
Inactive glycosyltransferase 25 family member 3

1

0

High-throughput

0.279

Low

1248899

EST3
Carboxylesterase 3

1

0

High-throughput

0.279

Low

1333734

PCYXL
Prenylcysteine oxidase 1-like

1

0

High-throughput

0.279

Low

1346596

GRPE2
GrpE protein homolog 2, mitochondrial

1

0

High-throughput

0.279

Low

1396595

NAR5
Ecto-ADP-ribosyltransferase 5

1

0

High-throughput

0.279

Low

1413145

EFHD1
EF-hand domain-containing protein D1

1

0

High-throughput

0.279

Low

1413146

NELFA
Negative elongation factor A

1

0

High-throughput

0.279

Low

1413147

DEFM
Peptide deformylase, mitochondrial

1

0

High-throughput

0.279

Low

1413148

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.279

Low

1413149

SIA10
Type 2 lactosamine alpha-2,3-sialyltransferase

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025