Protein: NELFA
Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein)

Gene: NELFA
Organism: Homo sapiens
Interactions: 90
UniProt ID: Q9H3P2

Gene Ontology (top 5):
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0016604 - nuclear body

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1312170

NELFD
Negative elongation factor C/D

11

1

Small-scale

0.761

High

615591

NELFE
Negative elongation factor E

9

1

Small-scale

0.756

High

1360069

NELFB
Negative elongation factor B

7

1

Small-scale

0.748

High

130613

SPT5H
Transcription elongation factor SPT5

3

4

Small-scale

0.662

High

621743

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

1

Small-scale

0.628

High

807962

SMBP2
DNA-binding protein SMUBP-2

2

1

High-throughput

0.628

High

1432788

MCM9
DNA helicase MCM9

2

4

High-throughput

0.628

High

667449

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

1

Small-scale

0.624

High

723087

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

3

High-throughput

0.611

High

222203

NCK2
Cytoplasmic protein NCK2

2

14

High-throughput

0.606

High

1025293

CDK3
Cyclin-dependent kinase 3

2

3

High-throughput

0.606

High

1109389

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

1

High-throughput

0.606

High

1384265

SH3K1
SH3 domain-containing kinase-binding protein 1

2

11

High-throughput

0.606

High

1392054

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

2

1

High-throughput

0.606

High

260446

BRD4
Bromodomain-containing protein 4

2

6

High-throughput

0.584

High

373135

MYC
Myc proto-oncogene protein

2

10

High-throughput

0.584

High

827489

MLH1
DNA mismatch repair protein Mlh1

2

0

High-throughput

0.580

High

1307795

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

1

High-throughput

0.573

High

911677

NCBP2
Nuclear cap-binding protein subunit 2

2

4

High-throughput

0.571

High

414613

P53
Cellular tumor antigen p53

1

5

High-throughput

0.536

High

730234

1433B
14-3-3 protein beta/alpha

1

16

High-throughput

0.536

High

787785

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

1

High-throughput

0.536

High

867417

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

912230

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

1

High-throughput

0.536

High

990723

1433Z
14-3-3 protein zeta/delta

1

16

High-throughput

0.536

High

994374

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

1

High-throughput

0.536

High

1065427

SSRP1
FACT complex subunit SSRP1

1

5

High-throughput

0.536

High

1432787

PICK1
PRKCA-binding protein

1

1

High-throughput

0.536

High

770918

OPRM
Mu-type opioid receptor

1

2

High-throughput

0.532

High

887219

CEBPA
CCAAT/enhancer-binding protein alpha

1

7

High-throughput

0.527

High

608352

EGLN
Endoglin

1

0

High-throughput

0.513

High

621965

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.513

High

652411

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

0

High-throughput

0.513

High

912123

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.513

High

923537

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.513

High

959055

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.513

High

1050369

ICA69
Islet cell autoantigen 1

1

0

High-throughput

0.513

High

1066777

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.513

High

1385749

INT12
Integrator complex subunit 12

1

0

High-throughput

0.513

High

1411546

PYM1
Partner of Y14 and mago

1

0

High-throughput

0.513

High

1432794

AGO2
Protein argonaute-2

1

0

High-throughput

0.513

High

423153

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

388666

C1QA
Complement C1q subcomponent subunit A

1

5

High-throughput

0.489

High

1340104

ATLA2
Atlastin-2

1

1

High-throughput

0.489

High

132294

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

6

High-throughput

0.479

High

223329

PRC1
Protein regulator of cytokinesis 1

1

3

High-throughput

0.479

High

242910

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.479

High

502126

H2AZ
Histone H2A.Z

1

8

High-throughput

0.479

High

520372

ANDR
Androgen receptor

1

16

High-throughput

0.479

High

589669

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

696487

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

714422

PML
Protein PML

1

6

High-throughput

0.479

High

769161

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

981090

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.479

High

995816

ACTC
Actin, alpha cardiac muscle 1

1

2

High-throughput

0.479

High

1061144

SRSF1
Serine/arginine-rich splicing factor 1

1

2

High-throughput

0.479

High

1150177

TCEA2
Transcription elongation factor A protein 2

1

1

High-throughput

0.479

High

1201962

BRDT
Bromodomain testis-specific protein

1

9

High-throughput

0.479

High

1314417

SLX4
Structure-specific endonuclease subunit SLX4

1

9

High-throughput

0.479

High

1367261

ESR2
Estrogen receptor beta

1

16

High-throughput

0.479

High

1368118

HDAC2
Histone deacetylase 2

1

6

High-throughput

0.479

High

1368616

KAT6A
Histone acetyltransferase KAT6A

1

5

High-throughput

0.479

High

1432554

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

6

Small-scale

0.479

High

1432789

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

1432792

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1432793

XPO7
Exportin-7

1

3

High-throughput

0.479

High

1432795

ASF1A
Histone chaperone ASF1A

1

3

High-throughput

0.479

High

262569

MCE1
mRNA-capping enzyme

1

0

High-throughput

0.458

High

800099

COIL
Coilin

1

0

High-throughput

0.458

High

91550

C9J2Y9
DNA-directed RNA polymerase subunit beta

1

3

High-throughput

0.445

High

330314

VENTX
Homeobox protein VENTX

1

3

High-throughput

0.445

High

530372

TAU
Microtubule-associated protein tau

1

12

High-throughput

0.445

High

1194376

LARP7
La-related protein 7

1

2

Small-scale

0.445

High

412602

NTRK1
High affinity nerve growth factor receptor

1

8

High-throughput

0.437

High

762252

TRY3
Trypsin-3

1

1

High-throughput

0.437

High

1255517

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.437

High

1432791

HECW2
E3 ubiquitin-protein ligase HECW2

1

7

High-throughput

0.437

High

87568

SEHBP
Transcriptional regulator SEHBP

1

0

High-throughput

0.426

High

954742

SEM1
26S proteasome complex subunit SEM1

1

0

High-throughput

0.426

High

1292672

PRSR2
Proline and serine-rich protein 2

2

0

High-throughput

0.328

High

1406419

FEZ1
Fasciculation and elongation protein zeta-1

2

0

High-throughput

0.328

High

1432790

TMOD4
Tropomodulin-4

2

0

High-throughput

0.328

High

1316027

PRR22
Proline-rich protein 22

2

0

High-throughput

0.304

High

1294668

XYLT1
Xylosyltransferase 1

1

0

High-throughput

0.279

Low

1392170

RUSF1
RUS family member 1

1

0

High-throughput

0.279

Low

1413146

SPXN
Spexin

1

0

High-throughput

0.279

Low

420692

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

High-throughput

0.249

Low

1256925

SEML
Putative protein SEM1, isoform 2

1

0

High-throughput

0.249

Low

1330777

UBR7
Putative E3 ubiquitin-protein ligase UBR7

1

0

High-throughput

0.249

Low

1392585

S41A3
Solute carrier family 41 member 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025