Protein: CTIP
DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2)

Gene: CTIP, RBBP8
Organism: Homo sapiens
Interactions: 115
UniProt ID: Q99708

Gene Ontology (top 5):
GO:0000014 - single-stranded DNA endodeoxyribonuclease activity
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000724 - double-strand break repair via homologous recombination
GO:0001835 - blastocyst hatching
GO:0003684 - damaged DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1406584

CTIP
DNA endonuclease RBBP8

4

0

Small-scale

0.872

High

799433

BRCA1
Breast cancer type 1 susceptibility protein

36

2

Small-scale

0.770

High

1103340

CTBP1
C-terminal-binding protein 1

6

2

Small-scale

0.741

High

1065679

RBL2
Retinoblastoma-like protein 2

6

3

Small-scale

0.734

High

442795

RB
Retinoblastoma-associated protein

6

3

Small-scale

0.734

High

892926

MRE11
Double-strand break repair protein MRE11

10

0

Small-scale

0.722

High

262119

NBN
Nibrin

8

0

Small-scale

0.716

High

965504

LMO4
LIM domain transcription factor LMO4

4

2

Small-scale

0.703

High

1102238

ATM
Serine-protein kinase ATM

4

1

Small-scale

0.699

High

1406585

BARD1
BRCA1-associated RING domain protein 1

6

0

Small-scale

0.697

High

1369749

RAD50
DNA repair protein RAD50

6

0

Small-scale

0.692

High

1406587

FACD2
Fanconi anemia group D2 protein

4

0

Small-scale

0.675

High

1397870

KLH15
Kelch-like protein 15

3

0

Small-scale

0.659

High

941533

CTBP2
C-terminal-binding protein 2

3

2

Small-scale

0.658

High

1109366

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

1

High-throughput

0.646

High

1406599

EXO1
Exonuclease 1

3

0

Small-scale

0.639

High

1307774

SIAH1
E3 ubiquitin-protein ligase SIAH1

2

1

Small-scale

0.631

High

211590

SIAH2
E3 ubiquitin-protein ligase SIAH2

2

1

Small-scale

0.629

High

291954

WDHD1
WD repeat and HMG-box DNA-binding protein 1

2

1

Small-scale

0.624

High

704987

RBL1
Retinoblastoma-like protein 1

2

3

Small-scale

0.613

High

1406596

SCOC
Short coiled-coil protein

2

0

High-throughput

0.602

High

1094616

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

2

0

Small-scale

0.598

High

996306

EF1A1
Elongation factor 1-alpha 1

2

0

Small-scale

0.588

High

315931

RECQ4
ATP-dependent DNA helicase Q4

2

1

High-throughput

0.584

High

993726

UBC9
SUMO-conjugating enzyme UBC9

2

0

Small-scale

0.577

High

682092

RBTN1
Rhombotin-1

1

2

High-throughput

0.573

High

508501

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

0

Small-scale

0.569

High

1008306

PRKDC
DNA-dependent protein kinase catalytic subunit

2

1

Small-scale

0.563

High

283134

PSIP1
PC4 and SFRS1-interacting protein

1

1

Small-scale

0.561

High

1406598

FZR1
Fizzy-related protein homolog

1

1

Small-scale

0.561

High

870158

LIMS1
LIM and senescent cell antigen-like-containing domain protein 1

2

1

High-throughput

0.555

High

551220

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.549

High

903089

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2

1

0

Small-scale

0.537

High

1005018

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

Small-scale

0.537

High

1114110

CUL3
Cullin-3

1

0

Small-scale

0.537

High

1197547

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

0

Small-scale

0.537

High

1324586

PIAS4
E3 SUMO-protein ligase PIAS4

1

0

Small-scale

0.537

High

1403509

MINT
Msx2-interacting protein

1

0

Small-scale

0.537

High

1341006

THOC2
THO complex subunit 2

1

1

High-throughput

0.536

High

401361

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.518

High

533746

CLUS
Clusterin

1

0

High-throughput

0.518

High

853906

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

0

High-throughput

0.518

High

900479

FXR2
RNA-binding protein FXR2

1

0

High-throughput

0.518

High

1392860

NTAQ1
Protein N-terminal glutamine amidohydrolase

1

0

High-throughput

0.518

High

1406594

RGS17
Regulator of G-protein signaling 17

1

0

High-throughput

0.518

High

1406601

NEMO
NF-kappa-B essential modulator

1

0

High-throughput

0.518

High

553052

PIP
Prolactin-inducible protein

1

0

High-throughput

0.513

High

761840

HSP74
Heat shock 70 kDa protein 4

1

0

High-throughput

0.513

High

920230

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.513

High

1178624

KIF7
Kinesin-like protein KIF7

1

0

High-throughput

0.513

High

1294953

PALB2
Partner and localizer of BRCA2

1

0

Small-scale

0.513

High

1401490

UIMC1
BRCA1-A complex subunit RAP80

1

0

Small-scale

0.513

High

1406592

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

Small-scale

0.513

High

1406593

AATF
Protein AATF

1

0

Small-scale

0.484

High

1364223

TOPB1
DNA topoisomerase 2-binding protein 1

1

1

High-throughput

0.481

High

1209557

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.480

High

591807

H2AX
Histone H2AX

1

0

Small-scale

0.479

High

246900

KDM1A
Lysine-specific histone demethylase 1A

1

2

High-throughput

0.479

High

926400

BLM
RecQ-like DNA helicase BLM

1

1

Small-scale

0.479

High

1048076

TLE3
Transducin-like enhancer protein 3

1

1

High-throughput

0.479

High

1110028

HDAC1
Histone deacetylase 1

1

1

High-throughput

0.479

High

1278796

HDGR2
Hepatoma-derived growth factor-related protein 2

1

2

Small-scale

0.479

High

1338925

NUP43
Nucleoporin Nup43

1

1

High-throughput

0.479

High

1340793

COP1
E3 ubiquitin-protein ligase COP1

1

1

High-throughput

0.479

High

1368082

HDAC2
Histone deacetylase 2

1

1

Small-scale

0.479

High

1390438

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

1

Small-scale

0.479

High

1406591

PDLI7
PDZ and LIM domain protein 7

1

1

Small-scale

0.479

High

129364

MEN1
Menin

1

0

High-throughput

0.458

High

140416

SDCB1
Syntenin-1

1

0

Small-scale

0.458

High

167527

TX1B3
Tax1-binding protein 3

1

0

Small-scale

0.458

High

238944

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

1

0

Small-scale

0.458

High

277192

ZN217
Zinc finger protein 217

1

0

Small-scale

0.458

High

341660

EYA4
Protein phosphatase EYA4

1

0

High-throughput

0.458

High

414486

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

468732

HS90B
Heat shock protein HSP 90-beta

1

0

Small-scale

0.458

High

535450

BIP
Endoplasmic reticulum chaperone BiP

1

0

Small-scale

0.458

High

558359

XRCC6
X-ray repair cross-complementing protein 6

1

0

Small-scale

0.458

High

589506

RFA2
Replication protein A 32 kDa subunit

1

0

Small-scale

0.458

High

617732

XRCC1
DNA repair protein XRCC1

1

0

Small-scale

0.458

High

684508

CTNA2
Catenin alpha-2

1

0

Small-scale

0.458

High

823977

PBX3
Pre-B-cell leukemia transcription factor 3

1

0

Small-scale

0.458

High

916028

NUP98
Nuclear pore complex protein Nup98-Nup96

1

0

High-throughput

0.458

High

980205

H4
Histone H4

1

0

Small-scale

0.458

High

1028358

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

1042915

ERCC6
DNA excision repair protein ERCC-6

1

0

Small-scale

0.458

High

1103060

PPIL2
RING-type E3 ubiquitin-protein ligase PPIL2

1

0

Small-scale

0.458

High

1104656

IKZF1
DNA-binding protein Ikaros

1

0

Small-scale

0.458

High

1248947

ABRX1
BRCA1-A complex subunit Abraxas 1

1

0

Small-scale

0.458

High

1279416

DPOLN
DNA polymerase nu

1

0

Small-scale

0.458

High

1288083

SAPC2
Suppressor APC domain-containing protein 2

1

0

Small-scale

0.458

High

1357982

RN138
E3 ubiquitin-protein ligase RNF138

1

0

Small-scale

0.458

High

1370620

GPKOW
G-patch domain and KOW motifs-containing protein

1

0

Small-scale

0.458

High

1384425

PF21A
PHD finger protein 21A

1

0

High-throughput

0.458

High

1387519

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

0

High-throughput

0.458

High

1388627

SPDLY
Protein Spindly

1

0

High-throughput

0.458

High

1406589

ZN350
Zinc finger protein 350

1

0

Small-scale

0.458

High

1406595

XPO7
Exportin-7

1

0

High-throughput

0.458

High

1406597

RCOR1
REST corepressor 1

1

0

High-throughput

0.458

High

1406600

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

Small-scale

0.458

High

1406590

PELI2
E3 ubiquitin-protein ligase pellino homolog 2

1

1

Small-scale

0.439

High

1406586

ERP44
Endoplasmic reticulum resident protein 44

2

0

High-throughput

0.328

High

1156927

IBP7
Insulin-like growth factor-binding protein 7

1

0

High-throughput

0.282

High

1308387

HID1
Protein HID1

1

0

High-throughput

0.282

High

1380428

TMM54
Transmembrane protein 54

1

0

High-throughput

0.282

High

1406588

TMG4
Transmembrane gamma-carboxyglutamic acid protein 4

1

0

High-throughput

0.282

High

391424

FRIL
Ferritin light chain

1

0

High-throughput

0.279

Low

126175

AP3B1
AP-3 complex subunit beta-1

1

0

Small-scale

0.249

Low

643548

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

0

Small-scale

0.249

Low

948014

DEF1
Neutrophil defensin 1

1

0

Small-scale

0.249

Low

1241940

FBX42
F-box only protein 42

1

0

High-throughput

0.249

Low

1348185

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

1351451

BRX1
Ribosome biogenesis protein BRX1 homolog

1

0

Small-scale

0.249

Low

58911

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

0

High-throughput

0.232

Low

1402888

CK5P2
CDK5 regulatory subunit-associated protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025