Protein: HNS
DNA-binding protein H-NS (Heat-stable nucleoid-structuring protein) (Histone-like protein HLP-II) (Protein B1) (Protein H1)

Gene: HNS
Organism: Escherichia coli K-12
Interactions: 71
UniProt ID: P0ACF8

Gene Ontology (top 5):
GO:0000976 - transcription cis-regulatory region binding
GO:0001217 - DNA-binding transcription repressor activity
GO:0003680 - minor groove of adenine-thymine-rich DNA binding
GO:0003681 - bent DNA binding
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

499143

STPA
DNA-binding protein StpA

4

6

High-throughput

0.900

High

499142

HNS
DNA-binding protein H-NS

3

6

Small-scale

0.878

High

499171

CNU
OriC-binding nucleoid-associated protein

3

1

Small-scale

0.839

High

499034

HHA
Hemolysin expression-modulating protein Hha

1

1

Small-scale

0.724

High

499046

DBHA
DNA-binding protein HU-alpha

2

1

High-throughput

0.588

High

499102

DBHB
DNA-binding protein HU-beta

2

1

High-throughput

0.588

High

494932

TIG
Trigger factor

2

0

High-throughput

0.563

High

499168

RL24
Large ribosomal subunit protein uL24

2

0

High-throughput

0.563

High

499174

NFI
Endonuclease V

2

0

High-throughput

0.563

High

499152

SSB
Single-stranded DNA-binding protein

2

0

High-throughput

0.547

High

495329

UVRB
UvrABC system protein B

2

1

High-throughput

0.537

High

491614

KPRS
Ribose-phosphate pyrophosphokinase

1

1

High-throughput

0.536

High

495181

YEEN
Probable transcriptional regulatory protein YeeN

1

1

High-throughput

0.536

High

493329

RS12
Small ribosomal subunit protein uS12

1

0

High-throughput

0.513

High

498089

YCED
Large ribosomal RNA subunit accumulation protein YceD

1

0

High-throughput

0.513

High

499148

RL14
Large ribosomal subunit protein uL14

1

0

High-throughput

0.513

High

499158

PEPT
Peptidase T

1

0

High-throughput

0.513

High

499160

YIIS
UPF0381 protein YiiS

1

0

High-throughput

0.513

High

499166

OBG
GTPase ObgE/CgtA

1

0

High-throughput

0.513

High

499170

FLAV
Flavodoxin 1

1

0

High-throughput

0.513

High

499175

SXY
Protein Sxy

1

0

High-throughput

0.513

High

499182

YDJF
Uncharacterized HTH-type transcriptional regulator YdjF

1

0

High-throughput

0.513

High

499144

ROB
Right origin-binding protein

1

1

High-throughput

0.500

High

499157

SCPA
Methylmalonyl-CoA mutase

1

1

High-throughput

0.489

High

499161

TORA
Trimethylamine-N-oxide reductase 1

1

1

High-throughput

0.489

High

499173

YQCA
Flavodoxin YqcA

1

1

High-throughput

0.489

High

499154

PUR4
Phosphoribosylformylglycinamidine synthase

1

0

High-throughput

0.479

High

499156

MAK
Fructokinase

1

0

High-throughput

0.479

High

499162

TKT2
Transketolase 2

1

2

High-throughput

0.479

High

361749

PHSM
Maltodextrin phosphorylase

1

0

High-throughput

0.464

High

365874

DPO1
DNA polymerase I

1

0

High-throughput

0.464

High

395154

UVRD
DNA helicase II

1

0

High-throughput

0.464

High

444296

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.464

High

492234

PYRH
Uridylate kinase

1

0

High-throughput

0.464

High

495812

RPOC
DNA-directed RNA polymerase subunit beta'

1

0

High-throughput

0.464

High

495898

RPOB
DNA-directed RNA polymerase subunit beta

1

0

High-throughput

0.464

High

498550

HOLE
DNA polymerase III subunit theta

1

0

High-throughput

0.464

High

499150

ODP1
Pyruvate dehydrogenase E1 component

1

0

High-throughput

0.464

High

499155

MALQ
4-alpha-glucanotransferase

1

0

High-throughput

0.464

High

499169

RL22
Large ribosomal subunit protein uL22

1

0

High-throughput

0.464

High

499177

YNBC
Uncharacterized protein YnbC

1

0

High-throughput

0.464

High

368267

THRC
Threonine synthase

1

0

High-throughput

0.458

High

483707

PUTA
Bifunctional protein PutA [Includes: Proline dehydrogenase

1

0

High-throughput

0.458

High

492179

PURA
Adenylosuccinate synthetase

1

0

High-throughput

0.458

High

498637

EXBB
Biopolymer transport protein ExbB

1

0

High-throughput

0.458

High

499159

YAFC
Uncharacterized HTH-type transcriptional regulator YafC

1

0

High-throughput

0.458

High

499178

KDGR
HTH-type transcriptional regulator KdgR

1

0

High-throughput

0.458

High

499180

YFFS
Uncharacterized protein YffS

1

0

High-throughput

0.458

High

498720

FLIG
Flagellar motor switch protein FliG

1

1

Small-scale

0.437

High

499167

TORZ
Trimethylamine-N-oxide reductase 2

1

1

High-throughput

0.437

High

499153

SECA
Protein translocase subunit SecA

2

0

High-throughput

0.307

High

450109

PRIB
Replication restart protein PriB

1

0

High-throughput

0.279

Low

489151

YIDB
Uncharacterized protein YidB

1

0

High-throughput

0.279

Low

494728

RUVC
Crossover junction endodeoxyribonuclease RuvC

1

0

High-throughput

0.279

Low

495421

YQGF
Putative pre-16S rRNA nuclease

1

0

High-throughput

0.279

Low

499146

YEJG
Uncharacterized protein YejG

1

0

High-throughput

0.279

Low

499163

YCHJ
UPF0225 protein YchJ

1

0

High-throughput

0.279

Low

499176

VXIS
Prophage excisionase-like protein

1

0

High-throughput

0.279

Low

499181

PAAY
Phenylacetic acid degradation protein PaaY

1

0

High-throughput

0.279

Low

499151

YBBO
Uncharacterized oxidoreductase YbbO

1

0

High-throughput

0.261

Low

493733

RS2
Small ribosomal subunit protein uS2

1

0

High-throughput

0.253

Low

499149

CEDA
Cell division activator CedA

1

0

High-throughput

0.253

Low

393876

PBPA
Penicillin-binding protein 1A

1

0

High-throughput

0.249

Low

432126

APAH
Bis(5'-nucleosyl)-tetraphosphatase [symmetrical]

1

0

High-throughput

0.249

Low

499145

LAPA
Lipopolysaccharide assembly protein A

1

0

High-throughput

0.249

Low

499147

NLPD
Murein hydrolase activator NlpD

1

0

High-throughput

0.249

Low

499164

WBBK
Putative glycosyltransferase WbbK

1

0

High-throughput

0.249

Low

499165

AG43
Antigen 43

1

0

High-throughput

0.249

Low

499172

YODD
Uncharacterized protein YodD

1

0

High-throughput

0.249

Low

499179

YEGH
UPF0053 protein YegH

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025