Protein: COM1
DNA endonuclease SAE2 (EC 3.1.-.-) (Completion of meiotic recombination protein 1) (Sporulation in the absence of SPO11 protein 2)

Gene: COM1, SAE2
Organism: Saccharomyces cerevisiae S288C
Interactions: 32
UniProt ID: P46946

Gene Ontology (top 5):
GO:0000014 - single-stranded DNA endodeoxyribonuclease activity
GO:0000706 - meiotic DNA double-strand break processing
GO:0000723 - telomere maintenance
GO:0000729 - DNA double-strand break processing
GO:0003690 - double-stranded DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

555264

RAD50
DNA repair protein RAD50

6

0

Small-scale

0.698

High

745525

MRE11
Double-strand break repair protein MRE11

5

0

Small-scale

0.685

High

863080

COM1
DNA endonuclease SAE2

5

0

Small-scale

0.685

High

751049

XRS2
DNA repair protein XRS2

4

0

Small-scale

0.663

High

444857

SIR3
Regulatory protein SIR3

2

0

Small-scale

0.613

High

364607

CDK1
Cyclin-dependent kinase 1

2

0

Small-scale

0.577

High

805464

DMA1
E3 ubiquitin-protein ligase DMA1

1

1

Small-scale

0.527

High

809083

DUN1
DNA damage response protein kinase DUN1

1

1

Small-scale

0.527

High

863081

DMA2
E3 ubiquitin-protein ligase DMA2

1

1

Small-scale

0.527

High

863083

IMA1
Importin subunit alpha

1

0

High-throughput

0.518

High

722048

XPO1
Exportin-1

1

0

High-throughput

0.513

High

646450

RAD53
Serine/threonine-protein kinase RAD53

1

0

Small-scale

0.505

High

469999

FUMH
Fumarate hydratase, mitochondrial

1

0

Small-scale

0.504

High

739980

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

0

Small-scale

0.504

High

440953

CDC7
Cell division control protein 7

1

1

Small-scale

0.501

High

814222

RV167
Reduced viability upon starvation protein 167

1

0

High-throughput

0.493

High

863082

AP2S
AP-2 complex subunit sigma

1

0

High-throughput

0.486

High

734267

DBF4
DDK kinase regulatory subunit DBF4

1

0

Small-scale

0.480

High

793404

ATM
Serine/threonine-protein kinase TEL1

1

0

Small-scale

0.480

High

667102

CG22
G2/mitotic-specific cyclin-2

1

1

Small-scale

0.479

High

667140

CG23
G2/mitotic-specific cyclin-3

1

1

Small-scale

0.479

High

557739

SRS2
ATP-dependent DNA helicase SRS2

1

0

Small-scale

0.460

High

806113

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2 [Includes: DNA replication nuclease DNA2

1

0

Small-scale

0.460

High

863084

NHEJ1
Non-homologous end-joining protein 1

1

0

Small-scale

0.460

High

445350

CDC31
Cell division control protein 31

1

0

High-throughput

0.458

High

826614

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

524360

HSP71
Heat shock protein SSA1

1

0

High-throughput

0.426

High

545348

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

863085

SMT3
Ubiquitin-like protein SMT3

1

0

Small-scale

0.391

High

678883

CSM1
Monopolin complex subunit CSM1

1

0

High-throughput

0.265

Low

738666

EI2BB
Translation initiation factor eIF2B subunit beta

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025