Protein: MRE11
Double-strand break repair protein MRE11 (EC 3.1.-.-)

Gene: MRE11
Organism: Saccharomyces cerevisiae S288C
Interactions: 50
UniProt ID: P32829

Gene Ontology (top 5):
GO:0000014 - single-stranded DNA endodeoxyribonuclease activity
GO:0000723 - telomere maintenance
GO:0000724 - double-strand break repair via homologous recombination
GO:0000727 - double-strand break repair via break-induced replication
GO:0000729 - DNA double-strand break processing

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

555240

RAD50
DNA repair protein RAD50

36

6

Small-scale

0.995

High

745514

MRE11
Double-strand break repair protein MRE11

6

4

Small-scale

0.933

High

745515

XRS2
DNA repair protein XRS2

34

0

Small-scale

0.737

High

745525

COM1
DNA endonuclease SAE2

5

0

Small-scale

0.685

High

745517

SGS1
ATP-dependent helicase SGS1

3

3

Small-scale

0.653

High

745542

SMT3
Ubiquitin-like protein SMT3

3

2

Small-scale

0.651

High

557686

SRS2
ATP-dependent DNA helicase SRS2

2

0

Small-scale

0.606

High

745518

ATM
Serine/threonine-protein kinase TEL1

2

6

Small-scale

0.595

High

745526

UBC9
SUMO-conjugating enzyme UBC9

2

2

Small-scale

0.584

High

745521

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2 [Includes: DNA replication nuclease DNA2

2

0

Small-scale

0.581

High

745536

RIF2
Protein RIF2

2

0

Small-scale

0.577

High

392459

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.575

High

745535

NHEJ1
Non-homologous end-joining protein 1

2

0

Small-scale

0.559

High

745541

SIZ2
E3 SUMO-protein ligase SIZ2

2

0

Small-scale

0.559

High

745528

RSC1
Chromatin structure-remodeling complex subunit RSC1

1

4

Small-scale

0.552

High

745537

RSC2
Chromatin structure-remodeling complex subunit RSC2

1

4

Small-scale

0.552

High

721796

XPO1
Exportin-1

1

0

High-throughput

0.513

High

745534

CST9
Chromosome stability protein 9

1

0

Small-scale

0.512

High

745540

MSH5
MutS protein homolog 5

1

2

High-throughput

0.508

High

745522

REV7
DNA polymerase zeta processivity subunit

1

0

Small-scale

0.504

High

364430

CDK1
Cyclin-dependent kinase 1

1

1

Small-scale

0.501

High

675281

DMC1
Meiotic recombination protein DMC1

1

0

High-throughput

0.493

High

690735

DPB3
DNA polymerase epsilon subunit C

1

0

High-throughput

0.493

High

745523

IFH1
Protein IFH1

1

0

High-throughput

0.493

High

745539

FCF2
rRNA-processing protein FCF2

1

0

High-throughput

0.493

High

745530

FAP1
FKBP12-associated protein 1

1

0

High-throughput

0.486

High

444759

SIR2
NAD-dependent histone deacetylase SIR2

1

2

Small-scale

0.481

High

647735

RFA1
Replication factor A protein 1

1

1

Small-scale

0.481

High

745532

KU80
ATP-dependent DNA helicase II subunit 2

1

1

Small-scale

0.481

High

745538

DNLI4
DNA ligase 4

1

1

Small-scale

0.481

High

654576

SPO11
Meiosis-specific protein SPO11

1

0

Small-scale

0.480

High

533472

RAD18
Postreplication repair E3 ubiquitin-protein ligase RAD18

1

1

Small-scale

0.479

High

654712

SPA2
Protein SPA2

1

2

High-throughput

0.470

High

745529

APC1
Anaphase-promoting complex subunit 1

1

0

High-throughput

0.460

High

745533

SPC24
Kinetochore protein SPC24

1

0

Small-scale

0.460

High

743000

SWI3
SWI/SNF complex subunit SWI3

1

0

Small-scale

0.458

High

523439

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.445

High

526247

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

544262

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

670505

SIS1
Protein SIS1

1

1

High-throughput

0.445

High

745520

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.445

High

639485

RE107
Recombination protein 107

1

0

Small-scale

0.438

High

745516

RE104
Meiotic recombination protein REC104

1

0

Small-scale

0.438

High

745531

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

5

Small-scale

0.437

High

675844

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.426

High

745527

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.426

High

745519

YBE4
Uncharacterized protein YBL044W

1

0

High-throughput

0.269

Low

745524

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.269

Low

613756

MDM10
Mitochondrial distribution and morphology protein 10

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025