Protein: RAD50
DNA repair protein RAD50 (EC 3.6.-.-) (153 kDa protein)

Gene: RAD50
Organism: Saccharomyces cerevisiae S288C
Interactions: 83
UniProt ID: P12753

Gene Ontology (top 5):
GO:0000722 - telomere maintenance via recombination
GO:0000723 - telomere maintenance
GO:0000794 - condensed nuclear chromosome
GO:0003690 - double-stranded DNA binding
GO:0003691 - double-stranded telomeric DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

555240

MRE11
Double-strand break repair protein MRE11

36

6

Small-scale

0.995

High

555219

RAD50
DNA repair protein RAD50

3

16

Small-scale

0.847

High

555244

XRS2
DNA repair protein XRS2

11

0

Small-scale

0.723

High

555264

COM1
DNA endonuclease SAE2

6

0

Small-scale

0.698

High

555247

ATM
Serine/threonine-protein kinase TEL1

4

13

Small-scale

0.694

High

555276

RIF2
Protein RIF2

4

0

Small-scale

0.668

High

555242

SMC1
Structural maintenance of chromosomes protein 1

1

17

High-throughput

0.656

High

555243

PRS6B
26S proteasome regulatory subunit 6B homolog

2

1

High-throughput

0.628

High

555282

SMC6
Structural maintenance of chromosomes protein 6

1

18

High-throughput

0.618

High

555246

PP2C3
Protein phosphatase 2C homolog 3

2

0

High-throughput

0.595

High

481450

HSP73
Heat shock protein SSA3

2

8

High-throughput

0.588

High

555254

HSP7E
Heat shock protein SSC3, mitochondrial

2

8

High-throughput

0.588

High

392118

HSP82
ATP-dependent molecular chaperone HSP82

2

8

High-throughput

0.584

High

555233

MAS5
Mitochondrial protein import protein MAS5

2

5

High-throughput

0.584

High

555265

NNF1
Kinetochore-associated protein NNF1

2

0

High-throughput

0.570

High

555279

RPN8
26S proteasome regulatory subunit RPN8

2

4

High-throughput

0.558

High

555220

YAK1
Dual specificity protein kinase YAK1

1

20

High-throughput

0.536

High

555225

VATA
V-type proton ATPase catalytic subunit A

1

5

High-throughput

0.536

High

555232

SSK22
Serine/threonine-protein kinase SSK22

1

11

High-throughput

0.536

High

555250

DUN1
DNA damage response protein kinase DUN1

1

16

High-throughput

0.536

High

555259

MAM33
Mitochondrial acidic protein MAM33

1

1

High-throughput

0.536

High

555263

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

6

High-throughput

0.536

High

555272

PRS8
26S proteasome regulatory subunit 8 homolog

1

2

High-throughput

0.536

High

555228

RFA1
Replication factor A protein 1

1

6

Small-scale

0.527

High

358948

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

2

High-throughput

0.515

High

518182

IF4A
ATP-dependent RNA helicase eIF4A

1

3

High-throughput

0.515

High

555223

EF3A
Elongation factor 3A

1

1

High-throughput

0.515

High

555281

NOP56
Nucleolar protein 56

1

1

High-throughput

0.515

High

555226

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.513

High

555255

IES5
Ino eighty subunit 5

1

0

High-throughput

0.513

High

555269

ORN
Oligoribonuclease, mitochondrial

1

0

High-throughput

0.513

High

555245

NUF2
Kinetochore protein NUF2

1

5

High-throughput

0.508

High

555249

REV7
DNA polymerase zeta processivity subunit

1

0

Small-scale

0.504

High

366903

ATPB
ATP synthase subunit beta, mitochondrial

1

4

High-throughput

0.500

High

555221

VATB
V-type proton ATPase subunit B

1

4

High-throughput

0.500

High

555222

BIP
Endoplasmic reticulum chaperone BiP

1

8

High-throughput

0.500

High

555230

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.493

High

555248

SLT11
Pre-mRNA-splicing factor SLT11

1

0

High-throughput

0.493

High

555239

VATD
V-type proton ATPase subunit D

1

1

High-throughput

0.489

High

555262

COPB2
Coatomer subunit beta'

1

8

High-throughput

0.489

High

370453

ATIF
F(1)-ATPase inhibitor IF(1), mitochondrial

1

0

High-throughput

0.486

High

555275

SPC24
Kinetochore protein SPC24

1

0

High-throughput

0.486

High

555277

HDA2
HDA1 complex subunit 2

1

0

High-throughput

0.486

High

555227

KIN3
Serine/threonine-protein kinase KIN3

1

20

High-throughput

0.481

High

555234

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

1

High-throughput

0.481

High

408276

GAL1
Galactokinase

1

0

High-throughput

0.479

High

425099

OTC
Ornithine carbamoyltransferase

1

0

High-throughput

0.479

High

450509

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.479

High

554986

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.479

High

555258

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.479

High

555235

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

555267

PRS10
26S proteasome subunit RPT4

1

7

High-throughput

0.479

High

555268

APJ1
J domain-containing protein APJ1

1

6

High-throughput

0.479

High

555270

CDC14
Tyrosine-protein phosphatase CDC14

1

12

Small-scale

0.479

High

555271

CTF4
DNA polymerase alpha-binding protein

1

8

High-throughput

0.479

High

555274

PDS5
Sister chromatid cohesion protein PDS5

1

9

High-throughput

0.479

High

555236

EF2
Elongation factor 2

1

6

High-throughput

0.470

High

555251

END3
Actin cytoskeleton-regulatory complex protein END3

1

3

High-throughput

0.464

High

555266

KNL1
Outer kinetochore KNL1 complex subunit SPC105

1

0

High-throughput

0.460

High

358007

CYB2
L-lactate dehydrogenase

1

0

High-throughput

0.458

High

555224

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.458

High

555273

DIG2
Down-regulator of invasive growth 2

1

0

High-throughput

0.458

High

522882

HSP71
Heat shock protein SSA1

1

8

High-throughput

0.445

High

525771

HSP72
Heat shock protein SSA2

1

8

High-throughput

0.445

High

543628

SSB1
Ribosome-associated molecular chaperone SSB1

1

8

High-throughput

0.445

High

555231

SIS1
Protein SIS1

1

4

High-throughput

0.445

High

555237

HSP7F
Heat shock protein homolog SSE1

1

11

High-throughput

0.445

High

555238

HSP79
Heat shock protein homolog SSE2

1

11

High-throughput

0.445

High

555252

TCPD
T-complex protein 1 subunit delta

1

1

High-throughput

0.445

High

555253

XDJ1
DnaJ protein homolog XDJ1

1

5

High-throughput

0.445

High

555256

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.445

High

555260

DJP1
DnaJ-like protein 1

1

4

High-throughput

0.445

High

555241

SSO1
Protein SSO1

1

3

High-throughput

0.439

High

445308

CDC31
Cell division control protein 31

1

2

Small-scale

0.437

High

555283

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.426

High

555280

SMT3
Ubiquitin-like protein SMT3

1

3

Small-scale

0.408

High

446201

PHSG
Glycogen phosphorylase

1

0

High-throughput

0.279

Low

555261

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.279

Low

408544

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

0

High-throughput

0.261

Low

555229

URE2
Transcriptional regulator URE2

1

0

High-throughput

0.249

Low

555278

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

555257

JEM1
DnaJ-like chaperone JEM1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025