Protein: HOLC
DNA polymerase III subunit chi (EC 2.7.7.7) (Accessory clamp loader complex subunit chi) (Replication clamp loader subunit HolC)

Gene: HOLC
Organism: Escherichia coli K-12
Interactions: 43
UniProt ID: P28905

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003887 - DNA-directed DNA polymerase activity
GO:0006260 - DNA replication
GO:0006261 - DNA-templated DNA replication
GO:0009314 - response to radiation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

704179

HOLD
DNA polymerase III subunit psi

10

0

Small-scale

0.929

High

704172

HOLB
DNA polymerase III subunit delta'

5

1

Small-scale

0.721

High

445425

DPO3X
DNA polymerase III subunit tau

7

0

Small-scale

0.715

High

501536

SSB
Single-stranded DNA-binding protein

5

0

Small-scale

0.676

High

704149

HOLA
DNA polymerase III subunit delta

2

0

Small-scale

0.607

High

499694

PINR
Serine recombinase PinR

2

0

High-throughput

0.563

High

705895

RL4
Large ribosomal subunit protein uL4

2

0

High-throughput

0.563

High

444313

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.561

High

571328

TOP3
DNA topoisomerase 3

1

1

High-throughput

0.561

High

395126

DPO3E
DNA polymerase III subunit epsilon

1

0

High-throughput

0.537

High

522208

DPO3A
DNA polymerase III subunit alpha

1

0

High-throughput

0.537

High

578358

RECQ
ATP-dependent DNA helicase RecQ

1

0

High-throughput

0.537

High

609169

PRIA
Replication restart protein PriA

1

0

High-throughput

0.537

High

705899

YOAA
ATP-dependent DNA helicase YoaA

1

0

High-throughput

0.537

High

705890

HOLC
DNA polymerase III subunit chi

1

0

High-throughput

0.518

High

489240

UVRA
UvrABC system protein A

1

0

High-throughput

0.513

High

705898

INTE
Prophage integrase IntE

1

0

High-throughput

0.513

High

491168

DNAK
Chaperone protein DnaK

1

0

High-throughput

0.464

High

496911

LON
Lon protease

1

0

High-throughput

0.464

High

498565

HOLE
DNA polymerase III subunit theta

1

0

High-throughput

0.464

High

492534

RL7
Large ribosomal subunit protein bL12

2

0

High-throughput

0.307

High

492627

RL19
Large ribosomal subunit protein bL19

2

0

High-throughput

0.307

High

492962

RL28
Large ribosomal subunit protein bL28

2

0

High-throughput

0.307

High

493044

RL29
Large ribosomal subunit protein uL29

2

0

High-throughput

0.307

High

493105

RL33
Large ribosomal subunit protein bL33

2

0

High-throughput

0.307

High

501331

RS14
Small ribosomal subunit protein uS14

2

0

High-throughput

0.307

High

705893

RL2
Large ribosomal subunit protein uL2

2

0

High-throughput

0.307

High

705892

BLR
Divisome-associated membrane protein Blr

1

0

High-throughput

0.282

High

420225

EX1
Exodeoxyribonuclease I

1

0

High-throughput

0.279

Low

493791

RS2
Small ribosomal subunit protein uS2

1

0

High-throughput

0.279

Low

494309

RS5
Small ribosomal subunit protein uS5

1

0

High-throughput

0.279

Low

521481

SECA
Protein translocase subunit SecA

1

0

High-throughput

0.279

Low

690647

GLND
Bifunctional uridylyltransferase/uridylyl-removing enzyme

1

0

High-throughput

0.279

Low

705891

RLMJ
Ribosomal RNA large subunit methyltransferase J

1

0

High-throughput

0.279

Low

705894

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.279

Low

705897

HIGB
mRNA interferase toxin HigB

1

0

High-throughput

0.279

Low

493262

RS10
Small ribosomal subunit protein uS10

1

0

High-throughput

0.253

Low

498393

CLPA
ATP-dependent Clp protease ATP-binding subunit ClpA

1

0

High-throughput

0.253

Low

705896

RL22
Large ribosomal subunit protein uL22

1

0

High-throughput

0.253

Low

491974

NUSB
Transcription antitermination protein NusB

1

0

High-throughput

0.249

Low

495097

TRMD
tRNA

1

0

High-throughput

0.249

Low

489252

UBIB
Probable protein kinase UbiB

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025