Protein: RL21
Large ribosomal subunit protein bL21 (50S ribosomal protein L21)

Gene: RL21, rplU
Organism: Escherichia coli K-12
Interactions: 102
UniProt ID: P0AG48

Gene Ontology (top 5):
GO:0002181 - cytoplasmic translation
GO:0003735 - structural constituent of ribosome
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0019843 - rRNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

497623

RLUC
Ribosomal large subunit pseudouridine synthase C

3

1

High-throughput

0.657

High

495484

RHLB
ATP-dependent RNA helicase RhlB

2

1

High-throughput

0.588

High

497271

ULAR
HTH-type transcriptional regulator UlaR

2

1

High-throughput

0.588

High

498376

CLPA
ATP-dependent Clp protease ATP-binding subunit ClpA

2

1

High-throughput

0.588

High

499350

ALLR
HTH-type transcriptional repressor AllR

2

1

High-throughput

0.588

High

501239

LPXD
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase

2

2

High-throughput

0.588

High

501248

RLUB
Ribosomal large subunit pseudouridine synthase B

2

1

High-throughput

0.588

High

494621

RPOA
DNA-directed RNA polymerase subunit alpha

2

0

High-throughput

0.576

High

495360

UVRC
UvrABC system protein C

2

0

High-throughput

0.576

High

501231

DPO3A
DNA polymerase III subunit alpha

2

0

High-throughput

0.576

High

361750

PHSM
Maltodextrin phosphorylase

2

0

High-throughput

0.563

High

365829

RPOD
RNA polymerase sigma factor RpoD

2

0

High-throughput

0.563

High

368957

SYGA
Glycine--tRNA ligase alpha subunit

2

0

High-throughput

0.563

High

421118

PNP
Polyribonucleotide nucleotidyltransferase

2

0

High-throughput

0.563

High

491940

RPPH
RNA pyrophosphohydrolase

2

0

High-throughput

0.563

High

496723

PHOL
PhoH-like protein

2

0

High-throughput

0.563

High

496899

LON
Lon protease

2

0

High-throughput

0.563

High

497986

YBCJ
Putative RNA-binding protein YbcJ

2

0

High-throughput

0.563

High

499922

RL23
Large ribosomal subunit protein uL23

2

0

High-throughput

0.563

High

500483

SKP
Chaperone protein Skp

2

0

High-throughput

0.563

High

501094

SPOT
Bifunctional

2

0

High-throughput

0.563

High

501228

YHBY
RNA-binding protein YhbY

2

0

High-throughput

0.563

High

501232

SELB
Selenocysteine-specific elongation factor

2

0

High-throughput

0.563

High

501234

HELD
DNA helicase IV

2

0

High-throughput

0.563

High

501237

RNR
Ribonuclease R

2

0

High-throughput

0.563

High

501238

RNE
Ribonuclease E

2

0

High-throughput

0.563

High

501240

PSS
CDP-diacylglycerol--serine O-phosphatidyltransferase PssA

2

0

High-throughput

0.563

High

501244

AIDB
Putative acyl-CoA dehydrogenase AidB

2

0

High-throughput

0.563

High

496285

CSPE
Cold shock-like protein CspE

1

1

High-throughput

0.536

High

499113

DBHB
DNA-binding protein HU-beta

1

1

High-throughput

0.536

High

494378

RS8
Small ribosomal subunit protein uS8

1

0

High-throughput

0.518

High

444346

ERA
GTPase Era

1

0

High-throughput

0.513

High

494448

RS9
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

501156

RL17
Large ribosomal subunit protein bL17

1

0

High-throughput

0.513

High

501229

RL18
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

501257

RL25
Large ribosomal subunit protein bL25

1

0

High-throughput

0.513

High

501262

NPD
NAD-dependent protein deacylase

1

0

High-throughput

0.513

High

501271

MAA
Maltose O-acetyltransferase

1

1

High-throughput

0.489

High

490967

IHFB
Integration host factor subunit beta

1

1

High-throughput

0.484

High

491744

LPXA
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

1

2

High-throughput

0.484

High

497201

FTSE
Cell division ATP-binding protein FtsE

1

1

High-throughput

0.484

High

497411

CSPC
Cold shock-like protein CspC

1

1

High-throughput

0.484

High

501236

ICLR
Transcriptional repressor IclR

1

1

High-throughput

0.484

High

501255

CLPB
Chaperone protein ClpB

1

1

High-throughput

0.484

High

501250

YHHX
Uncharacterized oxidoreductase YhhX

1

0

High-throughput

0.479

High

501261

RLMI
Ribosomal RNA large subunit methyltransferase I

1

0

High-throughput

0.479

High

501265

DCYD
D-cysteine desulfhydrase

1

0

High-throughput

0.479

High

501269

HLDE
Bifunctional protein HldE [Includes: D-beta-D-heptose 7-phosphate kinase

1

0

High-throughput

0.479

High

501247

WBBJ
Putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ

1

1

High-throughput

0.479

High

445387

BIRA
Bifunctional ligase/repressor BirA

1

0

High-throughput

0.464

High

490258

CLPP
ATP-dependent Clp protease proteolytic subunit

1

0

High-throughput

0.464

High

490887

HFQ
RNA-binding protein Hfq

1

0

High-throughput

0.464

High

491497

IF3
Translation initiation factor IF-3 [Cleaved into: Translation initiation factor IF-3, N-terminally processed; Translation initiation factor IF-3S]

1

0

High-throughput

0.464

High

491546

KDSA
2-dehydro-3-deoxyphosphooctonate aldolase

1

0

High-throughput

0.464

High

492134

HSLV
ATP-dependent protease subunit HslV

1

0

High-throughput

0.464

High

492239

PYRH
Uridylate kinase

1

0

High-throughput

0.464

High

494286

RS5
Small ribosomal subunit protein uS5

1

0

High-throughput

0.464

High

494888

TGT
Queuine tRNA-ribosyltransferase

1

0

High-throughput

0.464

High

497095

DEAD
ATP-dependent RNA helicase DeaD

1

0

High-throughput

0.464

High

497148

ACCD
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta

1

0

High-throughput

0.464

High

498339

FTSA
Cell division protein FtsA

1

0

High-throughput

0.464

High

501246

RLMN
Dual-specificity RNA methyltransferase RlmN

1

0

High-throughput

0.464

High

501253

RISB
6,7-dimethyl-8-ribityllumazine synthase

1

0

High-throughput

0.464

High

501259

GNGF
Putative gluconeogenesis factor

1

0

High-throughput

0.464

High

501266

FADI
3-ketoacyl-CoA thiolase FadI

1

0

High-throughput

0.464

High

458782

FDHF
Formate dehydrogenase H

1

0

High-throughput

0.458

High

486846

GLTD
Glutamate synthase [NADPH] small chain

1

0

High-throughput

0.458

High

490645

FABA
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase

1

0

High-throughput

0.458

High

495571

TMAR
Pole-localizer protein TmaR

1

0

High-throughput

0.458

High

501227

YFIF
Uncharacterized tRNA/rRNA methyltransferase YfiF

1

0

High-throughput

0.458

High

501254

GMHBB
D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase

1

0

High-throughput

0.458

High

501256

YDCY
Uncharacterized protein YdcY

1

0

High-throughput

0.458

High

501258

CSRA
Carbon storage regulator

1

0

High-throughput

0.458

High

501268

YFFS
Uncharacterized protein YffS

1

0

High-throughput

0.458

High

501270

MENI
1,4-dihydroxy-2-naphthoyl-CoA hydrolase

1

0

High-throughput

0.458

High

501235

SRLR
Glucitol operon repressor

1

1

High-throughput

0.442

High

491633

KPRS
Ribose-phosphate pyrophosphokinase

1

0

High-throughput

0.426

High

495236

NRDR
Transcriptional repressor NrdR

2

0

High-throughput

0.313

High

500159

DCM
DNA-cytosine methyltransferase

2

0

High-throughput

0.313

High

501242

HOLD
DNA polymerase III subunit psi

2

0

High-throughput

0.313

High

495277

YACL
UPF0231 protein YacL

2

0

High-throughput

0.307

High

497826

FTSH
ATP-dependent zinc metalloprotease FtsH

2

0

High-throughput

0.307

High

499683

FIMB
Type 1 fimbriae regulatory protein FimB

2

0

High-throughput

0.307

High

501243

MOAA
GTP 3',8-cyclase

2

0

High-throughput

0.307

High

501251

END8
Endonuclease 8

2

0

High-throughput

0.307

High

501260

YBJX
Uncharacterized protein YbjX

2

0

High-throughput

0.307

High

432419

T1SK
Type I restriction enzyme EcoKI specificity subunit

2

0

High-throughput

0.298

High

500518

INGK
Guanosine-inosine kinase

1

0

High-throughput

0.279

Low

498642

EXBB
Biopolymer transport protein ExbB

1

0

High-throughput

0.261

Low

499805

YGGE
Uncharacterized protein YggE

1

0

High-throughput

0.261

Low

501267

YFFL
Uncharacterized protein YffL

1

0

High-throughput

0.261

Low

494568

RNPA
Ribonuclease P protein component

1

0

High-throughput

0.253

Low

498909

KDTA
3-deoxy-D-manno-octulosonic acid transferase

1

0

High-throughput

0.253

Low

501230

RCSA
Transcriptional regulatory protein RcsA

1

0

High-throughput

0.253

Low

501233

TOP3
DNA topoisomerase 3

1

0

High-throughput

0.253

Low

501241

RIBD
Riboflavin biosynthesis protein RibD [Includes: Diaminohydroxyphosphoribosylaminopyrimidine deaminase

1

0

High-throughput

0.253

Low

501252

LOLA
Outer-membrane lipoprotein carrier protein

1

0

High-throughput

0.253

Low

501263

PAAX
Transcriptional repressor PaaX

1

0

High-throughput

0.253

Low

501272

YGCP
Uncharacterized protein YgcP

1

0

High-throughput

0.253

Low

501245

YADG
Uncharacterized ABC transporter ATP-binding protein YadG

1

0

High-throughput

0.249

Low

501249

YJJU
Uncharacterized protein YjjU

1

0

High-throughput

0.249

Low

501264

YNCE
Uncharacterized protein YncE

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025