Protein: PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase (1-AGP acyltransferase) (1-AGPAT) (EC 2.3.1.23) (EC 2.3.1.51) (EC 2.3.1.n7) (Lysophosphatidic acid acyltransferase) (LPAAT) (Sphingolipid compensation protein 1)

Gene: PLSC, SLC1
Organism: Saccharomyces cerevisiae S288C
Interactions: 74
UniProt ID: P33333

Gene Ontology (top 5):
GO:0003841 - 1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0005783 - endoplasmic reticulum
GO:0005811 - lipid droplet
GO:0006654 - phosphatidic acid biosynthetic process
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

751685

GCN1
eIF-2-alpha kinase activator GCN1

3

3

High-throughput

0.587

High

751699

IMB4
Importin subunit beta-4

3

5

High-throughput

0.587

High

751689

GPT2
Glycerol-3-phosphate O-acyltransferase 2

2

1

Small-scale

0.586

High

751692

FAT1
Very long-chain fatty acid transport protein

1

4

High-throughput

0.541

High

751702

AYR1
NADPH-dependent 1-acyldihydroxyacetone phosphate reductase

1

2

High-throughput

0.541

High

536000

SEC7
ADP-ribosylation factor guanine nucleotide-exchange factor SEC7

2

1

High-throughput

0.537

High

751695

ECM29
Proteasome component ECM29

2

4

High-throughput

0.537

High

528570

CP51
Lanosterol 14-alpha demethylase CYP51

1

0

High-throughput

0.518

High

571817

SNA3
Protein SNA3

1

0

High-throughput

0.518

High

702301

MGLL
Monoglyceride lipase

1

0

High-throughput

0.518

High

751686

RER2
Dehydrodolichyl diphosphate synthase complex subunit RER2

1

0

High-throughput

0.518

High

751687

KES1
Oxysterol-binding protein homolog 4

1

0

High-throughput

0.518

High

751694

ERG7
Lanosterol synthase ERG7

1

0

High-throughput

0.518

High

636294

ACO1
Acyl-CoA desaturase 1

1

1

Small-scale

0.481

High

744705

GPT1
Glycerol-3-phosphate O-acyltransferase 1

1

1

Small-scale

0.481

High

735811

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

2

Small-scale

0.479

High

751701

ELO3
Fatty acid elongase 3

1

3

High-throughput

0.479

High

751704

LCB2
Serine palmitoyltransferase 2

1

1

High-throughput

0.479

High

751711

ERV14
ER-derived vesicles protein ERV14

1

1

High-throughput

0.479

High

751720

PGA3
Plasma membrane-associated coenzyme Q6 reductase PGA3

1

2

High-throughput

0.479

High

751718

DGAT2
Diacylglycerol O-acyltransferase 1

1

0

Small-scale

0.460

High

554327

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

1

0

High-throughput

0.458

High

672143

ERG4
Delta(24(24(1)))-sterol reductase ERG4

1

0

High-throughput

0.458

High

748603

SRPR
Signal recognition particle receptor subunit alpha homolog

1

0

High-throughput

0.458

High

751684

SEC66
Translocation protein SEC66

1

0

High-throughput

0.458

High

751688

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.458

High

751693

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.458

High

751697

NSG1
Protein NSG1

1

0

High-throughput

0.458

High

751707

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

597093

BIP
Endoplasmic reticulum chaperone BiP

1

5

High-throughput

0.445

High

751696

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.445

High

579125

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.437

High

721807

XPO1
Exportin-1

1

5

High-throughput

0.437

High

734645

IMB3
Importin subunit beta-3

1

6

High-throughput

0.437

High

751690

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

751691

IMB2
Importin subunit beta-2

1

5

High-throughput

0.437

High

751714

TOM1
E3 ubiquitin-protein ligase TOM1

1

1

High-throughput

0.437

High

751715

SXM1
Importin beta SMX1

1

3

High-throughput

0.437

High

751717

IMB1
Importin subunit beta-1

1

5

High-throughput

0.437

High

450559

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.426

High

453516

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

444475

DED1
ATP-dependent RNA helicase DED1

1

1

High-throughput

0.407

High

526296

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.407

High

531676

RL4A
Large ribosomal subunit protein uL4A

1

1

High-throughput

0.407

High

544326

SSB1
Ribosome-associated molecular chaperone SSB1

1

5

High-throughput

0.407

High

740131

RPN2
26S proteasome regulatory subunit RPN2

1

2

High-throughput

0.407

High

747266

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.407

High

750917

PRS7
26S proteasome regulatory subunit 7 homolog

1

5

High-throughput

0.407

High

751710

RL4B
Large ribosomal subunit protein uL4B

1

1

High-throughput

0.407

High

605298

CAP
Adenylyl cyclase-associated protein

2

0

High-throughput

0.307

High

619412

MED14
Mediator of RNA polymerase II transcription subunit 14

2

0

High-throughput

0.307

High

751698

TCPD
T-complex protein 1 subunit delta

2

0

High-throughput

0.307

High

751706

GCN20
Protein GCN20

2

0

High-throughput

0.307

High

726899

HS104
Heat shock protein 104

2

0

High-throughput

0.305

High

751719

ENG2
Glucan endo-1,3-beta-D-glucosidase 2

1

0

High-throughput

0.282

High

575325

EI2BA
Translation initiation factor eIF2B subunit alpha

1

0

High-throughput

0.279

Low

661715

VAN1
Mannan polymerase I complex VAN1 subunit

1

0

High-throughput

0.279

Low

751716

KU80
ATP-dependent DNA helicase II subunit 2

1

0

High-throughput

0.279

Low

382868

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.249

Low

706656

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

751703

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

751708

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

751709

TOM22
Mitochondrial import receptor subunit TOM22

1

0

High-throughput

0.249

Low

751712

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.249

Low

751713

ULP1
Ubiquitin-like-specific protease 1

1

0

High-throughput

0.249

Low

365000

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.232

Low

394411

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low

403430

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

High-throughput

0.232

Low

427204

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.232

Low

432533

RL7A
Large ribosomal subunit protein uL30A

1

0

High-throughput

0.232

Low

569955

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.232

Low

689357

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.232

Low

751700

RL13B
Large ribosomal subunit protein eL13B

1

0

High-throughput

0.232

Low

751705

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025