Protein: KEX1
Pheromone-processing carboxypeptidase KEX1 (EC 3.4.16.6) (Carboxypeptidase D) (Killer expression defective protein 1)

Gene: KEX1
Organism: Saccharomyces cerevisiae S288C
Interactions: 88
UniProt ID: P09620

Gene Ontology (top 5):
GO:0000324 - fungal-type vacuole
GO:0004185 - serine-type carboxypeptidase activity
GO:0005802 - trans-Golgi network
GO:0006508 - proteolysis
GO:0006915 - apoptotic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

484255

KEX1
Pheromone-processing carboxypeptidase KEX1

1

2

High-throughput

0.698

High

484261

KEX2
Kexin

2

1

High-throughput

0.614

High

484297

ATC3
Phospholipid-transporting ATPase DRS2

2

2

High-throughput

0.614

High

484299

FLC2
Flavin carrier protein 2

2

1

High-throughput

0.613

High

484300

SHO1
High osmolarity signaling protein SHO1

2

0

High-throughput

0.587

High

484277

ATC5
Phospholipid-transporting ATPase DNF1

2

2

High-throughput

0.561

High

484265

HXT2
High-affinity glucose transporter HXT2

1

2

High-throughput

0.541

High

484272

ITR1
Myo-inositol transporter 1

1

2

High-throughput

0.541

High

484310

MUP1
High-affinity methionine permease

1

2

High-throughput

0.541

High

484333

FLC1
Flavin carrier protein 1

1

1

High-throughput

0.541

High

484337

RBD2
Rhomboid-type serine protease 2

1

2

High-throughput

0.541

High

484258

SEC7
ADP-ribosylation factor guanine nucleotide-exchange factor SEC7

1

0

High-throughput

0.518

High

484268

CDC50
Phospholipid-transporting ATPase accessory subunit CDC50

1

0

High-throughput

0.518

High

484273

VPS10
Vacuolar protein sorting/targeting protein VPS10

1

0

High-throughput

0.518

High

484285

GEF1
Anion/proton exchange transporter GEF1

1

0

High-throughput

0.518

High

484296

VATF
V-type proton ATPase subunit F

1

0

High-throughput

0.518

High

484321

DOP1
Protein DOP1

1

0

High-throughput

0.518

High

484326

DPP1
Diacylglycerol pyrophosphate phosphatase 1

1

0

High-throughput

0.518

High

484327

YL413
Cell membrane protein YLR413W

1

0

High-throughput

0.518

High

484328

OPY2
Protein OPY2

1

0

High-throughput

0.518

High

484331

BSC6
Bypass of stop codon protein 6

1

0

High-throughput

0.518

High

484335

CHS5
Chitin biosynthesis protein CHS5

1

0

High-throughput

0.518

High

484260

SSB1
Ribosome-associated molecular chaperone SSB1

2

4

High-throughput

0.504

High

484259

ARF1
ADP-ribosylation factor 1

1

1

High-throughput

0.494

High

484263

HNM1
Choline transporter

1

2

High-throughput

0.494

High

484274

HXT1
Low-affinity glucose transporter HXT1

1

2

High-throughput

0.494

High

484280

DUR3
Urea active transporter

1

1

High-throughput

0.494

High

484289

FTH1
Iron transporter FTH1

1

1

High-throughput

0.494

High

484301

FTR1
Plasma membrane iron permease

1

1

High-throughput

0.494

High

484306

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.494

High

484319

YMD8
Putative nucleotide-sugar transporter YMD8

1

1

High-throughput

0.494

High

484279

PTM1
Membrane protein PTM1

1

1

High-throughput

0.479

High

484291

YHB7
Uncharacterized membrane protein YHL071W

1

1

High-throughput

0.479

High

484309

GNP1
High-affinity glutamine permease

1

1

High-throughput

0.479

High

484311

AIM14
Probable metalloreductase AIM14

1

1

High-throughput

0.479

High

484316

TLG1
t-SNARE affecting a late Golgi compartment protein 1

1

2

High-throughput

0.479

High

484276

GDA1
Guanosine-diphosphatase

1

0

High-throughput

0.458

High

484281

NIP80
Protein NIP100

1

1

High-throughput

0.439

High

484318

ANY1
Scramblase ANY1

1

0

High-throughput

0.438

High

484267

BPH1
Beige protein homolog 1

1

1

High-throughput

0.437

High

484269

PEX3
Peroxisomal biogenesis factor 3

1

2

High-throughput

0.437

High

484270

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

484288

ATG8
Autophagy-related protein 8

1

5

High-throughput

0.437

High

484313

HST2
NAD-dependent protein deacetylase HST2

1

1

High-throughput

0.437

High

484324

TMN2
Transmembrane 9 superfamily member 2

1

1

High-throughput

0.437

High

484339

ATC4
Phospholipid-transporting ATPase DNF2

1

2

High-throughput

0.437

High

484278

TMN1
Transmembrane 9 superfamily member 1

1

1

High-throughput

0.417

High

484256

TBA1
Tubulin alpha-1 chain

1

1

High-throughput

0.407

High

484257

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.407

High

484262

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.407

High

484302

SSB2
Ribosome-associated molecular chaperone SSB2

1

4

High-throughput

0.407

High

484271

CHS3
Chitin synthase 3

3

0

High-throughput

0.343

High

484283

AUR1
Inositol phosphorylceramide synthase catalytic subunit AUR1

2

0

High-throughput

0.320

High

484284

TVP38
Golgi apparatus membrane protein TVP38

2

0

High-throughput

0.320

High

484294

AKR1
Palmitoyltransferase AKR1

2

0

High-throughput

0.320

High

484303

PEP8
Carboxypeptidase Y-deficient protein 8

2

0

High-throughput

0.319

High

484282

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

2

0

High-throughput

0.305

High

471355

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

2

0

High-throughput

0.298

High

484290

FKS1
1,3-beta-glucan synthase component FKS1

2

0

High-throughput

0.298

High

484275

SMI1
Cell wall assembly regulator SMI1

1

0

High-throughput

0.282

High

484287

SFT2
Protein transport protein SFT2

1

0

High-throughput

0.282

High

484292

CHS7
Chitin synthase export chaperone

1

0

High-throughput

0.282

High

484293

VPS45
Vacuolar protein sorting-associated protein 45

1

0

High-throughput

0.282

High

484308

COPD
Coatomer subunit delta

1

0

High-throughput

0.282

High

484314

COG6
Conserved oligomeric Golgi complex subunit 6

1

0

High-throughput

0.282

High

484320

TVP15
Golgi apparatus membrane protein TVP15

1

0

High-throughput

0.282

High

484323

PLM2
Protein PLM2

1

0

High-throughput

0.282

High

484332

SNX3
Sorting nexin-3

1

0

High-throughput

0.282

High

484334

PIN2
[PSI+] induction protein 2

1

0

High-throughput

0.282

High

484266

PUF4
Pumilio homology domain family member 4

1

0

High-throughput

0.269

Low

484329

PBP4
Protein PBP4

1

0

High-throughput

0.269

Low

484338

ISA2
Iron-sulfur assembly protein 2

1

0

High-throughput

0.269

Low

484286

VPP2
V-type proton ATPase subunit a, Golgi isoform

1

0

High-throughput

0.249

Low

484295

MNN1
Alpha-1,3-mannosyltransferase MNN1

1

0

High-throughput

0.249

Low

484298

PHO90
Low-affinity phosphate transporter PHO90

1

0

High-throughput

0.249

Low

484312

VOA1
V0 assembly protein 1

1

0

High-throughput

0.249

Low

484317

YM8V
Uncharacterized protein YMR295C

1

0

High-throughput

0.249

Low

484322

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

484325

TVP18
Golgi apparatus membrane protein TVP18

1

0

High-throughput

0.249

Low

484330

AIM6
Altered inheritance of mitochondria protein 6

1

0

High-throughput

0.249

Low

484336

MRH1
Protein MRH1

1

0

High-throughput

0.249

Low

484264

EPT1
Choline/ethanolaminephosphotransferase 1

1

0

High-throughput

0.238

Low

484305

COPB
Coatomer subunit beta

1

0

High-throughput

0.238

Low

484315

PDR12
ATP-dependent permease PDR12

1

0

High-throughput

0.238

Low

394132

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low

484304

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

0

High-throughput

0.232

Low

484307

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025