Protein: ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase (DHQS) (EC 4.2.3.4); 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS); Shikimate kinase (SK) (EC 2.7.1.71); 3-dehydroquinate dehydratase (3-dehydroquinase) (EC 4.2.1.10); Shikimate dehydrogenase (EC 1.1.1.25)]

Gene: ARO1
Organism: Saccharomyces cerevisiae S288C
Interactions: 107
UniProt ID: P08566

Gene Ontology (top 5):
GO:0003855 - 3-dehydroquinate dehydratase activity
GO:0003856 - 3-dehydroquinate synthase activity
GO:0003866 - 3-phosphoshikimate 1-carboxyvinyltransferase activity
GO:0004764 - shikimate 3-dehydrogenase (NADP+) activity
GO:0004765 - shikimate kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

471367

HSC82
ATP-dependent molecular chaperone HSC82

4

1

High-throughput

0.691

High

471451

RUVB2
RuvB-like protein 2

3

1

High-throughput

0.667

High

471371

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

2

0

High-throughput

0.602

High

471404

FHP
Flavohemoprotein

2

0

High-throughput

0.602

High

471417

TCPQ
T-complex protein 1 subunit theta

2

0

High-throughput

0.602

High

471361

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

High-throughput

0.601

High

471428

PRS8
26S proteasome regulatory subunit 8 homolog

2

1

High-throughput

0.601

High

392041

HSP82
ATP-dependent molecular chaperone HSP82

2

1

Small-scale

0.596

High

471374

RAD51
DNA repair protein RAD51

2

0

High-throughput

0.595

High

471430

RUVB1
RuvB-like protein 1

2

1

High-throughput

0.571

High

471413

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

0

High-throughput

0.559

High

471359

HSP72
Heat shock protein SSA2

2

1

High-throughput

0.552

High

471407

SSB2
Ribosome-associated molecular chaperone SSB2

2

1

High-throughput

0.552

High

471360

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.536

High

471393

PRS7
26S proteasome regulatory subunit 7 homolog

1

2

High-throughput

0.536

High

368303

TRPG
Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2

1

0

High-throughput

0.513

High

454054

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.513

High

471356

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.513

High

471396

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.513

High

471399

KSP1
Serine/threonine-protein kinase KSP1

1

0

High-throughput

0.513

High

471410

MOB1
DBF2 kinase activator protein MOB1

1

0

High-throughput

0.513

High

471412

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.513

High

471414

LSB3
LAS seventeen-binding protein 3

1

0

High-throughput

0.513

High

471427

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

High-throughput

0.513

High

471435

KU80
ATP-dependent DNA helicase II subunit 2

1

0

High-throughput

0.513

High

471450

AHA1
Hsp90 co-chaperone AHA1

1

0

High-throughput

0.513

High

471386

ARP2
Actin-related protein 2

1

1

High-throughput

0.500

High

471385

EF2
Elongation factor 2

1

2

High-throughput

0.489

High

471390

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.489

High

471415

RSSA2
Small ribosomal subunit protein uS2B

1

2

High-throughput

0.489

High

471418

LSM8
LSM2-LSM8 complex subunit LSM8

1

0

High-throughput

0.486

High

471372

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

1

0

High-throughput

0.479

High

471397

IMB2
Importin subunit beta-2

1

0

High-throughput

0.479

High

471387

HOG1
Mitogen-activated protein kinase HOG1

1

3

High-throughput

0.479

High

471426

APJ1
J domain-containing protein APJ1

1

1

High-throughput

0.479

High

471439

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

1

Small-scale

0.479

High

471442

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

1

1

High-throughput

0.470

High

471362

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

471376

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

471377

SPB4
ATP-dependent rRNA helicase SPB4

1

0

High-throughput

0.458

High

471391

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

471400

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

471408

TM108
Protein TMA108

1

0

High-throughput

0.458

High

471416

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

471419

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.458

High

471425

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

1

0

Small-scale

0.458

High

471429

ESP1
Separin

1

0

High-throughput

0.458

High

471432

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.458

High

471434

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.458

High

471440

GDE
Glycogen debranching enzyme

1

0

High-throughput

0.458

High

471441

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

471443

SGO1
Shugoshin

1

0

High-throughput

0.458

High

471444

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

471449

DBP10
ATP-dependent RNA helicase DBP10

1

0

High-throughput

0.458

High

471452

CMR1
DNA damage-binding protein CMR1

1

0

High-throughput

0.458

High

471453

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

471364

EI2BA
Translation initiation factor eIF2B subunit alpha

1

1

High-throughput

0.457

High

471358

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

471375

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.445

High

471389

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

471424

JJJ1
J protein JJJ1

1

1

High-throughput

0.445

High

471447

HSP42
Heat shock protein 42

1

2

High-throughput

0.445

High

471373

SIS1
Protein SIS1

1

1

High-throughput

0.437

High

471380

RL16A
Large ribosomal subunit protein uL13A

1

1

High-throughput

0.437

High

386526

TBB
Tubulin beta chain

1

0

High-throughput

0.426

High

394125

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

427078

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.426

High

471363

DHAS
Aspartate-semialdehyde dehydrogenase

1

0

High-throughput

0.426

High

471368

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.426

High

471369

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.426

High

471370

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.426

High

471378

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.426

High

471383

HS104
Heat shock protein 104

1

0

High-throughput

0.426

High

471406

HSP7E
Heat shock protein SSC3, mitochondrial

1

0

High-throughput

0.426

High

471409

MET18
DNA repair/transcription protein MET18/MMS19

1

0

High-throughput

0.426

High

471411

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.426

High

471421

RL4B
Large ribosomal subunit protein uL4B

1

0

High-throughput

0.426

High

471437

DYN3
Cytoplasmic dynein intermediate light chain DYN3

1

0

High-throughput

0.426

High

471388

EI2BB
Translation initiation factor eIF2B subunit beta

1

1

High-throughput

0.407

High

471365

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

2

0

High-throughput

0.328

High

471431

RPN9
26S proteasome regulatory subunit RPN9

2

0

High-throughput

0.328

High

471381

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

2

0

High-throughput

0.313

High

471405

ERP2
Protein ERP2

2

0

High-throughput

0.307

High

471355

KEX1
Pheromone-processing carboxypeptidase KEX1

2

0

High-throughput

0.298

High

471379

RFA3
Replication factor A protein 3

1

0

High-throughput

0.279

Low

471394

SPT7
SAGA complex subunit SPT7

1

0

High-throughput

0.279

Low

471398

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.279

Low

471448

SWM1
Anaphase-promoting complex subunit SWM1

1

0

High-throughput

0.279

Low

471433

UTP5
U3 small nucleolar RNA-associated protein 5

1

0

High-throughput

0.261

Low

471436

SPC24
Kinetochore protein SPC24

1

0

High-throughput

0.261

Low

381799

H4
Histone H4

1

0

High-throughput

0.249

Low

471382

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

471392

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

471395

CENPA
Histone H3-like centromeric protein CSE4

1

0

High-throughput

0.249

Low

471401

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.249

Low

471403

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

471420

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

471422

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low

471438

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

471445

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.249

Low

471446

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.249

Low

409847

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.232

Low

471357

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.232

Low

471366

SEC63
Protein translocation protein SEC63

1

0

High-throughput

0.232

Low

471384

VPS10
Vacuolar protein sorting/targeting protein VPS10

1

0

High-throughput

0.232

Low

471402

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.232

Low

471423

NOG2
Nucleolar GTP-binding protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025