Protein: COPB
Coatomer subunit beta (Beta-coat protein) (Beta-COP)

Gene: COPB, SEC26
Organism: Saccharomyces cerevisiae S288C
Interactions: 123
UniProt ID: P41810

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005198 - structural molecule activity
GO:0006886 - intracellular protein transport
GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0006890 - retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

836012

COPA
Coatomer subunit alpha

10

6

Small-scale

0.974

High

835995

COPB2
Coatomer subunit beta'

7

6

Small-scale

0.963

High

836000

COPD
Coatomer subunit delta

7

2

Small-scale

0.960

High

732160

COPG
Coatomer subunit gamma

5

18

Small-scale

0.919

High

836011

COPZ
Coatomer subunit zeta

4

20

High-throughput

0.903

High

536132

ARF1
ADP-ribosylation factor 1

2

20

Small-scale

0.768

High

801689

GLO3
ADP-ribosylation factor GTPase-activating protein GLO3

5

12

Small-scale

0.706

High

836025

ERV41
ER-derived vesicles protein ERV41

4

5

High-throughput

0.694

High

825651

COPE
Coatomer subunit epsilon

5

0

Small-scale

0.682

High

836028

VPS74
Vacuolar protein sorting-associated protein 74

2

5

Small-scale

0.602

High

795407

ATG8
Autophagy-related protein 8

2

3

High-throughput

0.584

High

652929

BET1
Protein transport protein BET1

2

2

Small-scale

0.576

High

836037

RBD2
Rhomboid-type serine protease 2

1

3

High-throughput

0.541

High

762976

SPT7
SAGA complex subunit SPT7

1

6

High-throughput

0.536

High

579578

HSC82
ATP-dependent molecular chaperone HSC82

2

2

High-throughput

0.533

High

835998

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

3

High-throughput

0.533

High

836022

TVP15
Golgi apparatus membrane protein TVP15

1

0

High-throughput

0.518

High

819012

SSB2
Ribosome-associated molecular chaperone SSB2

2

6

High-throughput

0.504

High

780082

MNN4
Mannosyltransferase regulator 4

1

9

Small-scale

0.501

High

793938

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

4

High-throughput

0.489

High

802871

DBP8
ATP-dependent RNA helicase DBP8

1

1

High-throughput

0.489

High

818009

LSM4
LSM complex subunit LSM4

1

1

High-throughput

0.489

High

825278

MOB1
DBF2 kinase activator protein MOB1

1

2

High-throughput

0.489

High

836013

BRE5
UBP3-associated protein BRE5

1

1

High-throughput

0.489

High

836021

GCN5
Histone acetyltransferase GCN5

1

9

High-throughput

0.489

High

811543

MNN1
Alpha-1,3-mannosyltransferase MNN1

1

0

Small-scale

0.480

High

836001

MNN11
Probable alpha-1,6-mannosyltransferase MNN11

1

0

Small-scale

0.480

High

836008

MST27
Multicopy suppressor of SEC21 protein 27

1

0

Small-scale

0.480

High

646249

SEC22
Protein transport protein SEC22

1

2

Small-scale

0.479

High

803081

GOSR1
Golgi SNAP receptor complex member 1

1

1

High-throughput

0.479

High

813904

ERV46
ER-derived vesicles protein ERV46

1

5

High-throughput

0.479

High

825219

SEC24
Protein transport protein SEC24

1

1

High-throughput

0.479

High

836004

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.479

High

836030

VAM6
Vacuolar morphogenesis protein 6

1

5

High-throughput

0.479

High

836039

CEX1
Cytoplasmic export protein 1

1

9

High-throughput

0.479

High

481897

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.470

High

747903

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

836014

DSL1
Protein transport protein DSL1

1

0

High-throughput

0.458

High

836041

SEC39
Protein transport protein SEC39

1

0

Small-scale

0.458

High

728648

OCH1
Initiation-specific alpha-1,6-mannosyltransferase

1

1

Small-scale

0.457

High

830054

CDC1
Cell division control protein 1

1

1

Small-scale

0.457

High

536033

SEC7
ADP-ribosylation factor guanine nucleotide-exchange factor SEC7

1

4

Small-scale

0.445

High

623878

MYO2
Myosin-2

1

1

Small-scale

0.439

High

430869

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

1

Small-scale

0.437

High

503098

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

524257

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.437

High

664443

MCM3
DNA replication licensing factor MCM3

1

5

High-throughput

0.437

High

679793

CDC48
Cell division control protein 48

1

4

High-throughput

0.437

High

682314

SPB4
ATP-dependent rRNA helicase SPB4

1

2

High-throughput

0.437

High

707371

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

744874

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

5

Small-scale

0.437

High

776595

DEF1
RNA polymerase II degradation factor 1

1

1

High-throughput

0.437

High

778378

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.437

High

779262

CENPA
Histone H3-like centromeric protein CSE4

1

1

High-throughput

0.437

High

792098

GBLP
Small ribosomal subunit protein RACK1

1

5

Small-scale

0.437

High

802225

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.437

High

803139

ECM29
Proteasome component ECM29

1

2

High-throughput

0.437

High

803586

RPN1
26S proteasome regulatory subunit RPN1

1

4

High-throughput

0.437

High

806743

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.437

High

812395

LAA1
AP-1 accessory protein LAA1

1

5

High-throughput

0.437

High

815468

RSP5
E3 ubiquitin-protein ligase RSP5

1

1

Small-scale

0.437

High

825110

AYR1
NADPH-dependent 1-acyldihydroxyacetone phosphate reductase

1

4

High-throughput

0.437

High

835997

LAM5
Membrane-anchored lipid-binding protein LAM5

1

3

High-throughput

0.437

High

835999

ATG18
Autophagy-related protein 18

1

2

High-throughput

0.437

High

836006

ATG1
Serine/threonine-protein kinase ATG1

1

1

High-throughput

0.437

High

836009

CDH1
APC/C activator protein CDH1

1

8

Small-scale

0.437

High

836010

PESC
Pescadillo homolog

1

1

High-throughput

0.437

High

836017

NUM1
Nuclear migration protein NUM1

1

2

High-throughput

0.437

High

836019

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.437

High

836024

RUVB1
RuvB-like protein 1

1

3

High-throughput

0.437

High

836033

ESA1
Histone acetyltransferase ESA1

1

1

Small-scale

0.437

High

836038

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.437

High

836040

RUVB2
RuvB-like protein 2

1

3

High-throughput

0.437

High

836042

SMC6
Structural maintenance of chromosomes protein 6

1

2

High-throughput

0.437

High

836016

TMEDA
Endoplasmic reticulum vesicle protein 25

1

7

Small-scale

0.408

High

575961

CYPH
Peptidyl-prolyl cis-trans isomerase

1

2

High-throughput

0.407

High

750962

PRS7
26S proteasome regulatory subunit 7 homolog

1

8

High-throughput

0.407

High

836023

WDR59
Maintenance of telomere capping protein 5

1

9

High-throughput

0.407

High

783989

RM10
Large ribosomal subunit protein uL15m

2

0

High-throughput

0.324

High

797481

TOS1
Probable circularly permuted 1,3-beta-glucanase TOS1

2

0

High-throughput

0.307

High

571840

SNA3
Protein SNA3

1

0

High-throughput

0.282

High

728706

ACBP
Acyl-CoA-binding protein

1

0

High-throughput

0.282

High

740272

SMI1
Cell wall assembly regulator SMI1

1

0

High-throughput

0.282

High

751031

SUR1
Mannosyl phosphorylinositol ceramide synthase SUR1

1

0

High-throughput

0.282

High

781300

AUR1
Inositol phosphorylceramide synthase catalytic subunit AUR1

1

0

High-throughput

0.282

High

792838

ANM1
Protein arginine N-methyltransferase 1

1

0

Small-scale

0.282

High

835996

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.282

High

836018

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

High-throughput

0.279

Low

836032

MCA1
Metacaspase-1

1

0

Small-scale

0.279

Low

796264

FMP23
Protein FMP23, mitochondrial

1

0

High-throughput

0.269

Low

836005

PIP2
Peroxisome proliferation transcriptional regulator

1

0

High-throughput

0.269

Low

836035

FCF2
rRNA-processing protein FCF2

1

0

High-throughput

0.269

Low

794044

KTR3
Probable mannosyltransferase KTR3

1

0

Small-scale

0.261

Low

383750

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

433695

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

435158

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.249

Low

649635

KCC2
Calcium/calmodulin-dependent protein kinase II

1

0

High-throughput

0.249

Low

670832

SIS1
Protein SIS1

1

0

High-throughput

0.249

Low

727108

HS104
Heat shock protein 104

1

0

High-throughput

0.249

Low

735344

ERG3
Delta(7)-sterol 5(6)-desaturase ERG3

1

0

High-throughput

0.249

Low

753426

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

782216

GPT2
Glycerol-3-phosphate O-acyltransferase 2

1

0

High-throughput

0.249

Low

797181

ATG14
Autophagy-related protein 14

1

0

High-throughput

0.249

Low

804810

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

0

High-throughput

0.249

Low

812280

ATC3
Phospholipid-transporting ATPase DRS2

1

0

Small-scale

0.249

Low

826577

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

836002

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

836003

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

836015

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.249

Low

836020

ESP1
Separin

1

0

High-throughput

0.249

Low

836026

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

836027

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

836029

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.249

Low

836031

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

836034

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

836036

LSP1
Sphingolipid long chain base-responsive protein LSP1

1

0

Small-scale

0.249

Low

484305

KEX1
Pheromone-processing carboxypeptidase KEX1

1

0

High-throughput

0.238

Low

797846

FTH1
Iron transporter FTH1

1

0

High-throughput

0.238

Low

597741

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.232

Low

737358

DPH5
Diphthine methyl ester synthase

1

0

High-throughput

0.232

Low

794710

SEA4
SEH-associated protein 4

1

0

High-throughput

0.232

Low

807232

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.232

Low

836007

RRT6
Regulator of rDNA transcription protein 6

1

0

Small-scale

0.213

Low


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Last updated: 11Aug2025