Protein: SAS10
Something about silencing protein 10 (U three protein 3) (U3 small nucleolar RNA-associated protein 3) (U3 snoRNA-associated protein 11)

Gene: SAS10
Organism: Saccharomyces cerevisiae S288C
Interactions: 200
UniProt ID: Q12136

Gene Ontology (top 5):
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1084350

RRP6
Exosome complex exonuclease RRP6

2

1

High-throughput

0.754

High

825575

UTP25
U3 small nucleolar RNA-associated protein 25

5

1

Small-scale

0.729

High

865191

MPP10
U3 small nucleolar RNA-associated protein MPP10

5

1

Small-scale

0.723

High

1053534

UTP21
U3 small nucleolar RNA-associated protein 21

4

2

Small-scale

0.691

High

1046084

DHR1
Probable ATP-dependent RNA helicase DHR1

5

0

Small-scale

0.680

High

1055518

NOC4
Nucleolar complex protein 4

5

0

Small-scale

0.680

High

677613

KRR1
KRR1 small subunit processome component

3

1

High-throughput

0.672

High

798349

ENP1
Essential nuclear protein 1

4

0

High-throughput

0.659

High

844658

UTP10
U3 small nucleolar RNA-associated protein 10

4

0

High-throughput

0.659

High

1036429

UTP6
U3 small nucleolar RNA-associated protein 6

3

0

Small-scale

0.649

High

1084360

NOP58
Nucleolar protein 58

3

2

Small-scale

0.640

High

632762

DBP4
ATP-dependent RNA helicase HCA4

2

2

High-throughput

0.637

High

747062

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

2

2

High-throughput

0.637

High

1046823

UTP14
U3 small nucleolar RNA-associated protein 14

3

0

High-throughput

0.630

High

1084349

SAS10
Something about silencing protein 10

2

0

Small-scale

0.619

High

678482

PWP2
Periodic tryptophan protein 2

2

2

High-throughput

0.614

High

802921

DBP8
ATP-dependent RNA helicase DBP8

2

1

High-throughput

0.614

High

817654

UTP7
U3 small nucleolar RNA-associated protein 7

2

3

High-throughput

0.614

High

1084359

RRP36
rRNA biogenesis protein RRP36

2

0

High-throughput

0.610

High

1084365

NOP14
Nucleolar complex protein 14

2

0

High-throughput

0.610

High

917506

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

2

1

High-throughput

0.608

High

758425

UTP11
U3 small nucleolar RNA-associated protein 11

2

0

High-throughput

0.588

High

823408

UTP18
U3 small nucleolar RNA-associated protein 18

2

0

High-throughput

0.588

High

852625

ROK1
ATP-dependent RNA helicase ROK1

2

0

High-throughput

0.588

High

918855

UTP22
U3 small nucleolar RNA-associated protein 22

2

0

High-throughput

0.588

High

1054908

ESF1
Pre-rRNA-processing protein ESF1

2

0

High-throughput

0.588

High

1084361

SKS1
Serine/threonine-protein kinase SKS1

2

1

High-throughput

0.586

High

826228

FAF1
Protein FAF1

2

0

Small-scale

0.585

High

1056496

UTP4
U3 small nucleolar RNA-associated protein 4

2

3

Small-scale

0.584

High

1043313

HAS1
ATP-dependent RNA helicase HAS1

1

2

High-throughput

0.582

High

364804

CDK1
Cyclin-dependent kinase 1

2

0

High-throughput

0.569

High

672978

RRP43
Exosome complex component RRP43

2

0

High-throughput

0.559

High

826923

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.559

High

923999

CSL4
Exosome complex component CSL4

2

0

High-throughput

0.559

High

919600

NOP19
Nucleolar protein 19

1

0

High-throughput

0.558

High

779170

DHR2
Probable ATP-dependent RNA helicase DHR2

1

2

High-throughput

0.541

High

802779

RRP3
ATP-dependent rRNA helicase RRP3

1

2

High-throughput

0.541

High

503298

RS22A
Small ribosomal subunit protein uS8A

2

1

High-throughput

0.533

High

794312

DUG2
Probable di- and tripeptidase DUG2

1

0

High-throughput

0.518

High

864983

NOP9
Nucleolar protein 9

1

0

High-throughput

0.518

High

918619

SLX9
Ribosome biogenesis protein SLX9

1

0

High-throughput

0.518

High

924138

SQS1
Protein SQS1

1

0

High-throughput

0.518

High

1053789

SGD1
Suppressor of glycerol defect protein 1

1

0

High-throughput

0.518

High

627877

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

1

1

High-throughput

0.515

High

657013

BUR1
Serine/threonine-protein kinase BUR1

1

1

High-throughput

0.515

High

709487

HRR25
Casein kinase I homolog HRR25

1

0

High-throughput

0.513

High

722349

XPO1
Exportin-1

1

0

High-throughput

0.513

High

782487

RPF2
Ribosome biogenesis protein RPF2

1

0

High-throughput

0.513

High

441294

KAPA
cAMP-dependent protein kinase type 1

1

1

High-throughput

0.501

High

574751

KSS1
Mitogen-activated protein kinase KSS1

1

1

High-throughput

0.501

High

599418

FUS3
Mitogen-activated protein kinase FUS3

1

1

High-throughput

0.501

High

645988

DBF2
Cell cycle protein kinase DBF2

1

2

High-throughput

0.501

High

656668

KC11
Casein kinase I homolog 1

1

2

High-throughput

0.501

High

656909

KC12
Casein kinase I homolog 2

1

2

High-throughput

0.501

High

672208

KIN82
Serine/threonine-protein kinase KIN82

1

1

High-throughput

0.501

High

735581

IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

1

High-throughput

0.501

High

740627

IME2
Meiosis induction protein kinase IME2/SME1

1

2

High-throughput

0.501

High

800778

RCK1
Serine/threonine-protein kinase RCK1

1

1

High-throughput

0.501

High

801954

KSP1
Serine/threonine-protein kinase KSP1

1

2

High-throughput

0.501

High

874272

CLA4
Serine/threonine-protein kinase CLA4

1

2

High-throughput

0.501

High

1043012

STE20
Serine/threonine-protein kinase STE20

1

2

High-throughput

0.501

High

1084352

GIN4
Serine/threonine-protein kinase GIN4

1

1

High-throughput

0.501

High

1084358

SKM1
Serine/threonine-protein kinase SKM1

1

2

High-throughput

0.501

High

866144

JHD2
Histone demethylase JHD2

1

0

High-throughput

0.493

High

642491

MCK1
Protein kinase MCK1

1

0

High-throughput

0.480

High

646564

RAD53
Serine/threonine-protein kinase RAD53

1

0

High-throughput

0.480

High

725944

PSK1
Serine/threonine-protein kinase PSK1

1

0

High-throughput

0.480

High

778924

NNK1
Nitrogen network kinase 1

1

0

High-throughput

0.480

High

150007

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.479

High

512710

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

513279

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.479

High

645010

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

1

High-throughput

0.479

High

647246

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.479

High

674889

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

708498

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

708801

TF3B
Transcription factor IIIB 70 kDa subunit

1

1

High-throughput

0.479

High

747631

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.479

High

754353

DCA13
Protein SOF1

1

1

High-throughput

0.479

High

782119

RL1D1
Ribosome biogenesis protein UTP30

1

1

High-throughput

0.479

High

792306

GBLP
Small ribosomal subunit protein RACK1

1

1

Small-scale

0.479

High

824808

MLP2
Protein MLP2

1

1

High-throughput

0.479

High

863151

RRP41
Exosome complex component SKI6

1

3

High-throughput

0.479

High

864551

MTR4
ATP-dependent RNA helicase DOB1

1

1

High-throughput

0.479

High

918910

RRP46
Exosome complex component RRP46

1

3

High-throughput

0.479

High

923268

ESF2
Pre-rRNA-processing protein ESF2

1

1

High-throughput

0.479

High

925217

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

1

High-throughput

0.479

High

1039874

UTP17
NET1-associated nuclear protein 1

1

3

High-throughput

0.479

High

1045124

UTP5
U3 small nucleolar RNA-associated protein 5

1

2

High-throughput

0.479

High

1046274

UTP15
U3 small nucleolar RNA-associated protein 15

1

1

High-throughput

0.479

High

1050204

RRP5
rRNA biogenesis protein RRP5

1

1

High-throughput

0.479

High

1051725

RRP45
Exosome complex component RRP45

1

3

High-throughput

0.479

High

1053132

UTP13
U3 small nucleolar RNA-associated protein 13

1

3

High-throughput

0.479

High

1055445

RRP9
Ribosomal RNA-processing protein 9

1

1

High-throughput

0.479

High

1061957

RRP44
Exosome complex exonuclease DIS3

1

1

High-throughput

0.479

High

1064652

ESA1
Histone acetyltransferase ESA1

1

1

Small-scale

0.479

High

1084351

UTP12
U3 small nucleolar RNA-associated protein 12

1

2

High-throughput

0.479

High

1084353

RRP42
Exosome complex component RRP42

1

3

High-throughput

0.479

High

1084357

NOP56
Nucleolar protein 56

1

2

High-throughput

0.479

High

548735

RNA1
Ran GTPase-activating protein 1

1

0

High-throughput

0.460

High

755314

NUF2
Kinetochore protein NUF2

1

0

High-throughput

0.460

High

828519

SA185
SIT4-associating protein SAP185

1

0

High-throughput

0.460

High

830210

NOP2
25S rRNA

1

0

High-throughput

0.460

High

1046724

SPC24
Kinetochore protein SPC24

1

0

High-throughput

0.460

High

435429

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

436226

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

436548

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

0

High-throughput

0.458

High

442165

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

514884

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

671233

SIS1
Protein SIS1

1

0

High-throughput

0.458

High

673249

RRP7
Ribosomal RNA-processing protein 7

1

0

High-throughput

0.458

High

689718

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

735221

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

753647

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

763649

UTP20
U3 small nucleolar RNA-associated protein 20

1

0

High-throughput

0.458

High

778586

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

802442

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

804765

RRP4
Exosome complex component RRP4

1

0

High-throughput

0.458

High

804973

LRP1
Exosome complex protein LRP1

1

0

High-throughput

0.458

High

806596

UTP9
U3 small nucleolar RNA-associated protein 9

1

0

High-throughput

0.458

High

808327

RRP8
25S rRNA

1

0

High-throughput

0.458

High

818360

LCP5
U3 small nucleolar ribonucleoprotein protein LCP5

1

0

High-throughput

0.458

High

825097

RRT14
Regulator of rDNA transcription protein 14

1

0

High-throughput

0.458

High

826109

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.458

High

836215

DIM1
Dimethyladenosine transferase

1

0

Small-scale

0.458

High

871075

NOL10
Ribosome biogenesis protein ENP2

1

0

High-throughput

0.458

High

871140

MTR3
Exosome complex component MTR3

1

0

High-throughput

0.458

High

874585

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

919043

PESC
Pescadillo homolog

1

0

High-throughput

0.458

High

919193

UTP8
U3 small nucleolar RNA-associated protein 8

1

0

High-throughput

0.458

High

924660

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.458

High

925127

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

932248

ORC1
Origin recognition complex subunit 1

1

0

High-throughput

0.458

High

1051174

FCF1
rRNA-processing protein FCF1

1

0

High-throughput

0.458

High

1054554

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.458

High

1054869

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

1056326

BFR2
Protein BFR2

1

0

High-throughput

0.458

High

1060762

CMS1
Protein CMS1

1

0

High-throughput

0.458

High

1061644

RCL1
rRNA processing protein RCL1

1

0

High-throughput

0.458

High

1062918

RRP40
Exosome complex component RRP40

1

0

High-throughput

0.458

High

1064284

SGO1
Shugoshin

1

0

High-throughput

0.458

High

1064328

UTP16
U3 small nucleolar RNA-associated protein 16

1

0

High-throughput

0.458

High

1065597

BMS1
Ribosome biogenesis protein BMS1

1

0

High-throughput

0.458

High

1084160

FCF2
rRNA-processing protein FCF2

1

0

High-throughput

0.458

High

1084355

DBP10
ATP-dependent RNA helicase DBP10

1

0

High-throughput

0.458

High

1084363

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.458

High

1084366

PNO1
Pre-rRNA-processing protein PNO1

1

0

High-throughput

0.458

High

918406

FMP48
Probable serine/threonine-protein kinase FMP48

1

3

High-throughput

0.457

High

1064751

HRK1
Serine/threonine-protein kinase HRK1

1

1

High-throughput

0.457

High

1084354

PRR2
Serine/threonine-protein kinase PRR2

1

2

High-throughput

0.457

High

550088

RAP1
DNA-binding protein RAP1

1

0

High-throughput

0.438

High

724324

PUS3
tRNA pseudouridine(38/39) synthase

1

0

High-throughput

0.438

High

740535

SIP1
SNF1 protein kinase subunit beta-1

1

0

High-throughput

0.438

High

864347

NET1
Nucleolar protein NET1

1

0

High-throughput

0.438

High

916845

RMR1
Reduced meiotic recombination protein 1

1

0

High-throughput

0.438

High

1064683

TMA16
Translation machinery-associated protein 16

1

0

High-throughput

0.438

High

1084338

MED2
Mediator of RNA polymerase II transcription subunit 2

1

0

High-throughput

0.438

High

410389

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

455313

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.437

High

504469

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

1064821

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.437

High

1084364

RS22B
Small ribosomal subunit protein uS8B

1

1

High-throughput

0.437

High

525502

HSP71
Heat shock protein SSA1

1

0

High-throughput

0.426

High

727393

HS104
Heat shock protein 104

1

0

High-throughput

0.426

High

866319

PMT3
Dolichyl-phosphate-mannose--protein mannosyltransferase 3

1

1

High-throughput

0.417

High

1056372

PMT7
Probable dolichyl-phosphate-mannose--protein mannosyltransferase 7

1

1

High-throughput

0.417

High

737166

ERG24
Delta(14)-sterol reductase ERG24

1

0

High-throughput

0.282

High

796239

FAT1
Very long-chain fatty acid transport protein

1

0

High-throughput

0.282

High

746316

UGPA1
UTP--glucose-1-phosphate uridylyltransferase

1

0

High-throughput

0.269

Low

825438

PRK1
Actin-regulating kinase PRK1

1

0

High-throughput

0.261

Low

917208

ATG1
Serine/threonine-protein kinase ATG1

1

0

High-throughput

0.261

Low

1033869

KIN4
Serine/threonine-protein kinase KIN4

1

0

High-throughput

0.261

Low

383942

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

432733

RL7A
Large ribosomal subunit protein uL30A

1

0

High-throughput

0.249

Low

433898

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

477649

MYO1
Myosin-1

1

0

Small-scale

0.249

Low

558900

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

812759

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

918492

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.249

Low

1025064

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.249

Low

1033626

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

1046327

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.249

Low

564789

ATN1
Sodium/potassium exporting P-type ATPase 1

1

0

High-throughput

0.238

Low

678057

HSP30
30 kDa heat shock protein

1

0

High-throughput

0.238

Low

763703

GCS1
ADP-ribosylation factor GTPase-activating protein GCS1

1

0

High-throughput

0.238

Low

863286

GPI2
Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit

1

0

High-throughput

0.238

Low

863905

YJR5
Putative uncharacterized membrane protein YJL175W

1

0

High-throughput

0.238

Low

865656

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.238

Low

917090

YIP4
Protein YIP4

1

0

High-throughput

0.238

Low

917119

YGT5
Putative 2-hydroxyacid dehydrogenase YGL185C

1

0

High-throughput

0.238

Low

919339

YG3R
Putative uncharacterized protein YGR160W

1

0

High-throughput

0.238

Low

919810

YG61
Putative uncharacterized membrane protein YGR290W

1

0

High-throughput

0.238

Low

924690

ESBP6
Uncharacterized transporter ESBP6

1

0

High-throughput

0.238

Low

1018186

YD269
Putative uncharacterized protein YDR269C

1

0

High-throughput

0.238

Low

1058761

SSK1
Osmolarity two-component system protein SSK1

1

0

High-throughput

0.238

Low

1062873

YOL18
Uncharacterized protein YOL118C

1

0

High-throughput

0.238

Low

1084138

AP1G1
AP-1 complex subunit gamma-1

1

0

High-throughput

0.238

Low

1084356

YO309
Putative uncharacterized protein YOR309C

1

0

High-throughput

0.238

Low

1084362

YO314
Uncharacterized protein YOR314W

1

0

High-throughput

0.238

Low

811066

TCPD
T-complex protein 1 subunit delta

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025