Protein: IL12A
Interleukin-12 subunit alpha (IL-12A) (Cytotoxic lymphocyte maturation factor 35 kDa subunit) (CLMF p35) (IL-12 subunit p35) (NK cell stimulatory factor chain 1) (NKSF1)

Gene: IL12A
Organism: Homo sapiens
Interactions: 31
UniProt ID: P29459

Gene Ontology (top 5):
GO:0001916 - positive regulation of T cell mediated cytotoxicity
GO:0002860 - positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0005125 - cytokine activity
GO:0005143 - interleukin-12 receptor binding
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

712716

IL12B
Interleukin-12 subunit beta

4

3

Small-scale

0.890

High

712724

IRF8
Interferon regulatory factor 8

3

7

Small-scale

0.640

High

712725

TF65
Transcription factor p65

3

4

Small-scale

0.640

High

712719

I12R1
Interleukin-12 receptor subunit beta-1

2

1

Small-scale

0.624

High

533885

IRF1
Interferon regulatory factor 1

4

7

Small-scale

0.617

High

712737

I12R2
Interleukin-12 receptor subunit beta-2

1

0

Small-scale

0.614

High

712727

COEA1
Collagen alpha-1(XIV) chain

2

0

High-throughput

0.602

High

712728

FSTL1
Follistatin-related protein 1

2

0

High-throughput

0.602

High

712735

SPDLY
Protein Spindly

2

0

High-throughput

0.602

High

712726

REL
Proto-oncogene c-Rel

3

4

Small-scale

0.585

High

712729

IRF5
Interferon regulatory factor 5

2

7

Small-scale

0.584

High

712730

IL27B
Interleukin-27 subunit beta

2

3

Small-scale

0.584

High

712731

IRF3
Interferon regulatory factor 3

2

7

Small-scale

0.584

High

712722

ACTA
Actin, aortic smooth muscle

1

0

High-throughput

0.513

High

445132

S10A6
Protein S100-A6

1

1

Small-scale

0.501

High

682448

S100P
Protein S100-P

1

1

Small-scale

0.501

High

626085

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

4

Small-scale

0.479

High

712734

IRF7
Interferon regulatory factor 7

1

7

Small-scale

0.479

High

712718

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

1

Small-scale

0.437

High

712721

STAT2
Signal transducer and activator of transcription 2

1

1

Small-scale

0.437

High

712723

IRF9
Interferon regulatory factor 9

1

7

Small-scale

0.437

High

712732

IRF4
Interferon regulatory factor 4

1

7

Small-scale

0.437

High

683714

PTX3
Pentraxin-related protein PTX3

1

0

High-throughput

0.426

High

712720

MAPK2
MAP kinase-activated protein kinase 2

1

0

High-throughput

0.426

High

712739

JAM1
Junctional adhesion molecule A

2

0

High-throughput

0.328

High

630460

RAB3B
Ras-related protein Rab-3B

1

0

High-throughput

0.279

Low

464830

SP1
Transcription factor Sp1

1

0

Small-scale

0.249

Low

712717

ETFB
Electron transfer flavoprotein subunit beta

1

0

High-throughput

0.232

Low

712733

XXLT1
Xyloside xylosyltransferase 1

1

0

High-throughput

0.232

Low

712736

MIA2
Melanoma inhibitory activity protein 2

1

0

High-throughput

0.232

Low

712738

TLRN1
Talin rod domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025