HitPredict

Interactor 1: COF1 (P23528)
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)
Gene: CFL1

Interactor 2: ACTA (P62736)
Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form]
Gene: ACTA2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Cofilin_ADF
Common GO terms	GO:0005615 - extracellular space GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0009615 - response to virus GO:0030027 - lamellipodium and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 166 Hs			1 377
+	Hs
		618104 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		ACTBL_HUMAN (4-377): 0: 712: 87.97
+	Mm
		578583 COF1_MOUSE (1-166): 1.35e-72: 217: 98.80		ACTB_MOUSE (4-377): 0: 598: 94.12
+	Rn
		799735 COF1_RAT (1-166): 3.11e-72: 216: 99.40		ACTB_RAT (4-377): 0: 598: 94.12
+	Hs
		618038 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		618049 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		ACTG_HUMAN (4-377): 0: 598: 94.39
+	Hs
		618052 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		ACTC_HUMAN (1-377): 0: 598: 98.41
+	Hs
		618053 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		ACTS_HUMAN (1-377): 0: 598: 97.88
+	Hs
		618096 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		Q1KLZ0_HUMAN (4-377): 0: 598: 94.12
+	Hs
		1092828 Q549N0_HUMAN (1-166): 1.68e-71: 214: 80.72		Q1KLZ0_HUMAN (4-377): 0: 598: 94.12
+	Hs
		891817 Q549N0_HUMAN (1-166): 1.68e-71: 214: 80.72		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		892124 COF2_HUMAN (1-166): 1.68e-71: 214: 80.72		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		929891 Q549N0_HUMAN (1-166): 1.68e-71: 214: 80.72		ACTG_HUMAN (4-377): 0: 598: 94.39
+	Hs
		930059 COF2_HUMAN (1-166): 1.68e-71: 214: 80.72		ACTG_HUMAN (4-377): 0: 598: 94.39
+	Hs
		932464 COF2_HUMAN (1-166): 1.68e-71: 214: 80.72		ACTC_HUMAN (1-377): 0: 598: 98.41
+	Hs
		618050 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		ACTH_HUMAN (4-377): 0: 591: 99.20
+	Hs
		891649 DEST_HUMAN (1-166): 3.71e-69: 208: 71.08		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		894652 DEST_HUMAN (1-166): 3.71e-69: 208: 71.08		ACTG_HUMAN (4-377): 0: 598: 94.39
+	Hs
		894665 DEST_HUMAN (1-166): 3.71e-69: 208: 71.08		Q1KLZ0_HUMAN (4-377): 0: 598: 94.12
+	Hs
		894651 DEST_HUMAN (1-166): 3.71e-69: 208: 71.08		ACTA_HUMAN (1-377): 0: 596: 100.00
+	At
		477715 ADF4_ARATH (2-146): 7.32e-49: 156: 34.93		ACT1_ARATH (1-377): 0: 591: 87.80