HitPredict

Interactor 1: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Interactor 2: ARHGI (Q6ZSZ5)
Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor) (p114-Rho-GEF) (p114RhoGEF) (Septin-associated RhoGEF) (SA-RhoGEF)
Gene: ARHGEF18

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 31871319
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH_16~Ras, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 196 Hs			1 1361
+	Sp
		1439782 RHO5_SCHPO (4-181): 2.58e-87: 256: 67.98		RGF1_SCHPO (43-996): 1.67e-81: 296: 12.97
+	Hs
		988587 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		ARHG2_HUMAN (258-1247): 7.76e-90: 316: 30.17
+	Hs
		177376 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		ARHGB_HUMAN (251-1002): 1.77e-86: 312: 17.81
+	Sp
		1068728 RHO1_SCHPO (1-194): 8e-82: 243: 68.21		RGF1_SCHPO (43-996): 1.67e-81: 296: 12.97
+	Hs
		584511 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		VAV_HUMAN (374-820): 4.05e-79: 281: 17.66
+	Mm
		694458 RHOA_MOUSE (1-196): 1.77e-78: 234: 83.16		RGRF1_MOUSE (189-1028): 2.46e-76: 279: 12.21
+	Hs
		988820 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		PKHG1_HUMAN (397-1150): 1.13e-74: 275: 12.91
+	Hs
		988358 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		ARHG7_HUMAN (233-996): 3.37e-76: 272: 12.58
+	Hs
		988741 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		ARHG4_HUMAN (167-873): 3.02e-77: 272: 11.99
+	Hs
		988472 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		PREX2_HUMAN (426-890): 6e-73: 270: 14.52
+	Sp
		1068727 RHO1_SCHPO (1-194): 8e-82: 243: 68.21		RGF3_SCHPO (429-762): 8.38e-70: 259: 22.73
+	Hs
		988618 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		SPT13_HUMAN (225-863): 2.81e-75: 266: 11.60
+	Hs
		165458 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		RGRF2_HUMAN (210-1010): 3.22e-71: 264: 11.53
+	Hs
		988376 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		ARHG6_HUMAN (300-1036): 1.02e-73: 264: 13.03
+	Hs
		988545 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		PREX1_HUMAN (405-1221): 1.69e-69: 259: 11.80
+	Hs
		913637 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		VAV2_HUMAN (361-820): 6.75e-69: 252: 15.45
+	Hs
		238812 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		KALRN_HUMAN (60-1039): 9.97e-57: 219: 11.61
+	Sc
		448555 RHO1_YEAST (3-186): 1.42e-88: 260: 67.39		ROM2_YEAST (420-718): 1.52e-39: 163: 21.87
+	Sp
		1068725 RHO1_SCHPO (1-194): 8e-82: 243: 68.21		RGF2_SCHPO (360-720): 1.27e-44: 178: 17.46
+	Mm
		1226826 RHOA_MOUSE (1-196): 1.77e-78: 234: 83.16		PKHG5_MOUSE (427-924): 1.65e-39: 162: 19.13