HitPredict

Interactor 1: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Interactor 2: NGEF (Q8N5V2)
Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor)
Gene: NGEF

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	19637314
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~RhoGEF, Ras~SOS1_NGEF_PH
Common GO terms	GO:0005829 - cytosol GO:0030154 - cell differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 196 Hs			1 710
+	Hs
		988526 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		NGEF_HUMAN (1-710): 0: 541: 100.00
+	Hs
		988602 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		ARHGQ_HUMAN (11-691): 1.09e-118: 378: 26.84
+	Hs
		988506 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		ARHGJ_HUMAN (1-691): 8.73e-112: 358: 32.01
+	Hs
		988618 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		SPT13_HUMAN (13-630): 5.2e-107: 341: 14.56
+	Hs
		988741 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		ARHG4_HUMAN (9-644): 4.43e-103: 332: 15.36
+	Hs
		584511 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		VAV_HUMAN (180-709): 7.81e-97: 319: 15.14
+	Hs
		988811 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		VAV3_HUMAN (180-708): 3.17e-96: 318: 12.45
+	Hs
		177376 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		ARHGB_HUMAN (3-708): 8.91e-90: 309: 15.70
+	Hs
		177373 RHOA_HUMAN (1-196): 4.38e-78: 233: 83.67		ARHGB_HUMAN (3-708): 8.91e-90: 309: 15.70
+	Mm
		694458 RHOA_MOUSE (1-196): 1.77e-78: 234: 83.16		RGRF1_MOUSE (76-638): 3.28e-88: 303: 15.78
+	Hs
		913637 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		VAV2_HUMAN (167-682): 6.59e-90: 301: 13.91
+	Hs
		988472 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		PREX2_HUMAN (251-614): 5.3e-86: 298: 19.48
+	Hs
		988545 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		PREX1_HUMAN (223-613): 2.53e-85: 296: 19.66
+	Hs
		988716 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		ECT2_HUMAN (147-681): 3.8e-87: 294: 15.72
+	Hs
		988587 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		ARHG2_HUMAN (103-694): 2.94e-85: 291: 13.89
+	Hs
		165458 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		RGRF2_HUMAN (76-598): 1.34e-83: 289: 15.66
+	Hs
		165456 RHOA_HUMAN (1-196): 4.38e-78: 233: 83.67		RGRF2_HUMAN (76-598): 1.34e-83: 289: 15.66
+	Hs
		299534 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		TRIO_HUMAN (256-658): 9.09e-58: 215: 19.29
+	Hs
		238812 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		KALRN_HUMAN (262-672): 6.99e-55: 206: 18.87
+	Sp
		1068727 RHO1_SCHPO (1-194): 8e-82: 243: 68.21		RGF3_SCHPO (271-530): 5.69e-11: 68.2: 25.46