Protein: FL2D
Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (hFL(2)D) (WT1-associated protein) (Wilms tumor 1-associating protein)

Gene: FL2D, WTAP
Organism: Homo sapiens
Interactions: 208
UniProt ID: Q15007

Gene Ontology (top 5):
GO:0000381 - regulation of alternative mRNA splicing, via spliceosome
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0006397 - mRNA processing

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1136431

FL2D
Pre-mRNA-splicing regulator WTAP

3

1

High-throughput

0.843

High

1136460

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

6

4

Small-scale

0.731

High

1104579

IKZF1
DNA-binding protein Ikaros

6

0

High-throughput

0.707

High

624504

WT1
Wilms tumor protein

4

0

Small-scale

0.670

High

1136452

ABRX1
BRCA1-A complex subunit Abraxas 1

3

1

High-throughput

0.667

High

1136468

CBLL2
E3 ubiquitin-protein ligase CBLL2

3

1

High-throughput

0.667

High

1136493

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

3

1

High-throughput

0.665

High

848868

MAGAB
Melanoma-associated antigen 11

3

0

High-throughput

0.639

High

1136497

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

2

4

Small-scale

0.618

High

990240

1433Z
14-3-3 protein zeta/delta

2

3

High-throughput

0.611

High

995601

ACTC
Actin, alpha cardiac muscle 1

2

1

High-throughput

0.611

High

1118025

DX39B
Spliceosome RNA helicase DDX39B

2

2

High-throughput

0.611

High

1136447

VIR
Protein virilizer homolog

2

1

High-throughput

0.611

High

680876

PSA1
Proteasome subunit alpha type-1

2

2

High-throughput

0.606

High

1136485

HTF4
Transcription factor 12

2

1

High-throughput

0.606

High

1136457

3BP5L
SH3 domain-binding protein 5-like

2

0

High-throughput

0.602

High

537185

HSP7C
Heat shock cognate 71 kDa protein

2

0

High-throughput

0.585

High

979679

H4
Histone H4

2

0

High-throughput

0.585

High

1118859

BYST
Bystin

2

0

High-throughput

0.580

High

1136432

TNIP1
TNFAIP3-interacting protein 1

2

0

High-throughput

0.580

High

1136435

ZN239
Zinc finger protein 239

2

0

High-throughput

0.580

High

1136458

ZN572
Zinc finger protein 572

2

0

High-throughput

0.580

High

1136461

ZCH18
Zinc finger CCCH domain-containing protein 18

2

0

High-throughput

0.547

High

123102

DX39A
ATP-dependent RNA helicase DDX39A

1

2

High-throughput

0.536

High

272659

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

1

High-throughput

0.536

High

385108

K1C14
Keratin, type I cytoskeletal 14

1

8

High-throughput

0.536

High

385275

K2C6A
Keratin, type II cytoskeletal 6A

1

6

High-throughput

0.536

High

385753

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

6

High-throughput

0.536

High

402935

ANXA1
Annexin A1

1

1

High-throughput

0.536

High

407449

K2C1
Keratin, type II cytoskeletal 1

1

6

High-throughput

0.536

High

456734

ANXA2
Annexin A2

1

1

High-throughput

0.536

High

471836

RU2B
U2 small nuclear ribonucleoprotein B''

1

1

High-throughput

0.536

High

474685

VIME
Vimentin

1

6

High-throughput

0.536

High

476316

K1C16
Keratin, type I cytoskeletal 16

1

8

High-throughput

0.536

High

535074

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.536

High

566152

K1C10
Keratin, type I cytoskeletal 10

1

9

High-throughput

0.536

High

566384

K2C5
Keratin, type II cytoskeletal 5

1

5

High-throughput

0.536

High

637520

FLNA
Filamin-A

1

1

High-throughput

0.536

High

732315

PRDX2
Peroxiredoxin-2

1

1

High-throughput

0.536

High

772000

K1C9
Keratin, type I cytoskeletal 9

1

8

High-throughput

0.536

High

777469

K22E
Keratin, type II cytoskeletal 2 epidermal

1

6

High-throughput

0.536

High

801324

HSPA9
Stress-70 protein, mitochondrial

1

2

High-throughput

0.536

High

925923

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

1

High-throughput

0.536

High

952827

ACTB
Actin, cytoplasmic 1

1

1

High-throughput

0.536

High

965680

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

1

High-throughput

0.536

High

971541

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.536

High

1027468

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

1

High-throughput

0.536

High

1057153

PRDX1
Peroxiredoxin-1

1

1

High-throughput

0.536

High

1136433

PCBP2
Poly(rC)-binding protein 2

1

1

High-throughput

0.536

High

1136440

FILA2
Filaggrin-2

1

1

High-throughput

0.536

High

1136443

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

1

High-throughput

0.536

High

1136449

ZSC25
Zinc finger and SCAN domain-containing protein 25

1

1

High-throughput

0.536

High

1136450

H3C
Histone H3.3C

1

2

High-throughput

0.536

High

1136456

HAKAI
E3 ubiquitin-protein ligase Hakai

1

1

High-throughput

0.536

High

1136463

HORN
Hornerin

1

1

High-throughput

0.536

High

1136469

RB15B
Putative RNA-binding protein 15B

1

2

High-throughput

0.536

High

1136478

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

1

High-throughput

0.536

High

1136483

RBM15
RNA-binding protein 15

1

3

High-throughput

0.536

High

1136490

TBA1C
Tubulin alpha-1C chain

1

1

High-throughput

0.536

High

1136517

LSM4
U6 snRNA-associated Sm-like protein LSm4

1

1

High-throughput

0.536

High

833270

PERI
Peripherin

1

6

High-throughput

0.515

High

256624

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

0

High-throughput

0.513

High

256862

H2B1K
Histone H2B type 1-K

1

0

High-throughput

0.513

High

295979

TPC6A
Trafficking protein particle complex subunit 6A

1

0

High-throughput

0.513

High

325843

UBR5
E3 ubiquitin-protein ligase UBR5

1

0

High-throughput

0.513

High

370301

CYTA
Cystatin-A

1

0

High-throughput

0.513

High

390047

ALBU
Albumin

1

0

High-throughput

0.513

High

457447

TBB5
Tubulin beta chain

1

0

High-throughput

0.513

High

471029

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.513

High

501991

H2AZ
Histone H2A.Z

1

0

High-throughput

0.513

High

507993

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.513

High

528255

THIO
Thioredoxin

1

0

High-throughput

0.513

High

542027

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

584758

NDKA
Nucleoside diphosphate kinase A

1

0

High-throughput

0.513

High

587664

DESP
Desmoplakin

1

0

High-throughput

0.513

High

608604

DDX5
Probable ATP-dependent RNA helicase DDX5

1

0

High-throughput

0.513

High

646845

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.513

High

729276

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

0

High-throughput

0.513

High

729561

CASPE
Caspase-14

1

0

High-throughput

0.513

High

788659

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.513

High

841737

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.513

High

846612

MSH2
DNA mismatch repair protein Msh2

1

0

High-throughput

0.513

High

912502

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

0

High-throughput

0.513

High

991538

DYL1
Dynein light chain 1, cytoplasmic

1

0

High-throughput

0.513

High

996155

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.513

High

1024042

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.513

High

1056734

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.513

High

1065202

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.513

High

1099908

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.513

High

1118213

BLMH
Bleomycin hydrolase

1

0

High-throughput

0.513

High

1136436

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.513

High

1136441

SAMD9
Sterile alpha motif domain-containing protein 9

1

0

High-throughput

0.513

High

1136455

FBX50
F-box only protein 50

1

0

High-throughput

0.513

High

1136474

GRK7
Rhodopsin kinase GRK7

1

0

High-throughput

0.513

High

1136476

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

0

High-throughput

0.513

High

1136480

THA11
THAP domain-containing protein 11

1

0

High-throughput

0.513

High

1136486

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.513

High

1136488

SH3G2
Endophilin-A1

1

0

High-throughput

0.513

High

1136498

BRMS1
Breast cancer metastasis-suppressor 1

1

0

High-throughput

0.513

High

1136507

DJB11
DnaJ homolog subfamily B member 11

1

0

High-throughput

0.513

High

1136510

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.513

High

1136515

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

0

High-throughput

0.513

High

691019

1433T
14-3-3 protein theta

1

3

High-throughput

0.501

High

216695

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.493

High

245943

KIF1B
Kinesin-like protein KIF1B

1

0

High-throughput

0.493

High

843568

HD
Huntingtin

1

0

High-throughput

0.493

High

926992

ATX3
Ataxin-3

1

0

High-throughput

0.493

High

954472

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.493

High

389368

FINC
Fibronectin

1

1

High-throughput

0.489

High

407292

K2C6B
Keratin, type II cytoskeletal 6B

1

6

High-throughput

0.489

High

447759

TPM3
Tropomyosin alpha-3 chain

1

2

High-throughput

0.489

High

457967

TRY1
Serine protease 1

1

1

High-throughput

0.489

High

482901

TPM1
Tropomyosin alpha-1 chain

1

2

High-throughput

0.489

High

762235

TRY3
Trypsin-3

1

1

High-throughput

0.489

High

882675

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.489

High

995418

TPM4
Tropomyosin alpha-4 chain

1

2

High-throughput

0.489

High

1047417

K1C17
Keratin, type I cytoskeletal 17

1

8

High-throughput

0.489

High

1052020

CALD1
Caldesmon

1

1

High-throughput

0.489

High

1052144

COEA1
Collagen alpha-1(XIV) chain

1

1

High-throughput

0.489

High

1127788

K1H2
Keratin, type I cuticular Ha2

1

8

High-throughput

0.489

High

1136459

K2C1B
Keratin, type II cytoskeletal 1b

1

7

High-throughput

0.489

High

1136467

K2C78
Keratin, type II cytoskeletal 78

1

7

High-throughput

0.489

High

1136503

KRT82
Keratin, type II cuticular Hb2

1

5

High-throughput

0.489

High

185709

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

315594

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

372061

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

406192

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

606781

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

700639

PSA5
Proteasome subunit alpha type-5

1

1

Small-scale

0.479

High

832719

BCL6
B-cell lymphoma 6 protein

1

1

Small-scale

0.479

High

854855

RECQ1
ATP-dependent DNA helicase Q1

1

2

High-throughput

0.479

High

1016870

H33
Histone H3.3

1

2

High-throughput

0.479

High

1136437

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

1136448

IFIX
Pyrin and HIN domain-containing protein 1

1

1

High-throughput

0.479

High

1136479

SH3K1
SH3 domain-containing kinase-binding protein 1

1

2

High-throughput

0.479

High

791388

SYUA
Alpha-synuclein

1

0

High-throughput

0.460

High

1136434

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

0

High-throughput

0.460

High

1136499

EXOS4
Exosome complex component RRP41

1

0

High-throughput

0.460

High

1136502

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.460

High

1136506

GTSE1
G2 and S phase-expressed protein 1

1

0

High-throughput

0.460

High

129093

MEN1
Menin

1

0

High-throughput

0.458

High

461485

HS90A
Heat shock protein HSP 90-alpha

1

0

Small-scale

0.458

High

472747

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

593110

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.458

High

698669

CALX
Calnexin

1

0

High-throughput

0.458

High

703592

MK01
Mitogen-activated protein kinase 1

1

0

Small-scale

0.458

High

714861

EF1D
Elongation factor 1-delta

1

0

High-throughput

0.458

High

786612

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

0

High-throughput

0.458

High

904727

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

1088844

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1136451

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

1136454

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1136465

IFT20
Intraflagellar transport protein 20 homolog

1

0

High-throughput

0.458

High

1136471

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

1136473

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1136477

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1136482

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1136484

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

1136492

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

1136494

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1136501

ANLN
Anillin

1

0

High-throughput

0.458

High

1136505

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1136508

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1136513

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

1136514

FBW1A
F-box/WD repeat-containing protein 1A

1

0

High-throughput

0.458

High

429911

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

877484

HSP77
Putative heat shock 70 kDa protein 7

1

1

High-throughput

0.445

High

883544

CENPA
Histone H3-like centromeric protein A

1

2

Small-scale

0.445

High

1136439

ODFP2
Outer dense fiber protein 2

1

1

High-throughput

0.445

High

1136509

DDX41
Probable ATP-dependent RNA helicase DDX41

1

1

High-throughput

0.445

High

1136445

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.437

High

1136511

HECD1
E3 ubiquitin-protein ligase HECTD1

1

2

High-throughput

0.437

High

1016443

SRSF3
Serine/arginine-rich splicing factor 3

1

0

High-throughput

0.426

High

1136438

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.426

High

1136464

LACC1
Purine nucleoside phosphorylase LACC1

1

0

Small-scale

0.426

High

1136470

SRFB1
Serum response factor-binding protein 1

1

0

High-throughput

0.426

High

1136472

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.426

High

1136491

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.426

High

1136496

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

1136504

HYPK
Huntingtin-interacting protein K

1

0

High-throughput

0.426

High

1136516

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

High-throughput

0.426

High

378736

KV133
Immunoglobulin kappa variable 1-33

1

2

High-throughput

0.407

High

378747

KVD12
Immunoglobulin kappa variable 1D-12

1

2

High-throughput

0.407

High

1010402

LV321
Immunoglobulin lambda variable 3-21

1

2

High-throughput

0.407

High

1136466

VPS52
Vacuolar protein sorting-associated protein 52 homolog

4

0

High-throughput

0.365

High

1136489

KXDL1
KxDL motif-containing protein 1

2

0

High-throughput

0.328

High

1136481

BORC6
BLOC-1-related complex subunit 6

2

0

High-throughput

0.318

High

1136453

ABH15
Protein ABHD15

2

0

High-throughput

0.316

High

501822

CO4A
Complement C4-A

1

0

High-throughput

0.279

Low

866688

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.279

Low

1010622

DCD
Dermcidin

1

0

High-throughput

0.279

Low

1136444

KPLCE
Protein KPLCE

1

0

High-throughput

0.279

Low

1136446

CR063
Uncharacterized protein C18orf63

1

0

High-throughput

0.279

Low

1136462

ZSWM9
Uncharacterized protein ZSWIM9

1

0

High-throughput

0.279

Low

1136475

PIGB
GPI alpha-1,2-mannosyltransferase 3

1

0

High-throughput

0.279

Low

1136487

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

0

High-throughput

0.279

Low

1136512

COR1C
Coronin-1C

1

0

High-throughput

0.279

Low

301430

WFS1
Wolframin

1

0

High-throughput

0.268

Low

456233

CATD
Cathepsin D

1

0

High-throughput

0.268

Low

105955

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

652632

CAH4
Carbonic anhydrase 4

1

0

Small-scale

0.249

Low

1136500

NGB
Neuroglobin

1

0

High-throughput

0.249

Low

62524

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low

213133

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.232

Low

379247

IGHG1
Immunoglobulin heavy constant gamma 1

1

0

High-throughput

0.232

Low

1136442

CE170
Centrosomal protein of 170 kDa

1

0

High-throughput

0.232

Low

1136495

GHC1
Mitochondrial glutamate carrier 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025