Protein: SGK1
Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1)

Gene: SGK1
Organism: Homo sapiens
Interactions: 106
UniProt ID: O00141

Gene Ontology (top 5):
GO:0001558 - regulation of cell growth
GO:0004674 - protein serine/threonine kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0005246 - calcium channel regulator activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

116945

PDPK1
3-phosphoinositide-dependent protein kinase 1

4

19

Small-scale

0.888

High

117002

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

3

12

High-throughput

0.855

High

116943

CETN3
Centrin-3

2

1

High-throughput

0.783

High

116953

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

20

Small-scale

0.754

High

117029

WNK1
Serine/threonine-protein kinase WNK1

2

17

Small-scale

0.754

High

117015

LPP60
60 kDa lysophospholipase

1

9

Small-scale

0.740

High

116983

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

6

Small-scale

0.735

High

117024

NED4L
E3 ubiquitin-protein ligase NEDD4-like

6

20

Small-scale

0.727

High

116941

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

20

Small-scale

0.724

High

117022

WNK4
Serine/threonine-protein kinase WNK4

1

17

Small-scale

0.724

High

116999

MK07
Mitogen-activated protein kinase 7

1

20

Small-scale

0.709

High

116950

RASH
GTPase HRas

1

8

High-throughput

0.691

High

116984

NEDD4
E3 ubiquitin-protein ligase NEDD4

4

20

Small-scale

0.686

High

116961

TAU
Microtubule-associated protein tau

3

15

Small-scale

0.682

High

116951

PIGR
Polymeric immunoglobulin receptor

1

1

High-throughput

0.665

High

117008

CDC37
Hsp90 co-chaperone Cdc37

1

14

High-throughput

0.665

High

116939

SGK1
Serine/threonine-protein kinase Sgk1

1

18

Small-scale

0.647

High

116959

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

15

High-throughput

0.647

High

117027

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

14

Small-scale

0.647

High

116980

MTOR
Serine/threonine-protein kinase mTOR

2

18

Small-scale

0.646

High

117007

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

2

20

Small-scale

0.639

High

117012

RICTR
Rapamycin-insensitive companion of mTOR

2

7

Small-scale

0.629

High

116956

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

116958

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

116960

RAP2A
Ras-related protein Rap-2a

1

5

High-throughput

0.618

High

116962

PABP1
Polyadenylate-binding protein 1

1

7

High-throughput

0.618

High

116965

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

5

High-throughput

0.618

High

116990

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

5

High-throughput

0.618

High

117016

RPTOR
Regulatory-associated protein of mTOR

1

15

Small-scale

0.618

High

117025

KKCC2
Calcium/calmodulin-dependent protein kinase kinase 2

1

15

Small-scale

0.618

High

117038

WNK2
Serine/threonine-protein kinase WNK2

1

17

Small-scale

0.618

High

117034

NDRG4
Protein NDRG4

2

2

High-throughput

0.606

High

117037

CHSP1
Calcium-regulated heat-stable protein 1

1

3

Small-scale

0.586

High

117026

T22D3
TSC22 domain family protein 3

2

3

Small-scale

0.584

High

117035

CHIP
E3 ubiquitin-protein ligase CHIP

2

7

Small-scale

0.584

High

116991

IMA1
Importin subunit alpha-1

1

4

Small-scale

0.573

High

117041

NEMO
NF-kappa-B essential modulator

1

19

High-throughput

0.561

High

117023

ARL5B
ADP-ribosylation factor-like protein 5B

2

4

High-throughput

0.558

High

117020

MAL2
Protein MAL2

2

1

High-throughput

0.553

High

116982

MAGA1
Melanoma-associated antigen 1

1

6

Small-scale

0.541

High

117003

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

Small-scale

0.537

High

117040

CSDC2
Cold shock domain-containing protein C2

1

3

Small-scale

0.536

High

116967

CREB1
Cyclic AMP-responsive element-binding protein 1

1

1

Small-scale

0.527

High

117033

PRAF1
Prenylated Rab acceptor protein 1

1

0

High-throughput

0.518

High

116952

TRFL
Lactotransferrin

1

1

High-throughput

0.515

High

116969

TNR5
Tumor necrosis factor receptor superfamily member 5

1

8

High-throughput

0.515

High

116986

EFTU
Elongation factor Tu, mitochondrial

1

9

High-throughput

0.515

High

116987

TSC2
Tuberin

1

1

Small-scale

0.515

High

116992

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.515

High

116998

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

6

High-throughput

0.515

High

117036

PA2G4
Proliferation-associated protein 2G4

1

2

High-throughput

0.515

High

116979

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

8

Small-scale

0.501

High

116996

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

15

Small-scale

0.501

High

117006

PDK1
[Pyruvate dehydrogenase

1

6

Small-scale

0.501

High

117019

NDRG1
Protein NDRG1

1

2

Small-scale

0.501

High

117028

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

5

Small-scale

0.501

High

116974

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.493

High

116944

FANCA
Fanconi anemia group A protein

1

1

Small-scale

0.481

High

116981

AF9
Protein AF-9

1

0

Small-scale

0.480

High

99719

PAL4D
Peptidyl-prolyl cis-trans isomerase A-like 4D

1

3

High-throughput

0.479

High

116940

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

3

High-throughput

0.479

High

116946

CISY
Citrate synthase, mitochondrial

1

2

High-throughput

0.479

High

116947

CBR3
Carbonyl reductase [NADPH] 3

1

3

High-throughput

0.479

High

116954

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

6

High-throughput

0.479

High

116955

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

8

High-throughput

0.479

High

116957

MCR
Mineralocorticoid receptor

1

17

Small-scale

0.479

High

116964

MYH1
Myosin-1

1

6

High-throughput

0.479

High

116966

EZRI
Ezrin

1

10

High-throughput

0.479

High

116968

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

1

High-throughput

0.479

High

116970

DDX6
Probable ATP-dependent RNA helicase DDX6

1

11

High-throughput

0.479

High

116971

SYVC
Valine--tRNA ligase

1

6

High-throughput

0.479

High

116972

1433T
14-3-3 protein theta

1

20

Small-scale

0.479

High

116973

ATPD
ATP synthase subunit delta, mitochondrial

1

1

High-throughput

0.479

High

116975

HSP74
Heat shock 70 kDa protein 4

1

20

Small-scale

0.479

High

116976

CTNB1
Catenin beta-1

1

6

Small-scale

0.479

High

116977

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

116978

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

116985

NASP
Nuclear autoantigenic sperm protein

1

1

High-throughput

0.479

High

116988

GDIB
Rab GDP dissociation inhibitor beta

1

2

High-throughput

0.479

High

116994

RS3A
Small ribosomal subunit protein eS1

1

2

High-throughput

0.479

High

116995

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.479

High

116997

CDC20
Cell division cycle protein 20 homolog

1

10

High-throughput

0.479

High

117000

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

7

High-throughput

0.479

High

117005

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

3

High-throughput

0.479

High

117009

FSCN1
Fascin

1

4

High-throughput

0.479

High

117010

FA98B
Protein FAM98B

1

1

High-throughput

0.479

High

117011

Q6NVI1
Myristoylated alanine-rich C-kinase substrate

1

4

High-throughput

0.479

High

117013

MYH14
Myosin-14

1

6

High-throughput

0.479

High

117014

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

9

Small-scale

0.479

High

117017

COMD1
COMM domain-containing protein 1

1

1

Small-scale

0.479

High

117018

IPO4
Importin-4

1

3

High-throughput

0.479

High

117021

AKTS1
Proline-rich AKT1 substrate 1

1

4

Small-scale

0.479

High

117030

MOB1A
MOB kinase activator 1A

1

1

High-throughput

0.479

High

117031

OLA1
Obg-like ATPase 1

1

1

High-throughput

0.479

High

117039

HYOU1
Hypoxia up-regulated protein 1

1

20

High-throughput

0.479

High

116949

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

0

High-throughput

0.460

High

116942

PUR4
Phosphoribosylformylglycinamidine synthase

1

0

High-throughput

0.458

High

116948

LETM1
Mitochondrial proton/calcium exchanger protein

1

0

High-throughput

0.458

High

116963

PIP
Prolactin-inducible protein

1

0

High-throughput

0.458

High

116989

SCNNB
Amiloride-sensitive sodium channel subunit beta

1

0

Small-scale

0.458

High

116993

PSA6
Proteasome subunit alpha type-6

1

0

High-throughput

0.458

High

117001

SF3B2
Splicing factor 3B subunit 2

1

0

High-throughput

0.458

High

117004

GANAB
Neutral alpha-glucosidase AB

1

1

High-throughput

0.437

High

117032

T184C
Transmembrane protein 184C

1

0

High-throughput

0.282

High

49061

A0N4V7
HCG2039797

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024