Protein: SF3B6
Splicing factor 3B subunit 6 (Pre-mRNA branch site protein p14) (SF3b 14 kDa subunit) (SF3B14a) (Spliceosome-associated protein, 14-kDa) (Splicing factor 3b, subunit 6, 14kDa)

Gene: SF3B6
Organism: Homo sapiens
Interactions: 169
UniProt ID: Q9Y3B4

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0001825 - blastocyst formation
GO:0003723 - RNA binding
GO:0003729 - mRNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

286121

SF3B1
Splicing factor 3B subunit 1

11

4

Small-scale

0.977

High

485768

RU2A
U2 small nuclear ribonucleoprotein A'

3

9

High-throughput

0.861

High

1148092

SF3B3
Splicing factor 3B subunit 3

3

7

Small-scale

0.853

High

1148677

SF3A2
Splicing factor 3A subunit 2

3

9

Small-scale

0.847

High

471952

RU2B
U2 small nuclear ribonucleoprotein B''

2

19

High-throughput

0.811

High

1088758

SF3A3
Splicing factor 3A subunit 3

2

3

High-throughput

0.789

High

1105448

SF3B2
Splicing factor 3B subunit 2

2

4

High-throughput

0.789

High

1127272

RBM39
RNA-binding protein 39

2

18

High-throughput

0.789

High

1148579

SF3B4
Splicing factor 3B subunit 4

2

17

High-throughput

0.789

High

225346

HTSF1
17S U2 SnRNP complex component HTATSF1

1

18

High-throughput

0.691

High

227186

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

20

High-throughput

0.691

High

478266

SNRPA
U1 small nuclear ribonucleoprotein A

1

19

High-throughput

0.691

High

1152360

U2AFM
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

1

4

High-throughput

0.691

High

1348868

ZCRB1
Zinc finger CCHC-type and RNA-binding motif-containing protein 1

1

18

High-throughput

0.691

High

1397625

RNPC3
RNA-binding region-containing protein 3

1

16

High-throughput

0.691

High

973853

RUXE
Small nuclear ribonucleoprotein E

3

4

High-throughput

0.675

High

1390386

CCD97
Coiled-coil domain-containing protein 97

3

2

High-throughput

0.675

High

1274064

PHF5A
PHD finger-like domain-containing protein 5A

3

2

Small-scale

0.670

High

1416257

SF3B5
Splicing factor 3B subunit 5

3

3

Small-scale

0.660

High

685785

U2AF2
Splicing factor U2AF 65 kDa subunit

1

20

Small-scale

0.647

High

373573

MYC
Myc proto-oncogene protein

3

15

High-throughput

0.640

High

1452215

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

2

1

High-throughput

0.635

High

134923

SAP18
Histone deacetylase complex subunit SAP18

1

6

High-throughput

0.618

High

349302

LATS1
Serine/threonine-protein kinase LATS1

1

3

High-throughput

0.618

High

401742

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

10

High-throughput

0.618

High

920388

PLK1
Serine/threonine-protein kinase PLK1

1

3

High-throughput

0.618

High

1088633

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

14

High-throughput

0.618

High

1122594

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

5

High-throughput

0.618

High

1133067

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

14

High-throughput

0.618

High

1194479

LARP7
La-related protein 7

1

19

High-throughput

0.618

High

1197607

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

6

High-throughput

0.618

High

1459408

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.618

High

1461062

TNIK
TRAF2 and NCK-interacting protein kinase

1

8

High-throughput

0.618

High

298468

DNJC8
DnaJ homolog subfamily C member 8

2

1

High-throughput

0.611

High

974223

RUXG
Small nuclear ribonucleoprotein G

2

20

High-throughput

0.611

High

1404533

CDC5L
Cell division cycle 5-like protein

2

7

High-throughput

0.611

High

831689

CCNF
Cyclin-F

2

7

High-throughput

0.601

High

129583

MEN1
Menin

2

4

High-throughput

0.584

High

1452068

MCM9
DNA helicase MCM9

2

6

Small-scale

0.584

High

1150854

SF01
Splicing factor 1

1

9

High-throughput

0.575

High

1209821

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.575

High

397287

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1244722

TTC33
Tetratricopeptide repeat protein 33

2

4

High-throughput

0.558

High

1087702

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

9

High-throughput

0.553

High

619963

VCAM1
Vascular cell adhesion protein 1

2

6

High-throughput

0.549

High

480360

RU1C
U1 small nuclear ribonucleoprotein C

1

7

High-throughput

0.536

High

484691

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

574527

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

9

High-throughput

0.536

High

634707

LMNB1
Lamin-B1

1

3

High-throughput

0.536

High

641072

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

3

High-throughput

0.536

High

788276

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.536

High

884282

SRP09
Signal recognition particle 9 kDa protein

1

1

High-throughput

0.536

High

952035

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

7

High-throughput

0.536

High

974088

RUXF
Small nuclear ribonucleoprotein F

1

16

High-throughput

0.536

High

974496

SMD1
Small nuclear ribonucleoprotein Sm D1

1

17

High-throughput

0.536

High

974700

SMD2
Small nuclear ribonucleoprotein Sm D2

1

5

High-throughput

0.536

High

1111381

SNW1
SNW domain-containing protein 1

1

5

High-throughput

0.536

High

1149234

SF3A1
Splicing factor 3A subunit 1

1

7

High-throughput

0.536

High

1231226

KDM4D
Lysine-specific demethylase 4D

1

1

High-throughput

0.536

High

1234633

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

1

High-throughput

0.536

High

1270683

COX15
Heme A synthase COX15

1

2

High-throughput

0.536

High

1290846

ZCH18
Zinc finger CCCH domain-containing protein 18

1

19

High-throughput

0.536

High

1291300

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

10

High-throughput

0.536

High

1294133

DDX42
ATP-dependent RNA helicase DDX42

1

12

High-throughput

0.536

High

1311574

SUGP1
SURP and G-patch domain-containing protein 1

1

5

High-throughput

0.536

High

1358936

PCNP
PEST proteolytic signal-containing nuclear protein

1

1

High-throughput

0.536

High

1406668

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

3

High-throughput

0.536

High

1416396

NADAP
Kanadaptin

1

10

High-throughput

0.536

High

1428709

SKI8
Superkiller complex protein 8

1

14

High-throughput

0.536

High

1437087

AGO3
Protein argonaute-3

1

9

High-throughput

0.536

High

641713

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

4

High-throughput

0.526

High

1462250

RHG26
Rho GTPase-activating protein 26

2

3

High-throughput

0.521

High

354812

PAK4
Serine/threonine-protein kinase PAK 4

1

7

High-throughput

0.514

High

617760

XRCC1
DNA repair protein XRCC1

1

0

High-throughput

0.513

High

1234229

SNR48
U11/U12 small nuclear ribonucleoprotein 48 kDa protein

1

0

High-throughput

0.513

High

1415028

SNR25
U11/U12 small nuclear ribonucleoprotein 25 kDa protein

1

0

High-throughput

0.513

High

1416204

SCNM1
Sodium channel modifier 1

1

0

High-throughput

0.513

High

1491138

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.513

High

135740

DNM1L
Dynamin-1-like protein

1

1

High-throughput

0.489

High

389579

FINC
Fibronectin

1

7

High-throughput

0.489

High

567118

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

2

High-throughput

0.489

High

1331527

GPT11
G patch domain-containing protein 11

1

1

High-throughput

0.489

High

1435943

IFT22
Intraflagellar transport protein 22 homolog

1

2

High-throughput

0.489

High

785549

RL4
Large ribosomal subunit protein uL4

1

4

High-throughput

0.481

High

248159

NUPR1
Nuclear protein 1

1

6

High-throughput

0.479

High

285535

EED
Polycomb protein EED

1

20

High-throughput

0.479

High

298557

SPF30
Survival of motor neuron-related-splicing factor 30

1

5

High-throughput

0.479

High

320172

UFL1
E3 UFM1-protein ligase 1

1

5

High-throughput

0.479

High

325183

HEXI1
Protein HEXIM1

1

7

High-throughput

0.479

High

406829

MYCN
N-myc proto-oncogene protein

1

15

High-throughput

0.479

High

590098

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

607253

CEBPB
CCAAT/enhancer-binding protein beta

1

9

High-throughput

0.479

High

626412

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

3

High-throughput

0.479

High

659644

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.479

High

696938

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

766965

PHB1
Prohibitin 1

1

4

High-throughput

0.479

High

769583

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

879651

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

8

High-throughput

0.479

High

905326

MECP2
Methyl-CpG-binding protein 2

1

8

High-throughput

0.479

High

937989

FOXA1
Hepatocyte nuclear factor 3-alpha

1

2

High-throughput

0.479

High

965355

WDR5
WD repeat-containing protein 5

1

16

High-throughput

0.479

High

971333

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

1024951

VIGLN
Vigilin

1

20

High-throughput

0.479

High

1027870

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

12

High-throughput

0.479

High

1036013

KIF23
Kinesin-like protein KIF23

1

15

High-throughput

0.479

High

1067866

EP300
Histone acetyltransferase p300

1

14

High-throughput

0.479

High

1092280

NFX1
Transcriptional repressor NF-X1

1

4

High-throughput

0.479

High

1115491

CUL4B
Cullin-4B

1

20

High-throughput

0.479

High

1121384

TRI14
Tripartite motif-containing protein 14

1

8

High-throughput

0.479

High

1137603

SUZ12
Polycomb protein SUZ12

1

4

High-throughput

0.479

High

1138795

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

7

High-throughput

0.479

High

1141085

KIF14
Kinesin-like protein KIF14

1

10

High-throughput

0.479

High

1229784

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

1235579

IFIX
Pyrin and HIN domain-containing protein 1

1

6

High-throughput

0.479

High

1241864

PRP8
Pre-mRNA-processing-splicing factor 8

1

5

High-throughput

0.479

High

1258425

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.479

High

1277009

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.479

High

1347000

SNIP1
Smad nuclear-interacting protein 1

1

7

High-throughput

0.479

High

1352854

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

4

High-throughput

0.479

High

1367658

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1384711

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

3

High-throughput

0.479

High

1385662

DCPS
m7GpppX diphosphatase

1

2

High-throughput

0.479

High

1387659

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

16

High-throughput

0.479

High

1397584

CI072
Guanine nucleotide exchange factor C9orf72

1

7

High-throughput

0.479

High

1401464

CIC
Protein capicua homolog

1

16

High-throughput

0.479

High

1417535

FACD2
Fanconi anemia group D2 protein

1

7

High-throughput

0.479

High

1421029

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

1429409

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.479

High

1447032

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

5

High-throughput

0.479

High

1453188

WWOX
WW domain-containing oxidoreductase

1

4

High-throughput

0.479

High

1491025

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.479

High

1491137

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

1

High-throughput

0.479

High

1293574

ZFAN4
AN1-type zinc finger protein 4

1

10

High-throughput

0.470

High

135842

RTCA
RNA 3'-terminal phosphate cyclase

1

0

High-throughput

0.458

High

822918

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

927182

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

960617

PSME3
Proteasome activator complex subunit 3

1

0

Small-scale

0.458

High

423506

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.457

High

71629

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

20

High-throughput

0.445

High

207687

DHX15
ATP-dependent RNA helicase DHX15

1

13

High-throughput

0.445

High

430548

JUN
Transcription factor Jun

1

10

High-throughput

0.445

High

530640

TAU
Microtubule-associated protein tau

1

12

High-throughput

0.445

High

1103467

CTBP1
C-terminal-binding protein 1

1

4

High-throughput

0.445

High

1420775

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

1461383

AGO1
Protein argonaute-1

1

9

High-throughput

0.445

High

294566

CD123
Translation initiation factor eIF2 assembly protein

1

6

High-throughput

0.437

High

318923

RHBT1
Rho-related BTB domain-containing protein 1

1

11

High-throughput

0.437

High

565496

ITA4
Integrin alpha-4

1

4

High-throughput

0.437

High

1049215

RON
Macrophage-stimulating protein receptor

1

5

High-throughput

0.437

High

1060726

SOS2
Son of sevenless homolog 2

1

2

High-throughput

0.437

High

1135192

CUL7
Cullin-7

1

9

High-throughput

0.437

High

1227755

A16L1
Autophagy-related protein 16-1

1

15

High-throughput

0.437

High

1256210

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

1328572

NGEF
Ephexin-1

1

13

High-throughput

0.437

High

1348263

TIP
T-cell immunomodulatory protein

1

3

High-throughput

0.437

High

1358150

NUDC2
NudC domain-containing protein 2

1

3

High-throughput

0.437

High

1385929

CHM4C
Charged multivesicular body protein 4c

1

9

High-throughput

0.437

High

1434300

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.437

High

1454235

RHG23
Rho GTPase-activating protein 23

1

6

High-throughput

0.437

High

1491139

PHLA3
Pleckstrin homology-like domain family A member 3

1

1

High-throughput

0.437

High

47010

PNT87
Transcriptional regulator PINT87aa

1

0

Small-scale

0.426

High

887368

CEBPA
CCAAT/enhancer-binding protein alpha

1

9

High-throughput

0.408

High

87564

OSCRI
SCRIB overlapping open reading frame protein

1

3

High-throughput

0.407

High

1034546

TAGL
Transgelin

1

2

High-throughput

0.407

High

378730

IGJ
Immunoglobulin J chain

1

0

High-throughput

0.279

Low

904214

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.269

Low

956123

SPCS3
Signal peptidase complex subunit 3

1

0

High-throughput

0.249

Low

1178477

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1384837

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025