Protein: TRFL
Lactotransferrin (Lactoferrin) (EC 3.4.21.-) (Growth-inhibiting protein 12) (Talalactoferrin) [Cleaved into: Lactoferricin-H (Lfcin-H); Kaliocin-1; Lactoferroxin-A; Lactoferroxin-B; Lactoferroxin-C]

Gene: TRFL, LTF
Organism: Homo sapiens
Interactions: 158
UniProt ID: P02788

Gene Ontology (top 5):
GO:0001503 - ossification
GO:0001530 - lipopolysaccharide binding
GO:0001817 - regulation of cytokine production
GO:0002227 - innate immune response in mucosa
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

391098

SIRPG
Signal-regulatory protein gamma

2

2

High-throughput

0.789

High

390836

TRFE
Serotransferrin

2

1

High-throughput

0.754

High

391101

DPOLL
DNA polymerase lambda

3

1

High-throughput

0.656

High

391070

SNX27
Sorting nexin-27

2

1

High-throughput

0.628

High

391087

DDX31
ATP-dependent DNA helicase DDX31

2

2

High-throughput

0.628

High

391105

DD19B
ATP-dependent RNA helicase DDX19B

2

2

High-throughput

0.611

High

391073

CDK15
Cyclin-dependent kinase 15

2

0

High-throughput

0.602

High

390988

ZN250
Zinc finger protein 250

2

0

High-throughput

0.585

High

391074

TM237
Transmembrane protein 237

2

0

High-throughput

0.585

High

391002

CEBPA
CCAAT/enhancer-binding protein alpha

2

4

Small-scale

0.584

High

391027

CEBPE
CCAAT/enhancer-binding protein epsilon

2

4

Small-scale

0.584

High

391033

HBM
Hemoglobin subunit mu

2

2

High-throughput

0.574

High

391016

OCRL
Inositol polyphosphate 5-phosphatase OCRL

2

0

High-throughput

0.547

High

391037

RHGBA
Rho GTPase-activating protein 11A

2

0

High-throughput

0.547

High

390982

CD14
Monocyte differentiation antigen CD14

1

0

Small-scale

0.537

High

141977

FCN1
Ficolin-1

1

3

High-throughput

0.536

High

191898

MAGB4
Melanoma-associated antigen B4

1

1

High-throughput

0.536

High

210161

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

1

High-throughput

0.536

High

210668

KLK10
Kallikrein-10

1

4

High-throughput

0.536

High

255515

GALR3
Galanin receptor type 3

1

2

High-throughput

0.536

High

390986

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

390990

AATC
Aspartate aminotransferase, cytoplasmic

1

1

High-throughput

0.536

High

390995

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.536

High

390999

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

1

High-throughput

0.536

High

391005

GSK3A
Glycogen synthase kinase-3 alpha

1

1

High-throughput

0.536

High

391006

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.536

High

391007

PRKX
cAMP-dependent protein kinase catalytic subunit PRKX

1

2

High-throughput

0.536

High

391039

AEBP2
Zinc finger protein AEBP2

1

1

High-throughput

0.536

High

391042

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

1

High-throughput

0.536

High

391045

TEX14
Inactive serine/threonine-protein kinase TEX14

1

1

High-throughput

0.536

High

391059

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.536

High

391060

ITLN2
Intelectin-2

1

1

High-throughput

0.536

High

391069

SCYL1
N-terminal kinase-like protein

1

1

High-throughput

0.536

High

391076

SRPK1
SRSF protein kinase 1

1

2

High-throughput

0.536

High

391079

EGFL8
Epidermal growth factor-like protein 8

1

2

High-throughput

0.536

High

391092

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

1

High-throughput

0.536

High

391102

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

1

High-throughput

0.536

High

391108

SSUH2
Protein SSUH2 homolog

1

1

High-throughput

0.536

High

122898

SGK1
Serine/threonine-protein kinase Sgk1

1

1

High-throughput

0.515

High

133839

FOXN3
Forkhead box protein N3

1

0

High-throughput

0.513

High

390992

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.513

High

390993

MAK
Serine/threonine-protein kinase MAK

1

0

High-throughput

0.513

High

390996

GLRX1
Glutaredoxin-1

1

0

High-throughput

0.513

High

391004

CLK1
Dual specificity protein kinase CLK1

1

0

High-throughput

0.513

High

391017

TWF1
Twinfilin-1

1

0

High-throughput

0.513

High

391028

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.513

High

391035

LRC8E
Volume-regulated anion channel subunit LRRC8E

1

0

High-throughput

0.513

High

391041

DHX30
ATP-dependent RNA helicase DHX30

1

0

High-throughput

0.513

High

391044

CDKL3
Cyclin-dependent kinase-like 3

1

0

High-throughput

0.513

High

391047

APCD1
Protein APCDD1

1

0

High-throughput

0.513

High

391051

LRC17
Leucine-rich repeat-containing protein 17

1

0

High-throughput

0.513

High

391053

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.513

High

391054

AT11C
Phospholipid-transporting ATPase IG

1

0

High-throughput

0.513

High

391056

O13C3
Olfactory receptor 13C3

1

0

High-throughput

0.513

High

391058

MK15
Mitogen-activated protein kinase 15

1

0

High-throughput

0.513

High

391062

PMEPA
Protein TMEPAI

1

0

High-throughput

0.513

High

391065

SNF8
Vacuolar-sorting protein SNF8

1

0

High-throughput

0.513

High

391066

ERO1A
ERO1-like protein alpha

1

0

High-throughput

0.513

High

391071

PRAP1
Proline-rich acidic protein 1

1

0

High-throughput

0.513

High

391081

USB1
U6 snRNA phosphodiesterase 1

1

0

High-throughput

0.513

High

391089

PPCS
Phosphopantothenate--cysteine ligase

1

0

High-throughput

0.513

High

391090

COE2
Transcription factor COE2

1

0

High-throughput

0.513

High

391091

CP343
Cytochrome P450 3A43

1

0

High-throughput

0.513

High

351297

EPPI
Eppin

1

1

Small-scale

0.501

High

361517

CERU
Ceruloplasmin

1

1

Small-scale

0.501

High

390983

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.501

High

391061

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

High-throughput

0.501

High

391083

ACE2
Angiotensin-converting enzyme 2

1

1

Small-scale

0.501

High

391009

PMS1
PMS1 protein homolog 1

1

0

High-throughput

0.493

High

49388

DHR12
Dehydrogenase/reductase SDR family member 12

1

1

High-throughput

0.489

High

335224

CXB5
Gap junction beta-5 protein

1

3

High-throughput

0.489

High

391036

SFXN4
Sideroflexin-4

1

2

High-throughput

0.489

High

391038

SPNS3
Protein spinster homolog 3

1

1

High-throughput

0.489

High

391063

SARAF
Store-operated calcium entry-associated regulatory factor

1

1

High-throughput

0.489

High

391064

PF21B
PHD finger protein 21B

1

5

High-throughput

0.489

High

391068

SMIM8
Small integral membrane protein 8

1

1

High-throughput

0.489

High

391078

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

1

High-throughput

0.489

High

391096

FKB14
Peptidyl-prolyl cis-trans isomerase FKBP14

1

1

High-throughput

0.489

High

390991

NUCL
Nucleolin

1

0

Small-scale

0.480

High

391011

LYSC
Lysozyme C

1

0

Small-scale

0.480

High

391057

MUC7
Mucin-7

1

0

Small-scale

0.480

High

131651

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

Small-scale

0.479

High

240447

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

370879

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

390978

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

390979

S10A8
Protein S100-A8

1

1

High-throughput

0.479

High

390981

S10A9
Protein S100-A9

1

1

High-throughput

0.479

High

390985

CLUS
Clusterin

1

1

Small-scale

0.479

High

390989

TIMP2
Metalloproteinase inhibitor 2

1

1

High-throughput

0.479

High

390994

PRTN3
Myeloblastin

1

3

High-throughput

0.479

High

390998

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

391003

CEBPD
CCAAT/enhancer-binding protein delta

1

4

Small-scale

0.479

High

391018

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.479

High

391021

DX39B
Spliceosome RNA helicase DDX39B

1

1

High-throughput

0.479

High

391024

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

High-throughput

0.479

High

391034

TET2
Methylcytosine dioxygenase TET2

1

1

Small-scale

0.479

High

391040

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

391072

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

1

Small-scale

0.479

High

391077

NECD
Necdin

1

1

High-throughput

0.479

High

391082

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

391084

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

1

High-throughput

0.479

High

391085

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.479

High

391099

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

2

High-throughput

0.479

High

391103

RCOR1
REST corepressor 1

1

1

High-throughput

0.479

High

391106

TRI33
E3 ubiquitin-protein ligase TRIM33

1

1

High-throughput

0.479

High

391110

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

1

Small-scale

0.479

High

391112

LOXL2
Lysyl oxidase homolog 2

1

2

High-throughput

0.479

High

141267

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

Small-scale

0.458

High

246380

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.458

High

272594

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

0

High-throughput

0.458

High

293025

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

302304

RNF8
E3 ubiquitin-protein ligase RNF8

1

0

High-throughput

0.458

High

390980

PERM
Myeloperoxidase

1

0

High-throughput

0.458

High

390987

HIS3
Histatin-3

1

0

Small-scale

0.458

High

391000

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

High-throughput

0.458

High

391001

TISD
mRNA decay activator protein ZFP36L2

1

0

High-throughput

0.458

High

391008

EFNA3
Ephrin-A3

1

0

High-throughput

0.458

High

391010

EPHA4
Ephrin type-A receptor 4

1

0

High-throughput

0.458

High

391012

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.458

High

391014

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

391015

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

391020

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

391025

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.458

High

391048

CCAR2
Cell cycle and apoptosis regulator protein 2

1

0

High-throughput

0.458

High

391067

CK5P3
CDK5 regulatory subunit-associated protein 3

1

0

High-throughput

0.458

High

391075

RANB9
Ran-binding protein 9

1

0

High-throughput

0.458

High

391093

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

391095

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

391104

FXL21
Putative F-box/LRR-repeat protein 21

1

0

High-throughput

0.458

High

391111

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

390984

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

391019

STK4
Serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

391022

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.445

High

391026

OASL
2'-5'-oligoadenylate synthase-like protein

1

1

High-throughput

0.445

High

391030

Q5JQP4
DNA polymerase

1

1

High-throughput

0.445

High

391050

CD177
CD177 antigen

1

1

Small-scale

0.445

High

391109

PRG3
Proteoglycan 3

1

2

High-throughput

0.445

High

391100

RCOR3
REST corepressor 3

1

1

High-throughput

0.437

High

213030

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.426

High

391023

RFTN1
Raftlin

1

0

High-throughput

0.426

High

391032

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.407

High

391031

ICE2
Little elongation complex subunit 2

3

0

High-throughput

0.347

High

391055

CC148
Coiled-coil domain-containing protein 148

3

0

High-throughput

0.347

High

391088

KT3K
Ketosamine-3-kinase

3

0

High-throughput

0.347

High

391052

FRMD1
FERM domain-containing protein 1

2

0

High-throughput

0.328

High

67419

GOG8A
Golgin subfamily A member 8A

1

0

High-throughput

0.279

Low

354011

CX001
Putative transmembrane protein CXorf1

1

0

High-throughput

0.279

Low

390997

PIGA
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

1

0

High-throughput

0.279

Low

391013

TIM10
Mitochondrial import inner membrane translocase subunit Tim10

1

0

High-throughput

0.279

Low

391029

T176B
Transmembrane protein 176B

1

0

High-throughput

0.279

Low

391046

ELOA2
Elongin-A2

1

0

High-throughput

0.279

Low

391049

RIBC1
RIB43A-like with coiled-coils protein 1

1

0

High-throughput

0.279

Low

391080

RSLBB
Ras-like protein family member 11B

1

0

High-throughput

0.279

Low

391086

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

391043

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.249

Low

391094

ANLN
Anillin

1

0

High-throughput

0.249

Low

391097

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

391107

NINL
Ninein-like protein

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025