Protein: APT
Adenine phosphoribosyltransferase (APRT) (EC 2.4.2.7)

Gene: APT, APRT
Organism: Homo sapiens
Interactions: 90
UniProt ID: P07741

Gene Ontology (top 5):
GO:0002055 - adenine binding
GO:0003999 - adenine phosphoribosyltransferase activity
GO:0005576 - extracellular region
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

459930

NEMO
NF-kappa-B essential modulator

1

1

High-throughput

0.561

High

240516

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

400138

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

0

High-throughput

0.559

High

459885

SQSTM
Sequestosome-1

2

0

High-throughput

0.559

High

459865

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.547

High

459892

KPCD1
Serine/threonine-protein kinase D1

2

0

High-throughput

0.547

High

459894

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

0

High-throughput

0.547

High

459907

MK15
Mitogen-activated protein kinase 15

1

1

High-throughput

0.536

High

459903

UN45B
Protein unc-45 homolog B

1

1

High-throughput

0.515

High

361065

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

459872

PSB10
Proteasome subunit beta type-10

1

0

High-throughput

0.513

High

459902

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

459920

ANKZ1
tRNA endonuclease ANKZF1

1

0

High-throughput

0.513

High

459873

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.493

High

459897

KLH24
Kelch-like protein 24

1

0

High-throughput

0.493

High

459900

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

0

High-throughput

0.493

High

459874

MLH1
DNA mismatch repair protein Mlh1

1

0

Small-scale

0.486

High

421323

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

459880

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

142790

NFIB
Nuclear factor 1 B-type

1

1

High-throughput

0.479

High

188786

TMPS2
Transmembrane protease serine 2

1

1

High-throughput

0.479

High

459856

NFIC
Nuclear factor 1 C-type

1

1

High-throughput

0.479

High

459858

ANDR
Androgen receptor

1

1

High-throughput

0.479

High

459870

DUS1
Dual specificity protein phosphatase 1

1

2

High-throughput

0.479

High

459884

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

1

High-throughput

0.479

High

459898

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

459910

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

459918

DUS21
Dual specificity protein phosphatase 21

1

2

High-throughput

0.479

High

459922

DUS22
Dual specificity protein phosphatase 22

1

3

High-throughput

0.479

High

459926

DUS12
Dual specificity protein phosphatase 12

1

3

High-throughput

0.479

High

352860

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.458

High

362610

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

377158

SOMA
Somatotropin

1

0

High-throughput

0.458

High

385371

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

388912

FINC
Fibronectin

1

0

High-throughput

0.458

High

457175

TBB5
Tubulin beta chain

1

0

High-throughput

0.458

High

459860

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

459861

PLAK
Junction plakoglobin

1

0

High-throughput

0.458

High

459862

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

459863

IL7RA
Interleukin-7 receptor subunit alpha

1

0

High-throughput

0.458

High

459864

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

459867

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

459868

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

459869

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

459871

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

459875

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

459876

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

459878

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

459879

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.458

High

459881

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.458

High

459883

MERTK
Tyrosine-protein kinase Mer

1

0

High-throughput

0.458

High

459886

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.458

High

459887

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.458

High

459888

CUL7
Cullin-7

1

0

High-throughput

0.458

High

459889

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

459891

EEA1
Early endosome antigen 1

1

0

High-throughput

0.458

High

459893

FSCN1
Fascin

1

0

High-throughput

0.458

High

459895

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

459904

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.458

High

459906

NIN
Ninein

1

0

High-throughput

0.458

High

459909

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

459911

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

459913

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

459914

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

459915

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

459916

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

459917

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

459919

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

459923

TRM7
tRNA

1

0

High-throughput

0.458

High

459924

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

459928

TRAF6
TNF receptor-associated factor 6

1

0

High-throughput

0.458

High

192427

INSI1
Insulin-induced gene 1 protein

1

1

High-throughput

0.437

High

459877

GEM
GTP-binding protein GEM

1

1

High-throughput

0.437

High

459908

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.437

High

459912

LMTK3
Serine/threonine-protein kinase LMTK3

1

1

High-throughput

0.437

High

459921

TMPS4
Transmembrane protease serine 4

1

1

High-throughput

0.437

High

459925

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.437

High

459929

INSI2
Insulin-induced gene 2 protein

1

1

High-throughput

0.437

High

459866

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

0

High-throughput

0.426

High

459899

NEK10
Serine/threonine-protein kinase Nek10

1

0

High-throughput

0.426

High

459896

TTC19
Tetratricopeptide repeat protein 19, mitochondrial

2

0

High-throughput

0.316

High

459857

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

318580

RHBT1
Rho-related BTB domain-containing protein 1

1

0

High-throughput

0.249

Low

352293

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.249

Low

459859

IFM1
Interferon-induced transmembrane protein 1

1

0

High-throughput

0.249

Low

459882

CAV1
Caveolin-1

1

0

High-throughput

0.249

Low

459890

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

High-throughput

0.249

Low

459901

PAQR2
Adiponectin receptor protein 2

1

0

Small-scale

0.249

Low

459927

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

459905

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025