Protein: AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase (Alpha-AASA dehydrogenase) (EC 1.2.1.31) (Aldehyde dehydrogenase family 7 member A1) (EC 1.2.1.3) (Antiquitin-1) (Betaine aldehyde dehydrogenase) (EC 1.2.1.8) (Delta1-piperideine-6-carboxylate dehydrogenase) (P6c dehydrogenase)

Gene: AL7A1, ALDH7A1
Organism: Homo sapiens
Interactions: 150
UniProt ID: P49419

Gene Ontology (top 5):
GO:0004029 - aldehyde dehydrogenase (NAD+) activity
GO:0004043 - L-aminoadipate-semialdehyde dehydrogenase activity
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

883073

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

2

14

High-throughput

0.783

High

883092

XRCC4
DNA repair protein XRCC4

3

0

High-throughput

0.638

High

883089

EPS8
Epidermal growth factor receptor kinase substrate 8

2

0

Small-scale

0.605

High

883137

ERP44
Endoplasmic reticulum resident protein 44

2

1

High-throughput

0.601

High

883084

NGAL
Neutrophil gelatinase-associated lipocalin

2

0

High-throughput

0.580

High

281296

GGYF1
GRB10-interacting GYF protein 1

1

2

High-throughput

0.536

High

773447

COPB2
Coatomer subunit beta'

1

6

High-throughput

0.536

High

883078

COPA
Coatomer subunit alpha

1

6

High-throughput

0.536

High

883082

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.536

High

883108

LDH6A
L-lactate dehydrogenase A-like 6A

1

2

High-throughput

0.536

High

883122

MK15
Mitogen-activated protein kinase 15

1

1

High-throughput

0.536

High

883144

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

1

High-throughput

0.536

High

883095

EMC2
ER membrane protein complex subunit 2

2

4

High-throughput

0.521

High

420427

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

High-throughput

0.515

High

774205

BASI
Basigin

1

4

High-throughput

0.515

High

122731

KIF2A
Kinesin-like protein KIF2A

1

0

High-throughput

0.513

High

158148

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.513

High

335792

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

0

High-throughput

0.513

High

361165

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

503561

TFPT
TCF3 fusion partner

1

0

High-throughput

0.513

High

883124

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

0

High-throughput

0.513

High

883135

SIKE1
Suppressor of IKBKE 1

1

0

High-throughput

0.513

High

185518

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

4

High-throughput

0.501

High

421713

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

883118

DOCK8
Dedicator of cytokinesis protein 8

1

0

High-throughput

0.493

High

883152

MYG1
MYG1 exonuclease

1

0

High-throughput

0.493

High

883140

DDA1
DET1- and DDB1-associated protein 1

1

1

High-throughput

0.489

High

241071

PRKN
E3 ubiquitin-protein ligase parkin

1

9

High-throughput

0.479

High

279698

CISY
Citrate synthase, mitochondrial

1

2

High-throughput

0.479

High

315279

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

371461

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

470923

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

5

High-throughput

0.479

High

487080

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

588183

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

694905

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

765246

BMI1
Polycomb complex protein BMI-1

1

1

Small-scale

0.479

High

873719

GSH0
Glutamate--cysteine ligase regulatory subunit

1

1

High-throughput

0.479

High

883081

WDR5
WD repeat-containing protein 5

1

3

High-throughput

0.479

High

883091

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

5

High-throughput

0.479

High

883093

CUL4A
Cullin-4A

1

4

High-throughput

0.479

High

883098

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

883103

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

3

High-throughput

0.479

High

883119

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

883126

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

883127

CSN5
COP9 signalosome complex subunit 5

1

6

High-throughput

0.479

High

883134

BAG1
BAG family molecular chaperone regulator 1

1

2

High-throughput

0.479

High

883143

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

6

High-throughput

0.479

High

883154

ZFYV1
Zinc finger FYVE domain-containing protein 1

1

1

Small-scale

0.479

High

883162

WWOX
WW domain-containing oxidoreductase

1

2

High-throughput

0.479

High

883165

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

362968

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

536744

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

883146

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

316265

RECQ5
ATP-dependent DNA helicase Q5

1

2

High-throughput

0.457

High

48560

ESYT2
Extended synaptotagmin-2

1

1

High-throughput

0.445

High

296460

STAM2
Signal transducing adapter molecule 2

1

1

High-throughput

0.445

High

359946

NB5R3
NADH-cytochrome b5 reductase 3

1

1

High-throughput

0.445

High

429519

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

529337

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.445

High

534786

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.445

High

593578

GDC
Solute carrier family 25 member 16

1

1

High-throughput

0.445

High

653192

HEMH
Ferrochelatase, mitochondrial

1

3

High-throughput

0.445

High

697805

CALR
Calreticulin

1

2

High-throughput

0.445

High

698488

CALX
Calnexin

1

2

High-throughput

0.445

High

876770

KC1A
Casein kinase I isoform alpha

1

1

High-throughput

0.445

High

883079

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.445

High

883083

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

3

High-throughput

0.445

High

883086

ARF5
ADP-ribosylation factor 5

1

2

High-throughput

0.445

High

883090

PRDX4
Peroxiredoxin-4

1

1

High-throughput

0.445

High

883105

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

8

High-throughput

0.445

High

883109

NBEL2
Neurobeachin-like protein 2

1

3

High-throughput

0.445

High

883111

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

1

High-throughput

0.445

High

883112

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

1

High-throughput

0.445

High

883115

DHB11
Estradiol 17-beta-dehydrogenase 11

1

3

High-throughput

0.445

High

883123

SCFD1
Sec1 family domain-containing protein 1

1

1

High-throughput

0.445

High

883131

SCYL1
N-terminal kinase-like protein

1

1

High-throughput

0.445

High

883141

WDR11
WD repeat-containing protein 11

1

1

High-throughput

0.445

High

883145

RGAP1
Rac GTPase-activating protein 1

1

1

High-throughput

0.445

High

883163

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.445

High

883164

COPG2
Coatomer subunit gamma-2

1

1

High-throughput

0.445

High

883169

COPG1
Coatomer subunit gamma-1

1

1

High-throughput

0.445

High

105564

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

767680

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

883106

RC3H1
Roquin-1

1

1

Small-scale

0.437

High

883110

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

883150

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.437

High

883151

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

883153

RC3H2
Roquin-2

1

1

Small-scale

0.437

High

60309

NBAS
NBAS subunit of NRZ tethering complex

1

0

High-throughput

0.426

High

211752

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

High-throughput

0.426

High

213577

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

0

High-throughput

0.426

High

318961

MICA2
[F-actin]-monooxygenase MICAL2

1

0

High-throughput

0.426

High

462294

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

0

High-throughput

0.426

High

566937

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.426

High

873177

COPD
Coatomer subunit delta

1

0

High-throughput

0.426

High

883075

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.426

High

883076

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.426

High

883077

COPB
Coatomer subunit beta

1

0

High-throughput

0.426

High

883080

COPZ1
Coatomer subunit zeta-1

1

0

High-throughput

0.426

High

883085

NUCB2
Nucleobindin-2

1

0

High-throughput

0.426

High

883094

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.426

High

883096

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

High-throughput

0.426

High

883097

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

High-throughput

0.426

High

883101

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.426

High

883107

LCLT1
Lysocardiolipin acyltransferase 1

1

0

High-throughput

0.426

High

883116

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.426

High

883117

VP37A
Vacuolar protein sorting-associated protein 37A

1

0

High-throughput

0.426

High

883129

ASTRA
Protein Aster-A

1

0

High-throughput

0.426

High

883133

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

883147

S2532
Solute carrier family 25 member 32

1

0

High-throughput

0.426

High

883148

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

High-throughput

0.426

High

883158

TM38B
Trimeric intracellular cation channel type B

1

0

High-throughput

0.426

High

883159

GPTC2
G patch domain-containing protein 2

1

0

High-throughput

0.426

High

883161

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.426

High

883168

SERC
Phosphoserine aminotransferase

1

0

High-throughput

0.426

High

50517

HACL2
2-hydroxyacyl-CoA lyase 2

1

3

High-throughput

0.407

High

104324

F5H6I7
Atlastin GTPase 3

1

3

High-throughput

0.407

High

275497

RTN2
Reticulon-2

1

2

High-throughput

0.407

High

328876

RTN3
Reticulon-3

1

2

High-throughput

0.407

High

332916

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.407

High

883074

TMEDA
Transmembrane emp24 domain-containing protein 10

1

2

High-throughput

0.407

High

883100

TMED2
Transmembrane emp24 domain-containing protein 2

1

2

High-throughput

0.407

High

883102

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

2

High-throughput

0.407

High

883104

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

3

High-throughput

0.407

High

883120

ATLA2
Atlastin-2

1

3

High-throughput

0.407

High

883125

ATLA1
Atlastin-1

1

3

High-throughput

0.407

High

883138

ESYT1
Extended synaptotagmin-1

1

2

High-throughput

0.407

High

883142

LNP
Endoplasmic reticulum junction formation protein lunapark

1

1

High-throughput

0.407

High

883149

TMX1
Thioredoxin-related transmembrane protein 1

1

1

High-throughput

0.407

High

883156

RTN4
Reticulon-4

1

2

High-throughput

0.407

High

883166

DHRS7
Dehydrogenase/reductase SDR family member 7

1

2

High-throughput

0.407

High

883167

TMED5
Transmembrane emp24 domain-containing protein 5

1

2

High-throughput

0.407

High

883130

T3HPD
Trans-3-hydroxy-L-proline dehydratase

2

0

High-throughput

0.318

High

883114

EMC1
ER membrane protein complex subunit 1

2

0

High-throughput

0.298

High

883132

PKNX2
Homeobox protein PKNOX2

1

0

High-throughput

0.279

Low

370171

CYTN
Cystatin-SN

1

0

Small-scale

0.249

Low

883088

CAC1B
Voltage-dependent N-type calcium channel subunit alpha-1B

1

0

High-throughput

0.249

Low

215513

EMC8
ER membrane protein complex subunit 8

1

0

High-throughput

0.232

Low

283216

ERLN1
Erlin-1

1

0

High-throughput

0.232

Low

883087

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.232

Low

883099

RCN1
Reticulocalbin-1

1

0

High-throughput

0.232

Low

883113

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.232

Low

883121

MCFD2
Multiple coagulation factor deficiency protein 2

1

0

High-throughput

0.232

Low

883128

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.232

Low

883136

PXL2A
Peroxiredoxin-like 2A

1

0

High-throughput

0.232

Low

883139

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.232

Low

883155

APMAP
Adipocyte plasma membrane-associated protein

1

0

High-throughput

0.232

Low

883157

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.232

Low

883160

PSD3
PH and SEC7 domain-containing protein 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025