Protein: MESH1
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (MESH1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) ((ppGpp)ase)

Gene: MESH1, HDDC3
Organism: Homo sapiens
Interactions: 52
UniProt ID: Q8N4P3

Gene Ontology (top 5):
GO:0008893 - guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
GO:0046872 - metal ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

138855

STK25
Serine/threonine-protein kinase 25

1

1

High-throughput

0.536

High

719986

HMOX2
Heme oxygenase 2

1

0

High-throughput

0.513

High

1326687

VRK1
Serine/threonine-protein kinase VRK1

1

1

High-throughput

0.489

High

1326698

TLN1
Talin-1

1

1

High-throughput

0.489

High

1218093

Q5VU62
TPM3 protein

1

1

High-throughput

0.470

High

1245288

Q6PJH3
A kinase

1

1

High-throughput

0.470

High

447809

TPM3
Tropomyosin alpha-3 chain

1

1

High-throughput

0.439

High

1326688

AKAP9
A-kinase anchor protein 9

1

1

High-throughput

0.439

High

1101227

NMI
N-myc-interactor

4

0

High-throughput

0.368

High

1326695

WRP73
WD repeat-containing protein WRAP73

4

0

High-throughput

0.360

High

1137855

TNIP1
TNFAIP3-interacting protein 1

2

0

High-throughput

0.335

High

505671

CC172
Coiled-coil domain-containing protein 172

2

0

High-throughput

0.327

High

848338

MAGA4
Melanoma-associated antigen 4

2

0

High-throughput

0.316

High

1326682

CCHCR
Coiled-coil alpha-helical rod protein 1

2

0

High-throughput

0.316

High

1326690

MSTO1
Protein misato homolog 1

2

0

High-throughput

0.316

High

137252

EXOC5
Exocyst complex component 5

1

0

High-throughput

0.299

High

1217437

GKAP1
G kinase-anchoring protein 1

1

0

High-throughput

0.299

High

1315757

CE57L
Centrosomal protein CEP57L1

1

0

High-throughput

0.299

High

564050

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.282

High

49329

SHOT1
Shootin-1

1

0

High-throughput

0.279

Low

62984

POTEF
POTE ankyrin domain family member F

1

0

High-throughput

0.279

Low

208310

RRP8
Ribosomal RNA-processing protein 8

1

0

High-throughput

0.279

Low

290630

SURF6
Surfeit locus protein 6

1

0

High-throughput

0.279

Low

354361

TOM40
Mitochondrial import receptor subunit TOM40 homolog

1

0

High-throughput

0.279

Low

360036

NB5R3
NADH-cytochrome b5 reductase 3

1

0

High-throughput

0.279

Low

631340

RAB5A
Ras-related protein Rab-5A

1

0

High-throughput

0.279

Low

912792

AGFG1
Arf-GAP domain and FG repeat-containing protein 1

1

0

High-throughput

0.279

Low

922465

CLH2
Clathrin heavy chain 2

1

0

High-throughput

0.279

Low

962264

RHOA
Transforming protein RhoA

1

0

High-throughput

0.279

Low

1091778

PP1R8
Nuclear inhibitor of protein phosphatase 1

1

0

High-throughput

0.279

Low

1092332

CSTF3
Cleavage stimulation factor subunit 3

1

0

High-throughput

0.279

Low

1116966

CD166
CD166 antigen

1

0

High-throughput

0.279

Low

1130103

SMC1A
Structural maintenance of chromosomes protein 1A

1

0

High-throughput

0.279

Low

1143638

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.279

Low

1156544

CCDC6
Coiled-coil domain-containing protein 6

1

0

High-throughput

0.279

Low

1177601

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

0

High-throughput

0.279

Low

1278760

HDGR2
Hepatoma-derived growth factor-related protein 2

1

0

High-throughput

0.279

Low

1326681

F133A
Protein FAM133A

1

0

High-throughput

0.279

Low

1326683

ARL8A
ADP-ribosylation factor-like protein 8A

1

0

High-throughput

0.279

Low

1326684

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

1

0

High-throughput

0.279

Low

1326685

CAR19
Caspase recruitment domain-containing protein 19

1

0

High-throughput

0.279

Low

1326686

S29A1
Equilibrative nucleoside transporter 1

1

0

High-throughput

0.279

Low

1326689

CND3
Condensin complex subunit 3

1

0

High-throughput

0.279

Low

1326691

ZY11B
Protein zyg-11 homolog B

1

0

High-throughput

0.279

Low

1326692

PAAT
ATPase PAAT

1

0

High-throughput

0.279

Low

1326693

E41L5
Band 4.1-like protein 5

1

0

High-throughput

0.279

Low

1326694

EHD3
EH domain-containing protein 3

1

0

High-throughput

0.279

Low

1326696

DBNL
Drebrin-like protein

1

0

High-throughput

0.279

Low

1326697

AP3M1
AP-3 complex subunit mu-1

1

0

High-throughput

0.279

Low

1068823

GOG8D
Putative golgin subfamily A member 8D

1

0

High-throughput

0.268

Low

422577

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.261

Low

260178

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025