Protein: TOM40
Mitochondrial import receptor subunit TOM40 homolog (Protein Haymaker) (Translocase of outer membrane 40 kDa subunit homolog) (p38.5)

Gene: TOM40, TOMM40
Organism: Homo sapiens
Interactions: 184
UniProt ID: O96008

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005742 - mitochondrial outer membrane translocase complex
GO:0005743 - mitochondrial inner membrane
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

354410

TOM22
Mitochondrial import receptor subunit TOM22 homolog

6

2

Small-scale

0.943

High

354425

SAM50
Sorting and assembly machinery component 50 homolog

2

2

Small-scale

0.768

High

354338

TOM20
Mitochondrial import receptor subunit TOM20 homolog

5

6

Small-scale

0.709

High

354374

TOM6
Mitochondrial import receptor subunit TOM6 homolog

1

1

High-throughput

0.691

High

354391

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

4

4

Small-scale

0.686

High

240413

PRKN
E3 ubiquitin-protein ligase parkin

3

6

Small-scale

0.651

High

354333

MTX1
Metaxin-1

1

4

Small-scale

0.647

High

348296

AIFM1
Apoptosis-inducing factor 1, mitochondrial

3

3

High-throughput

0.643

High

354415

MIC19
MICOS complex subunit MIC19

2

2

High-throughput

0.628

High

354421

TOM7
Mitochondrial import receptor subunit TOM7 homolog

1

2

Small-scale

0.618

High

317967

TOM70
Mitochondrial import receptor subunit TOM70

2

5

Small-scale

0.611

High

354306

RAB7A
Ras-related protein Rab-7a

2

12

Small-scale

0.611

High

354376

OPTN
Optineurin

2

3

High-throughput

0.611

High

354367

SFXN5
Sideroflexin-5

2

2

High-throughput

0.601

High

354379

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

2

2

High-throughput

0.601

High

354399

TRABD
TraB domain-containing protein

2

0

High-throughput

0.585

High

354332

SQSTM
Sequestosome-1

2

2

Small-scale

0.584

High

354413

OCAD1
OCIA domain-containing protein 1

2

2

High-throughput

0.584

High

354419

KLRF1
Killer cell lectin-like receptor subfamily F member 1

2

7

High-throughput

0.584

High

354348

NR3L1
Natural cytotoxicity triggering receptor 3 ligand 1

2

1

High-throughput

0.574

High

354357

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

2

2

High-throughput

0.574

High

354283

ESR1
Estrogen receptor

2

7

High-throughput

0.571

High

354427

MTCH2
Mitochondrial carrier homolog 2

2

10

High-throughput

0.571

High

354387

RHG09
Rho GTPase-activating protein 9

2

0

High-throughput

0.547

High

66416

ASB14
Ankyrin repeat and SOCS box protein 14

1

3

High-throughput

0.536

High

244832

TRAK2
Trafficking kinesin-binding protein 2

1

5

High-throughput

0.536

High

336814

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

2

High-throughput

0.536

High

354281

NB5R3
NADH-cytochrome b5 reductase 3

1

3

High-throughput

0.536

High

354285

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.536

High

354287

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

4

High-throughput

0.536

High

354288

TAU
Microtubule-associated protein tau

1

12

High-throughput

0.536

High

354295

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

2

High-throughput

0.536

High

354303

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

354314

RAB2A
Ras-related protein Rab-2A

1

14

High-throughput

0.536

High

354315

RAB10
Ras-related protein Rab-10

1

9

High-throughput

0.536

High

354316

RAB14
Ras-related protein Rab-14

1

15

High-throughput

0.536

High

354319

RAB1A
Ras-related protein Rab-1A

1

11

High-throughput

0.536

High

354325

TAP1
Antigen peptide transporter 1

1

4

High-throughput

0.536

High

354334

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

7

High-throughput

0.536

High

354337

RAB35
Ras-related protein Rab-35

1

9

High-throughput

0.536

High

354342

MIC60
MICOS complex subunit MIC60

1

2

High-throughput

0.536

High

354360

S35F6
Solute carrier family 35 member F6

1

6

High-throughput

0.536

High

354395

RAB1B
Ras-related protein Rab-1B

1

9

High-throughput

0.536

High

354397

SRMS
Tyrosine-protein kinase Srms

1

1

High-throughput

0.536

High

354400

MTG2
Mitochondrial ribosome-associated GTPase 2

1

8

High-throughput

0.536

High

354424

CHIP
E3 ubiquitin-protein ligase CHIP

1

5

High-throughput

0.536

High

354351

SCMC1
Mitochondrial adenyl nucleotide antiporter SLC25A24

1

6

High-throughput

0.515

High

137369

BT3A3
Butyrophilin subfamily 3 member A3

1

0

High-throughput

0.513

High

269721

CAPON
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

1

0

High-throughput

0.513

High

328341

NDUB8
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

1

0

High-throughput

0.513

High

334365

SYFM
Phenylalanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

346788

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

354297

LAMA1
Laminin subunit alpha-1

1

0

High-throughput

0.513

High

354311

ATP5I
ATP synthase F(0) complex subunit e, mitochondrial

1

0

High-throughput

0.513

High

354320

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

1

0

High-throughput

0.513

High

354388

URM1
Ubiquitin-related modifier 1

1

0

High-throughput

0.513

High

354411

F217B
Protein FAM217B

1

0

High-throughput

0.513

High

354429

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.513

High

354430

CEPT1
Choline/ethanolaminephosphotransferase 1

1

0

High-throughput

0.513

High

354286

HS90A
Heat shock protein HSP 90-alpha

1

7

Small-scale

0.501

High

354299

HSP74
Heat shock 70 kDa protein 4

1

4

Small-scale

0.501

High

354310

FOXA3
Hepatocyte nuclear factor 3-gamma

1

4

High-throughput

0.489

High

354324

ECT2L
Epithelial cell-transforming sequence 2 oncogene-like

1

6

High-throughput

0.489

High

354327

FOXF2
Forkhead box protein F2

1

4

High-throughput

0.489

High

354328

FOXI1
Forkhead box protein I1

1

3

High-throughput

0.489

High

354329

FOXL1
Forkhead box protein L1

1

4

High-throughput

0.489

High

354341

RTN1
Reticulon-1

1

1

High-throughput

0.489

High

354359

PHAR4
Phosphatase and actin regulator 4

1

3

High-throughput

0.489

High

354363

UBAC2
Ubiquitin-associated domain-containing protein 2

1

1

High-throughput

0.489

High

354375

FAF2
FAS-associated factor 2

1

8

High-throughput

0.489

High

354380

TECTB
Beta-tectorin

1

2

High-throughput

0.489

High

354382

FOXB1
Forkhead box protein B1

1

5

High-throughput

0.489

High

354384

RNF5
E3 ubiquitin-protein ligase RNF5

1

2

High-throughput

0.489

High

354396

TMPS5
Transmembrane protease serine 5

1

10

High-throughput

0.489

High

354420

FOXJ2
Forkhead box protein J2

1

5

High-throughput

0.489

High

354381

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

Small-scale

0.480

High

125121

LEG9
Galectin-9

1

1

High-throughput

0.479

High

126424

RHOD
Rho-related GTP-binding protein RhoD

1

9

High-throughput

0.479

High

156815

CTRO
Citron Rho-interacting kinase

1

6

High-throughput

0.479

High

166839

MGST3
Glutathione S-transferase 3, mitochondrial

1

2

High-throughput

0.479

High

180978

LRAD4
Low-density lipoprotein receptor class A domain-containing protein 4

1

1

High-throughput

0.479

High

222619

PRC1
Protein regulator of cytokinesis 1

1

3

High-throughput

0.479

High

245399

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

2

High-throughput

0.479

High

292050

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

6

High-throughput

0.479

High

319267

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

337543

FMNL1
Formin-like protein 1

1

1

Small-scale

0.479

High

354282

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

2

High-throughput

0.479

High

354284

HSPB1
Heat shock protein beta-1

1

2

Small-scale

0.479

High

354290

RAC2
Ras-related C3 botulinum toxin substrate 2

1

5

High-throughput

0.479

High

354301

COIL
Coilin

1

2

High-throughput

0.479

High

354307

BAP31
B-cell receptor-associated protein 31

1

3

Small-scale

0.479

High

354309

RND2
Rho-related GTP-binding protein RhoN

1

15

High-throughput

0.479

High

354313

CDC42
Cell division control protein 42 homolog

1

6

High-throughput

0.479

High

354317

RHOA
Transforming protein RhoA

1

7

High-throughput

0.479

High

354318

RHOB
Rho-related GTP-binding protein RhoB

1

7

High-throughput

0.479

High

354321

RAC1
Ras-related C3 botulinum toxin substrate 1

1

6

High-throughput

0.479

High

354322

RHOG
Rho-related GTP-binding protein RhoG

1

5

High-throughput

0.479

High

354323

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

354326

BAX
Apoptosis regulator BAX

1

8

Small-scale

0.479

High

354331

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

354345

MIDN
Midnolin

1

3

High-throughput

0.479

High

354347

OTU1
Ubiquitin thioesterase OTU1

1

1

High-throughput

0.479

High

354354

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

1

6

Small-scale

0.479

High

354356

ZN598
E3 ubiquitin-protein ligase ZNF598

1

3

High-throughput

0.479

High

354369

AKAP1
A-kinase anchor protein 1, mitochondrial

1

3

High-throughput

0.479

High

354370

FBXW7
F-box/WD repeat-containing protein 7

1

3

Small-scale

0.479

High

354372

S2546
Mitochondrial outer membrane protein SLC25A46

1

1

Small-scale

0.479

High

354394

TOLIP
Toll-interacting protein

1

1

High-throughput

0.479

High

354402

DUS21
Dual specificity protein phosphatase 21

1

1

High-throughput

0.479

High

354403

RHOF
Rho-related GTP-binding protein RhoF

1

8

High-throughput

0.479

High

354405

NMRL1
NmrA-like family domain-containing protein 1

1

2

High-throughput

0.479

High

354407

ANLN
Anillin

1

3

High-throughput

0.479

High

354409

DUS22
Dual specificity protein phosphatase 22

1

1

High-throughput

0.479

High

354414

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

1

Small-scale

0.479

High

354418

MTCH1
Mitochondrial carrier homolog 1

1

7

High-throughput

0.479

High

354423

PKHG1
Pleckstrin homology domain-containing family G member 1

1

4

High-throughput

0.479

High

354422

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

1

High-throughput

0.470

High

137606

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

274959

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

354305

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.458

High

354364

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

354365

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

354383

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

354404

PLRKT
Plasminogen receptor

1

0

High-throughput

0.458

High

354408

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

354417

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

871

SIM26
Small integral membrane protein 26

1

2

High-throughput

0.445

High

190183

MOT4
Monocarboxylate transporter 4

1

7

High-throughput

0.445

High

354296

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.445

High

354308

SUOX
Sulfite oxidase, mitochondrial

1

1

High-throughput

0.445

High

354336

MFS10
Major facilitator superfamily domain-containing protein 10

1

7

High-throughput

0.445

High

354344

Q4KN05
KLRF1 protein

1

1

High-throughput

0.445

High

354346

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.445

High

354350

PKHA7
Pleckstrin homology domain-containing family A member 7

1

13

High-throughput

0.445

High

354358

DND1
Dead end protein homolog 1

1

3

High-throughput

0.445

High

354366

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

10

High-throughput

0.445

High

354377

SYMM
Methionine--tRNA ligase, mitochondrial

1

2

High-throughput

0.445

High

354428

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

2

High-throughput

0.445

High

212895

LRRT2
Leucine-rich repeat transmembrane neuronal protein 2

1

1

High-throughput

0.437

High

318554

RHBT1
Rho-related BTB domain-containing protein 1

1

15

High-throughput

0.437

High

330549

KI20A
Kinesin-like protein KIF20A

1

9

High-throughput

0.437

High

332610

LYPD3
Ly6/PLAUR domain-containing protein 3

1

1

High-throughput

0.437

High

352810

AGR2
Anterior gradient protein 2 homolog

1

3

High-throughput

0.437

High

354291

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

354292

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.437

High

354298

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

354300

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

354304

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.437

High

354330

SLAF1
Signaling lymphocytic activation molecule

1

2

High-throughput

0.437

High

354339

RHOH
Rho-related GTP-binding protein RhoH

1

11

High-throughput

0.437

High

354353

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

354362

FBXL6
F-box/LRR-repeat protein 6

1

6

High-throughput

0.437

High

354378

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.437

High

354393

SPRTN
DNA-dependent metalloprotease SPRTN

1

3

High-throughput

0.437

High

354398

RHOJ
Rho-related GTP-binding protein RhoJ

1

7

High-throughput

0.437

High

354401

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.437

High

248823

GSDME
Gasdermin-E

1

0

High-throughput

0.426

High

354371

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.426

High

354386

RNZ2
Zinc phosphodiesterase ELAC protein 2

1

0

High-throughput

0.426

High

354392

NMNA2
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2

1

0

High-throughput

0.426

High

354412

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

354416

SCN3B
Sodium channel regulatory subunit beta-3

1

0

High-throughput

0.426

High

354312

WNT4
Protein Wnt-4

3

0

High-throughput

0.339

High

354289

CP2C9
Cytochrome P450 2C9

2

0

High-throughput

0.328

High

63740

KRBA1
Protein KRBA1

2

0

High-throughput

0.313

High

354343

ATG2A
Autophagy-related protein 2 homolog A

1

0

Small-scale

0.289

High

230735

EXTL3
Exostosin-like 3

1

0

High-throughput

0.279

Low

253804

TPST2
Protein-tyrosine sulfotransferase 2

1

0

High-throughput

0.279

Low

354293

EGLN
Endoglin

1

0

High-throughput

0.279

Low

354294

ITIH1
Inter-alpha-trypsin inhibitor heavy chain H1

1

0

High-throughput

0.279

Low

354302

GPV
Platelet glycoprotein V

1

0

High-throughput

0.279

Low

354335

ZN460
Zinc finger protein 460

1

0

High-throughput

0.279

Low

354355

GOGA7
Golgin subfamily A member 7

1

0

High-throughput

0.279

Low

354361

MESH1
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

1

0

High-throughput

0.279

Low

354385

F118B
Protein FAM118B

1

0

High-throughput

0.279

Low

354389

TBB6
Tubulin beta-6 chain

1

0

High-throughput

0.279

Low

354390

YJU2
Splicing factor YJU2

1

0

High-throughput

0.279

Low

354406

SAYS1
SAYSvFN domain-containing protein 1

1

0

High-throughput

0.279

Low

354426

WIF1
Wnt inhibitory factor 1

1

0

High-throughput

0.279

Low

354340

E2F4
Transcription factor E2F4

1

0

High-throughput

0.249

Low

354349

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

354373

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low

354352

SHLD3
Shieldin complex subunit 3

1

0

High-throughput

0.232

Low

354368

Q8TE30
RNA-directed DNA polymerase

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025