Protein: TM223
Transmembrane protein 223

Gene: TM223, TMEM223
Organism: Homo sapiens
Interactions: 72
UniProt ID: A0PJW6

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0033617 - mitochondrial cytochrome c oxidase assembly
GO:0097177 - mitochondrial ribosome binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

49440

ATP7B
Copper-transporting ATPase 2

2

1

High-throughput

0.628

High

49484

PCDC2
Protocadherin alpha-C2

3

5

High-throughput

0.604

High

49435

KCNA5
Potassium voltage-gated channel subfamily A member 5

2

1

High-throughput

0.574

High

49438

ACHA3
Neuronal acetylcholine receptor subunit alpha-3

2

1

High-throughput

0.574

High

49444

AT12A
Potassium-transporting ATPase alpha chain 2

2

1

High-throughput

0.574

High

49477

PCDA4
Protocadherin alpha-4

2

5

High-throughput

0.574

High

49461

5HT3C
5-hydroxytryptamine receptor 3C

2

3

High-throughput

0.558

High

49413

KCNK1
Potassium channel subfamily K member 1

1

1

High-throughput

0.489

High

49414

UPK1A
Uroplakin-1a

1

1

High-throughput

0.489

High

49422

5HT3B
5-hydroxytryptamine receptor 3B

1

3

High-throughput

0.489

High

49424

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

2

High-throughput

0.489

High

49425

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

2

High-throughput

0.489

High

49432

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

1

High-throughput

0.489

High

49433

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

1

High-throughput

0.489

High

49442

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

1

High-throughput

0.489

High

49453

KCNKI
Potassium channel subfamily K member 18

1

1

High-throughput

0.489

High

49465

CREL1
Protein disulfide isomerase CRELD1

1

1

High-throughput

0.489

High

49474

PCD10
Protocadherin-10

1

5

High-throughput

0.489

High

49482

PCDG9
Protocadherin gamma-A9

1

4

High-throughput

0.489

High

49483

PCDA8
Protocadherin alpha-8

1

5

High-throughput

0.489

High

49448

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.458

High

49458

S2540
Mitochondrial glutathione transporter SLC25A40

1

0

High-throughput

0.426

High

49473

ATD3A
ATPase family AAA domain-containing protein 3A

1

0

High-throughput

0.426

High

49480

COA3
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial

1

0

Small-scale

0.426

High

49481

PCDGH
Protocadherin gamma-B5

1

5

High-throughput

0.407

High

49431

HLAC
HLA class I histocompatibility antigen, C alpha chain

3

0

High-throughput

0.347

High

49479

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

3

0

High-throughput

0.347

High

49446

TRDN
Triadin

3

0

High-throughput

0.345

High

49450

KLH22
Kelch-like protein 22

3

0

High-throughput

0.345

High

49417

TR10B
Tumor necrosis factor receptor superfamily member 10B

2

0

High-throughput

0.328

High

49429

NEP
Neprilysin

2

0

High-throughput

0.328

High

49437

CTR1
High affinity cationic amino acid transporter 1

2

0

High-throughput

0.328

High

49439

CGL
Cystathionine gamma-lyase

2

0

High-throughput

0.328

High

49441

MTHR
Methylenetetrahydrofolate reductase

2

0

High-throughput

0.328

High

49443

AGRE5
Adhesion G protein-coupled receptor E5

2

0

High-throughput

0.328

High

49451

TTMP
TPA-induced transmembrane protein

2

0

High-throughput

0.328

High

49452

S39A5
Zinc transporter ZIP5

2

0

High-throughput

0.328

High

49472

IPPK
Inositol-pentakisphosphate 2-kinase

2

0

High-throughput

0.328

High

49462

LPAR1
Lysophosphatidic acid receptor 1

2

0

High-throughput

0.313

High

49470

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

2

0

High-throughput

0.305

High

49457

TOIP2
Torsin-1A-interacting protein 2

2

0

High-throughput

0.288

High

49415

SDCB1
Syntenin-1

1

0

High-throughput

0.279

Low

49416

ACKR2
Atypical chemokine receptor 2

1

0

High-throughput

0.279

Low

49423

TSN15
Tetraspanin-15

1

0

High-throughput

0.279

Low

49426

RET4
Retinol-binding protein 4

1

0

High-throughput

0.279

Low

49434

NAGAB
Alpha-N-acetylgalactosaminidase

1

0

High-throughput

0.279

Low

49436

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

0

High-throughput

0.279

Low

49445

TM258
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258

1

0

High-throughput

0.279

Low

49447

PDCD1
Programmed cell death protein 1

1

0

High-throughput

0.279

Low

49454

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

1

0

High-throughput

0.279

Low

49455

AMGO1
Amphoterin-induced protein 1

1

0

High-throughput

0.279

Low

49464

BSCL2
Seipin

1

0

High-throughput

0.279

Low

49467

TLR10
Toll-like receptor 10

1

0

High-throughput

0.279

Low

49468

YIPF3
Protein YIPF3

1

0

High-throughput

0.279

Low

49469

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.279

Low

49475

RBM27
RNA-binding protein 27

1

0

High-throughput

0.279

Low

49449

MBRL
Membralin

1

0

High-throughput

0.269

Low

49430

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.261

Low

49418

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.249

Low

49421

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

49460

DUS19
Dual specificity protein phosphatase 19

1

0

High-throughput

0.249

Low

49471

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

49419

S19A2
Thiamine transporter 1

1

0

High-throughput

0.232

Low

49420

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.232

Low

49427

FRIL
Ferritin light chain

1

0

High-throughput

0.232

Low

49428

SYPH
Synaptophysin

1

0

High-throughput

0.232

Low

49456

S35F3
Solute carrier family 35 member F3

1

0

High-throughput

0.232

Low

49459

TBC15
TBC1 domain family member 15

1

0

High-throughput

0.232

Low

49463

SAAL1
Protein SAAL1

1

0

High-throughput

0.232

Low

49466

TCAB1
Telomerase Cajal body protein 1

1

0

High-throughput

0.232

Low

49476

RHCG
Ammonium transporter Rh type C

1

0

High-throughput

0.232

Low

49478

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025