Protein: MED27
Mediator of RNA polymerase II transcription subunit 27 (Mediator complex subunit 27) (dCRSP34) (dMED27) (dTRAP37)

Gene: MED27
Organism: Drosophila melanogaster
Interactions: 66
UniProt ID: Q9VNG0

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0016592 - mediator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1019294

MED20
Mediator of RNA polymerase II transcription subunit 20

2

1

High-throughput

0.737

High

58502

MED8
Mediator of RNA polymerase II transcription subunit 8

2

1

High-throughput

0.571

High

1267064

MED29
Mediator of RNA polymerase II transcription subunit 29

2

1

High-throughput

0.571

High

1321570

MED6
Mediator of RNA polymerase II transcription subunit 6

2

1

High-throughput

0.571

High

1377791

EBI
F-box-like/WD repeat-containing protein ebi

2

1

High-throughput

0.571

High

1427991

MED10
Mediator of RNA polymerase II transcription subunit 10

2

1

High-throughput

0.571

High

1428100

MED7
Mediator of RNA polymerase II transcription subunit 7

2

1

High-throughput

0.571

High

1472606

MED17
Mediator of RNA polymerase II transcription subunit 17

2

1

High-throughput

0.571

High

1473437

Q9VF03
Brahma associated protein 155 kDa

2

2

High-throughput

0.571

High

1482734

MED4
Mediator of RNA polymerase II transcription subunit 4

2

2

High-throughput

0.571

High

1482737

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

2

1

High-throughput

0.571

High

1482738

CDK8
Cyclin-dependent kinase 8

2

3

High-throughput

0.571

High

1482742

MED11
Mediator of RNA polymerase II transcription subunit 11

2

1

High-throughput

0.571

High

1482747

MED30
Mediator of RNA polymerase II transcription subunit 30

2

1

High-throughput

0.571

High

1482748

MED14
Mediator of RNA polymerase II transcription subunit 14

2

1

High-throughput

0.571

High

1482749

MED23
Mediator of RNA polymerase II transcription subunit 23

2

2

High-throughput

0.571

High

1482752

MED18
Mediator of RNA polymerase II transcription subunit 18

2

1

High-throughput

0.571

High

674051

BRM
ATP-dependent helicase brm

2

0

High-throughput

0.547

High

900665

DSH
Segment polarity protein dishevelled

2

0

High-throughput

0.547

High

1480260

Q9VL29
GEO11246p1

2

0

High-throughput

0.547

High

1482745

BAP60
Brahma-associated protein of 60 kDa

2

0

High-throughput

0.547

High

56998

A1ZAK9
P-element somatic inhibitor, isoform A

1

1

High-throughput

0.479

High

756500

ECR
Ecdysone receptor

1

3

Small-scale

0.479

High

1482753

MED15
Mediator of RNA polymerase II transcription subunit 15

1

1

High-throughput

0.479

High

1482733

Q9VR42
Serine/threonine-protein kinase RIO3

1

0

High-throughput

0.458

High

56955

A1ZAK7
LD35640p

1

1

High-throughput

0.445

High

1269626

MED13
Mediator of RNA polymerase II transcription subunit 13

1

2

High-throughput

0.445

High

1302891

MED31
Mediator of RNA polymerase II transcription subunit 31

1

1

High-throughput

0.445

High

1465338

MED22
Mediator of RNA polymerase II transcription subunit 22

1

1

High-throughput

0.445

High

1469498

MED28
Mediator of RNA polymerase II transcription subunit 28

1

1

High-throughput

0.445

High

1471833

MED25
Mediator of RNA polymerase II transcription subunit 25

1

1

High-throughput

0.445

High

1482731

MED1
Mediator of RNA polymerase II transcription subunit 1

1

1

High-throughput

0.445

High

1482736

MED24
Mediator of RNA polymerase II transcription subunit 24

1

1

High-throughput

0.445

High

1482741

MED19
Mediator of RNA polymerase II transcription subunit 19

1

1

High-throughput

0.445

High

1482743

MED12
Mediator of RNA polymerase II transcription subunit 12

1

2

High-throughput

0.445

High

1482750

MED16
Mediator of RNA polymerase II transcription subunit 16

1

1

High-throughput

0.445

High

1346345

FANCL
E3 ubiquitin-protein ligase Fancl

1

0

High-throughput

0.438

High

84983

B7Z126
non-specific serine/threonine protein kinase

1

0

High-throughput

0.426

High

197479

O18353
CHIP

1

0

High-throughput

0.426

High

1171910

Q24090
GH08712p

1

0

High-throughput

0.426

High

1261420

Q7JQT8
LD41464p

1

0

High-throughput

0.426

High

1263897

Q7K012
Brahma associated protein 55kD

1

0

High-throughput

0.426

High

1303623

OSA
Trithorax group protein osa

1

0

High-throughput

0.426

High

1306429

INDRA
Zinc finger protein indra

1

0

High-throughput

0.426

High

1343908

Q8SXP8
TAR DNA-binding protein 43

1

0

High-throughput

0.426

High

1409393

Q9BIW6
Brahma-associated protein 111kD

1

0

High-throughput

0.426

High

1472582

Q9VEB9
Sequence-specific single-stranded DNA-binding protein, isoform A

1

0

High-throughput

0.426

High

1482744

Q9VX77
Coiled-coil-helix-coiled-coil-helix domain containing 2, isoform A

1

0

High-throughput

0.426

High

1482751

Q9W3G1
Uncharacterized protein, isoform A

1

0

High-throughput

0.426

High

1321515

ENC
Protein encore

2

0

High-throughput

0.298

High

1346432

MESD
LDLR chaperone boca

2

0

High-throughput

0.298

High

1378930

Q960F7
SD03629p

2

0

High-throughput

0.298

High

1440691

LAR4
La-related protein Larp4B

2

0

High-throughput

0.298

High

1482740

Q9VUB7
PAX-interacting protein 1

2

0

High-throughput

0.298

High

1482732

CH60B
60 kDa heat shock protein homolog 1, mitochondrial

1

0

High-throughput

0.238

Low

84724

UNR
RNA-binding protein Unr

1

0

High-throughput

0.232

Low

1069269

Q0E8G6
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.232

Low

1069933

Q0E996
Eukaryotic translation initiation factor 4 gamma 2

1

0

High-throughput

0.232

Low

1265439

Q7K2P3
GH20817p

1

0

High-throughput

0.232

Low

1345935

Q8T4A8
AT07769p

1

0

High-throughput

0.232

Low

1346028

ENA
Protein enabled

1

0

High-throughput

0.232

Low

1378340

Q95TT5
LD24616p

1

0

High-throughput

0.232

Low

1482713

Q9VNF8
Protein transport protein SEC23

1

0

High-throughput

0.232

Low

1482735

Q9VSD3
AT11025p

1

0

High-throughput

0.232

Low

1482739

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

0

High-throughput

0.232

Low

1482746

Q9W0L7
ubiquitinyl hydrolase 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025