Protein: MED25
Mediator of RNA polymerase II transcription subunit 25 (Mediator complex subunit 25) (dmPTOV2)

Gene: MED25
Organism: Drosophila melanogaster
Interactions: 60
UniProt ID: Q9VDR1

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0005654 - nucleoplasm
GO:0005667 - transcription regulator complex
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0006963 - positive regulation of antibacterial peptide biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1471849

MED23
Mediator of RNA polymerase II transcription subunit 23

2

1

High-throughput

0.737

High

1471850

MED16
Mediator of RNA polymerase II transcription subunit 16

1

1

High-throughput

0.575

High

1377778

EBI
F-box-like/WD repeat-containing protein ebi

2

4

High-throughput

0.571

High

1471827

MED17
Mediator of RNA polymerase II transcription subunit 17

2

1

High-throughput

0.571

High

1471848

MED14
Mediator of RNA polymerase II transcription subunit 14

2

8

High-throughput

0.571

High

58493

MED8
Mediator of RNA polymerase II transcription subunit 8

2

0

High-throughput

0.547

High

1261410

Q7JQT8
LD41464p

2

0

High-throughput

0.547

High

900658

DSH
Segment polarity protein dishevelled

2

4

High-throughput

0.521

High

1471837

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

2

16

High-throughput

0.521

High

1471846

Q9W0L7
ubiquitinyl hydrolase 1

2

1

High-throughput

0.521

High

628540

USP
Protein ultraspiracle

1

20

Small-scale

0.479

High

1306726

Q8IRT8
non-specific serine/threonine protein kinase

1

1

High-throughput

0.479

High

674043

BRM
ATP-dependent helicase brm

1

11

High-throughput

0.445

High

1019289

MED20
Mediator of RNA polymerase II transcription subunit 20

1

1

High-throughput

0.445

High

1171891

Q24090
GH08712p

1

5

High-throughput

0.445

High

1267058

MED29
Mediator of RNA polymerase II transcription subunit 29

1

1

High-throughput

0.445

High

1269615

MED13
Mediator of RNA polymerase II transcription subunit 13

1

1

High-throughput

0.445

High

1302886

MED31
Mediator of RNA polymerase II transcription subunit 31

1

1

High-throughput

0.445

High

1303615

OSA
Trithorax group protein osa

1

12

High-throughput

0.445

High

1321557

MED6
Mediator of RNA polymerase II transcription subunit 6

1

2

High-throughput

0.445

High

1343896

Q8SXP8
TAR DNA-binding protein 43

1

2

High-throughput

0.445

High

1427980

MED10
Mediator of RNA polymerase II transcription subunit 10

1

2

High-throughput

0.445

High

1428092

MED7
Mediator of RNA polymerase II transcription subunit 7

1

1

High-throughput

0.445

High

1471826

Q9VEB9
Sequence-specific single-stranded DNA-binding protein, isoform A

1

3

High-throughput

0.445

High

1471828

Q9VF03
Brahma associated protein 155 kDa

1

14

High-throughput

0.445

High

1471829

PIWI
Protein piwi

1

3

High-throughput

0.445

High

1471833

MED27
Mediator of RNA polymerase II transcription subunit 27

1

1

High-throughput

0.445

High

1471834

MED1
Mediator of RNA polymerase II transcription subunit 1

1

3

High-throughput

0.445

High

1471835

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.445

High

1471836

MED24
Mediator of RNA polymerase II transcription subunit 24

1

1

High-throughput

0.445

High

1471838

CDK8
Cyclin-dependent kinase 8

1

6

High-throughput

0.445

High

1471839

Q9VUB7
PAX-interacting protein 1

1

7

High-throughput

0.445

High

1471840

MED19
Mediator of RNA polymerase II transcription subunit 19

1

1

High-throughput

0.445

High

1471841

MED11
Mediator of RNA polymerase II transcription subunit 11

1

1

High-throughput

0.445

High

1471842

MED12
Mediator of RNA polymerase II transcription subunit 12

1

19

High-throughput

0.445

High

1471844

BAP60
Brahma-associated protein of 60 kDa

1

11

High-throughput

0.445

High

1471847

MED30
Mediator of RNA polymerase II transcription subunit 30

1

1

High-throughput

0.445

High

1471851

Q9W3G1
Uncharacterized protein, isoform A

1

14

High-throughput

0.445

High

1471853

MED18
Mediator of RNA polymerase II transcription subunit 18

1

1

High-throughput

0.445

High

197469

O18353
CHIP

1

0

High-throughput

0.426

High

53584

A1Z813
Secretory 24AB, isoform A

1

7

High-throughput

0.407

High

56948

A1ZAK7
LD35640p

1

1

High-throughput

0.407

High

869138

TIS11
Protein TIS11

1

3

High-throughput

0.407

High

1321509

ENC
Protein encore

1

2

High-throughput

0.407

High

1346016

ENA
Protein enabled

1

10

High-throughput

0.407

High

1378334

Q95TT5
LD24616p

1

13

High-throughput

0.407

High

1378911

Q960F7
SD03629p

1

1

High-throughput

0.407

High

1409388

Q9BIW6
Brahma-associated protein 111kD

1

11

High-throughput

0.407

High

1440679

LAR4
La-related protein Larp4B

1

3

High-throughput

0.407

High

1471831

Q9VMV9
Reticulon-like protein

1

1

High-throughput

0.407

High

1471832

Q9VNF8
Protein transport protein SEC23

1

7

High-throughput

0.407

High

1471830

Q9VL29
GEO11246p1

2

0

High-throughput

0.298

High

1471845

LSM12
LSM12 homolog A

1

0

High-throughput

0.249

Low

1471852

Q9W3Z4
GH18625p

1

0

High-throughput

0.249

Low

1471854

TAFAB
Transcription initiation factor TFIID subunit 10b

1

0

High-throughput

0.249

Low

1031652

UMPS
Uridine 5'-monophosphate synthase

1

0

High-throughput

0.232

Low

1069267

Q0E8G6
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.232

Low

1069928

Q0E996
Eukaryotic translation initiation factor 4 gamma 2

1

0

High-throughput

0.232

Low

1346419

MESD
LDLR chaperone boca

1

0

High-throughput

0.232

Low

1471843

Q9VXZ3
Ben, isoform C

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025