Protein: MED6
Mediator of RNA polymerase II transcription subunit 6 (Mediator complex subunit 6) (dMED6)

Gene: MED6
Organism: Drosophila melanogaster
Interactions: 81
UniProt ID: Q8MSX2

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0006357 - regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1321553

MED22
Mediator of RNA polymerase II transcription subunit 22

2

3

Small-scale

0.776

High

58476

MED8
Mediator of RNA polymerase II transcription subunit 8

2

1

High-throughput

0.737

High

1321550

MED10
Mediator of RNA polymerase II transcription subunit 10

2

4

High-throughput

0.737

High

1321576

CDK8
Cyclin-dependent kinase 8

2

4

High-throughput

0.737

High

1019276

MED20
Mediator of RNA polymerase II transcription subunit 20

3

1

Small-scale

0.664

High

1321559

MED17
Mediator of RNA polymerase II transcription subunit 17

3

1

Small-scale

0.664

High

1321579

MED11
Mediator of RNA polymerase II transcription subunit 11

3

1

Small-scale

0.650

High

1321589

MED30
Mediator of RNA polymerase II transcription subunit 30

3

1

Small-scale

0.650

High

1321573

MED4
Mediator of RNA polymerase II transcription subunit 4

3

1

Small-scale

0.624

High

674029

BRM
ATP-dependent helicase brm

2

1

High-throughput

0.571

High

1267048

MED29
Mediator of RNA polymerase II transcription subunit 29

2

2

High-throughput

0.571

High

1302875

MED31
Mediator of RNA polymerase II transcription subunit 31

2

3

High-throughput

0.571

High

1321546

EBI
F-box-like/WD repeat-containing protein ebi

2

2

High-throughput

0.571

High

1321551

MED7
Mediator of RNA polymerase II transcription subunit 7

2

4

High-throughput

0.571

High

1321560

Q9VF03
Brahma associated protein 155 kDa

2

2

High-throughput

0.571

High

1321570

MED27
Mediator of RNA polymerase II transcription subunit 27

2

1

High-throughput

0.571

High

1321575

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

2

2

High-throughput

0.571

High

1321585

BAP60
Brahma-associated protein of 60 kDa

2

1

High-throughput

0.571

High

1321590

MED14
Mediator of RNA polymerase II transcription subunit 14

2

3

High-throughput

0.571

High

1321591

MED23
Mediator of RNA polymerase II transcription subunit 23

2

1

High-throughput

0.571

High

1321592

MED16
Mediator of RNA polymerase II transcription subunit 16

2

1

High-throughput

0.571

High

1321595

MED18
Mediator of RNA polymerase II transcription subunit 18

2

2

High-throughput

0.571

High

1321596

MED15
Mediator of RNA polymerase II transcription subunit 15

2

1

High-throughput

0.571

High

900641

DSH
Segment polarity protein dishevelled

2

0

High-throughput

0.547

High

1261393

Q7JQT8
LD41464p

2

0

High-throughput

0.547

High

1321492

ENC
Protein encore

2

0

High-throughput

0.547

High

1321544

MESD
LDLR chaperone boca

2

0

High-throughput

0.547

High

1321558

Q9VEB9
Sequence-specific single-stranded DNA-binding protein, isoform A

2

0

High-throughput

0.547

High

1321567

Q9VL29
GEO11246p1

2

0

High-throughput

0.547

High

1321556

MED28
Mediator of RNA polymerase II transcription subunit 28

1

1

Small-scale

0.536

High

56984

A1ZAK9
P-element somatic inhibitor, isoform A

1

2

High-throughput

0.479

High

788286

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

2

Small-scale

0.479

High

1321554

MED26
Mediator of RNA polymerase II transcription subunit 26

1

1

Small-scale

0.479

High

1321572

Q9VR42
Serine/threonine-protein kinase RIO3

1

1

High-throughput

0.479

High

1019340

MAX
Protein max

1

2

High-throughput

0.457

High

1302264

Q8I942
IP11514p

1

1

High-throughput

0.451

High

56938

A1ZAK7
LD35640p

1

2

High-throughput

0.445

High

1269600

MED13
Mediator of RNA polymerase II transcription subunit 13

1

3

High-throughput

0.445

High

1321542

Q8SXP8
TAR DNA-binding protein 43

1

1

High-throughput

0.445

High

1321557

MED25
Mediator of RNA polymerase II transcription subunit 25

1

2

High-throughput

0.445

High

1321574

MED24
Mediator of RNA polymerase II transcription subunit 24

1

1

High-throughput

0.445

High

1321580

MED12
Mediator of RNA polymerase II transcription subunit 12

1

2

High-throughput

0.445

High

1321593

Q9W3G1
Uncharacterized protein, isoform A

1

1

High-throughput

0.445

High

118133

M9MSK1
Uncharacterized protein, isoform B

1

1

High-throughput

0.439

High

1019219

P91632
Mushroom-body expressed, isoform A

1

0

High-throughput

0.438

High

1070388

Q0IGU7
HLH54F

1

0

High-throughput

0.438

High

1321561

Q9VF15
GEO09476p1

1

0

High-throughput

0.438

High

1321565

Q9VKC5
RH17958p

1

0

High-throughput

0.438

High

1321568

EI3F1
Eukaryotic translation initiation factor 3 subunit F-1

1

0

High-throughput

0.438

High

1321571

Q9VQ77
LD29420p

1

0

High-throughput

0.438

High

1321581

ANX11
Annexin B11

1

0

High-throughput

0.438

High

1321584

Q9VYA4
Ribonuclease H2 subunit B

1

0

High-throughput

0.438

High

197458

O18353
CHIP

1

0

High-throughput

0.426

High

1171869

Q24090
GH08712p

1

0

High-throughput

0.426

High

1263885

Q7K012
Brahma associated protein 55kD

1

0

High-throughput

0.426

High

1303602

OSA
Trithorax group protein osa

1

0

High-throughput

0.426

High

1321548

Q960F7
SD03629p

1

0

High-throughput

0.426

High

1321549

Q9BIW6
Brahma-associated protein 111kD

1

0

High-throughput

0.426

High

1321586

Q9VYK0
Smrter, isoform D

1

0

High-throughput

0.426

High

53572

A1Z813
Secretory 24AB, isoform A

1

1

High-throughput

0.407

High

1321569

Q9VNF8
Protein transport protein SEC23

1

1

High-throughput

0.407

High

1321582

Q9VXX0
GH05991p

2

0

High-throughput

0.310

High

1321594

GRCR2
Glutaredoxin domain-containing cysteine-rich protein CG12206

2

0

High-throughput

0.310

High

1321552

LAR4
La-related protein Larp4B

2

0

High-throughput

0.298

High

1321578

Q9VUB7
PAX-interacting protein 1

2

0

High-throughput

0.298

High

1321588

Q9W0L7
ubiquitinyl hydrolase 1

2

0

High-throughput

0.298

High

1321566

ZUC
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.249

Low

1321587

Q9VYZ8
GEO08286p1

1

0

High-throughput

0.249

Low

652053

ATC1
Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type

1

0

High-throughput

0.238

Low

1216771

Q5U124
alpha-glucosidase

1

0

High-throughput

0.238

Low

1264977

Q7K1T1
LD44824p

1

0

High-throughput

0.238

Low

1321545

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.238

Low

1321555

Q9VB99
LD03691p

1

0

High-throughput

0.238

Low

1321562

Q9VI64
LD30995p

1

0

High-throughput

0.238

Low

1321563

Q9VIE8
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.238

Low

1321564

Q9VJD4
LD24721p

1

0

High-throughput

0.238

Low

1321577

NPLP2
Neuropeptide-like 2

1

0

High-throughput

0.238

Low

1321583

Q9VY14
Uncharacterized protein

1

0

High-throughput

0.238

Low

84714

UNR
RNA-binding protein Unr

1

0

High-throughput

0.232

Low

1321543

Q8T4A8
AT07769p

1

0

High-throughput

0.232

Low

1321547

Q95TT5
LD24616p

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025