Protein: MED4
Mediator of RNA polymerase II transcription subunit 4 (Mediator complex subunit 4) (dp34)

Gene: MED4
Organism: Drosophila melanogaster
Interactions: 96
UniProt ID: Q9VS38

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0016592 - mediator complex
GO:0045893 - positive regulation of DNA-templated transcription

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

57411

MED9
Mediator of RNA polymerase II transcription subunit 9

3

1

High-throughput

0.843

High

1485355

MED21
Mediator of RNA polymerase II transcription subunit 21

2

1

High-throughput

0.767

High

1428105

MED7
Mediator of RNA polymerase II transcription subunit 7

2

1

High-throughput

0.737

High

1485350

MED14
Mediator of RNA polymerase II transcription subunit 14

2

1

High-throughput

0.737

High

1427996

MED10
Mediator of RNA polymerase II transcription subunit 10

3

1

Small-scale

0.629

High

1321573

MED6
Mediator of RNA polymerase II transcription subunit 6

3

1

Small-scale

0.624

High

916506

RFC2
Replication factor C subunit 2

2

0

High-throughput

0.598

High

1302893

MED31
Mediator of RNA polymerase II transcription subunit 31

1

2

High-throughput

0.575

High

1483008

MED1
Mediator of RNA polymerase II transcription subunit 1

1

1

High-throughput

0.575

High

58507

MED8
Mediator of RNA polymerase II transcription subunit 8

2

1

High-throughput

0.571

High

900669

DSH
Segment polarity protein dishevelled

2

1

High-throughput

0.571

High

1019298

MED20
Mediator of RNA polymerase II transcription subunit 20

2

1

High-throughput

0.571

High

1267067

MED29
Mediator of RNA polymerase II transcription subunit 29

2

1

High-throughput

0.571

High

1269629

MED13
Mediator of RNA polymerase II transcription subunit 13

2

2

High-throughput

0.571

High

1377795

EBI
F-box-like/WD repeat-containing protein ebi

2

1

High-throughput

0.571

High

1472609

MED17
Mediator of RNA polymerase II transcription subunit 17

2

1

High-throughput

0.571

High

1473440

Q9VF03
Brahma associated protein 155 kDa

2

3

High-throughput

0.571

High

1482734

MED27
Mediator of RNA polymerase II transcription subunit 27

2

2

High-throughput

0.571

High

1485336

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

2

2

High-throughput

0.571

High

1485337

CDK8
Cyclin-dependent kinase 8

2

3

High-throughput

0.571

High

1485342

MED11
Mediator of RNA polymerase II transcription subunit 11

2

1

High-throughput

0.571

High

1485346

BAP60
Brahma-associated protein of 60 kDa

2

2

High-throughput

0.571

High

1485349

MED30
Mediator of RNA polymerase II transcription subunit 30

2

1

High-throughput

0.571

High

1485351

MED23
Mediator of RNA polymerase II transcription subunit 23

2

1

High-throughput

0.571

High

1485352

MED16
Mediator of RNA polymerase II transcription subunit 16

2

1

High-throughput

0.571

High

1485357

MED18
Mediator of RNA polymerase II transcription subunit 18

2

1

High-throughput

0.571

High

1468542

LARP
La-related protein 1

2

2

High-throughput

0.570

High

1261425

Q7JQT8
LD41464p

2

0

High-throughput

0.547

High

1472583

Q9VEB9
Sequence-specific single-stranded DNA-binding protein, isoform A

2

0

High-throughput

0.547

High

1480265

Q9VL29
GEO11246p1

2

0

High-throughput

0.547

High

1261942

Q7JUF2
Diego, isoform A

2

2

High-throughput

0.542

High

1346436

MESD
LDLR chaperone boca

2

1

High-throughput

0.521

High

1440697

LAR4
La-related protein Larp4B

2

2

High-throughput

0.521

High

1485339

Q9VUB7
PAX-interacting protein 1

2

1

High-throughput

0.521

High

479031

ZEN1
Protein zerknuellt 1

1

0

High-throughput

0.486

High

1070398

Q0IGU7
HLH54F

1

0

High-throughput

0.486

High

1378888

TF2H1
General transcription factor IIH subunit 1

1

0

High-throughput

0.486

High

1472730

Q9VEF5
Inhibitor of growth protein

1

0

High-throughput

0.486

High

1485344

Q9VW52
Precursor RNA processing 3, isoform A

1

0

High-throughput

0.486

High

1465849

MED26
Mediator of RNA polymerase II transcription subunit 26

1

1

Small-scale

0.479

High

1484616

Q9VR42
Serine/threonine-protein kinase RIO3

1

1

High-throughput

0.479

High

1485359

MED15
Mediator of RNA polymerase II transcription subunit 15

1

2

High-throughput

0.479

High

930484

CNN
Centrosomin

1

1

High-throughput

0.464

High

1464222

A36DE
Accessory gland protein Acp36DE

1

2

High-throughput

0.464

High

1485353

Q9W3A1
Uncharacterized protein, isoform A

1

2

High-throughput

0.464

High

1485356

Q9XZ12
Protein FAM91A1

1

1

High-throughput

0.464

High

674054

BRM
ATP-dependent helicase brm

1

0

High-throughput

0.458

High

54858

A1Z904
Dystrobrevin

1

3

High-throughput

0.451

High

1304316

Q8INY5
RE08003p1

1

1

High-throughput

0.451

High

1478253

Q9VJ95
Protein tyrosine phosphatase 36E, isoform A

1

1

High-throughput

0.451

High

1484409

Q9VQS1
FI08260p

1

3

High-throughput

0.451

High

1409395

Q9BIW6
Brahma-associated protein 111kD

1

1

High-throughput

0.445

High

1465339

MED22
Mediator of RNA polymerase II transcription subunit 22

1

1

High-throughput

0.445

High

1471835

MED25
Mediator of RNA polymerase II transcription subunit 25

1

1

High-throughput

0.445

High

1485335

MED24
Mediator of RNA polymerase II transcription subunit 24

1

1

High-throughput

0.445

High

1485341

MED19
Mediator of RNA polymerase II transcription subunit 19

1

1

High-throughput

0.445

High

1485343

MED12
Mediator of RNA polymerase II transcription subunit 12

1

3

High-throughput

0.445

High

120160

M9PCH6
Venom dipeptidyl peptidase 4

1

1

High-throughput

0.439

High

120906

M9PEF7
Puratrophin-1-like, isoform D

1

1

High-throughput

0.439

High

1069999

Q0E9B2
Dystrobrevin

1

3

High-throughput

0.439

High

1320952

Q8MQJ7
Autophagy-related 1, isoform B

1

1

High-throughput

0.439

High

1485360

R9PY49
Uncharacterized protein, isoform C

1

3

High-throughput

0.439

High

1485361

X2JEH3
Uncharacterized protein, isoform E

1

1

High-throughput

0.439

High

197481

O18353
CHIP

1

0

High-throughput

0.426

High

1171914

Q24090
GH08712p

1

0

High-throughput

0.426

High

1303626

OSA
Trithorax group protein osa

1

0

High-throughput

0.426

High

1485354

Q9W3G1
Uncharacterized protein, isoform A

1

0

High-throughput

0.426

High

1269711

Q7KU88
Puratrophin-1-like, isoform B

1

2

High-throughput

0.417

High

1485338

Q9VU14
Autophagy-related 1, isoform A

1

1

High-throughput

0.417

High

1485340

Q9VUH1
Venom dipeptidyl peptidase 4

1

1

High-throughput

0.417

High

1476839

Q9VHV6
RE31520p

2

0

High-throughput

0.325

High

1378937

Q960F7
SD03629p

2

0

High-throughput

0.298

High

1484391

EXOC2
Exocyst complex component 2

1

0

High-throughput

0.282

High

52221

A1Z6Q0
Klaroid, isoform D

1

0

High-throughput

0.265

Low

732239

RL7
Large ribosomal subunit protein uL30

1

0

High-throughput

0.265

Low

1344382

Q8SYC3
RE68569p

1

0

High-throughput

0.265

Low

1345922

GAP2
Ras GTPase-activating protein raskol

1

0

High-throughput

0.265

Low

1428025

NUP88
Nuclear pore complex protein Nup88

1

0

High-throughput

0.265

Low

1464302

Q9V3U7
GEO12036p1

1

0

High-throughput

0.265

Low

1471445

S35B1
Solute carrier family 35 member B1 homolog

1

0

High-throughput

0.265

Low

1471820

NAA25
Phagocyte signaling-impaired protein

1

0

High-throughput

0.265

Low

1471978

Q9VDW9
LP03867p

1

0

High-throughput

0.265

Low

1476300

Q9VHL2
T-complex protein 1 subunit eta

1

0

High-throughput

0.265

Low

1484567

Q9VR24
Uncharacterized protein, isoform A

1

0

High-throughput

0.265

Low

1485345

Q9VX05
Uncharacterized protein

1

0

High-throughput

0.265

Low

1485347

Q9W0K9
LD10220p

1

0

High-throughput

0.265

Low

1485358

DNK
Deoxynucleoside kinase

1

0

High-throughput

0.265

Low

1479626

Q9VKI8
GH03305p

1

0

High-throughput

0.251

Low

1266278

Q7K485
Cathepsin D

1

0

High-throughput

0.249

Low

1377487

Q95RF6
LD34461p

1

0

High-throughput

0.249

Low

53596

A1Z813
Secretory 24AB, isoform A

1

0

High-throughput

0.232

Low

84726

UNR
RNA-binding protein Unr

1

0

High-throughput

0.232

Low

1069935

Q0E996
Eukaryotic translation initiation factor 4 gamma 2

1

0

High-throughput

0.232

Low

1174849

NETA
Netrin-A

1

0

High-throughput

0.232

Low

1321518

ENC
Protein encore

1

0

High-throughput

0.232

Low

1485348

Q9W0L7
ubiquitinyl hydrolase 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025