Protein: SYSM
Serine--tRNA ligase, mitochondrial (EC 6.1.1.11) (SerRSmt) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)

Gene: SYSM, SARS2
Organism: Homo sapiens
Interactions: 87
UniProt ID: Q9NP81

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0003723 - RNA binding
GO:0004828 - serine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1446013

KCMF1
E3 ubiquitin-protein ligase KCMF1

5

0

Small-scale

0.682

High

1446020

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

3

2

Small-scale

0.650

High

1114369

CUL3
Cullin-3

2

9

High-throughput

0.611

High

1310436

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

4

High-throughput

0.611

High

1388931

FBX17
F-box only protein 17

2

1

High-throughput

0.611

High

1212859

UBR4
E3 ubiquitin-protein ligase UBR4

2

1

High-throughput

0.601

High

243010

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

1392922

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

1227505

A16L1
Autophagy-related protein 16-1

2

5

High-throughput

0.571

High

275391

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

2

High-throughput

0.536

High

349710

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

1

1

High-throughput

0.536

High

1123440

ICT1
Large ribosomal subunit protein mL62

1

2

High-throughput

0.536

High

1161687

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.536

High

1325694

GUF1
Translation factor GUF1, mitochondrial

1

3

High-throughput

0.536

High

1446015

NPS3A
Protein NipSnap homolog 3A

1

3

High-throughput

0.536

High

897554

BPL1
Biotin--protein ligase

1

0

High-throughput

0.518

High

1446018

PUF60
Poly(U)-binding-splicing factor PUF60

1

2

High-throughput

0.515

High

61648

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.513

High

1397661

IMP1L
Mitochondrial inner membrane protease subunit 1

1

0

High-throughput

0.513

High

186042

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

9

High-throughput

0.501

High

397002

ESR1
Estrogen receptor

1

3

Small-scale

0.501

High

508676

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.501

High

465660

IGF1R
Insulin-like growth factor 1 receptor

1

7

High-throughput

0.500

High

1066251

DMWD
Dystrophia myotonica WD repeat-containing protein

1

5

High-throughput

0.489

High

1429925

UBP44
Ubiquitin carboxyl-terminal hydrolase 44

1

3

High-throughput

0.489

High

316039

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

320069

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

340942

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

4

High-throughput

0.479

High

401531

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

412652

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.479

High

468828

HS90B
Heat shock protein HSP 90-beta

1

13

High-throughput

0.479

High

471264

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

4

High-throughput

0.479

High

505459

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

1

High-throughput

0.479

High

532989

CH60
60 kDa heat shock protein, mitochondrial

1

5

High-throughput

0.479

High

560107

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

1

High-throughput

0.479

High

767346

MERL
Merlin

1

2

High-throughput

0.479

High

831476

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

856394

IF2M
Translation initiation factor IF-2, mitochondrial

1

5

High-throughput

0.479

High

884400

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

1

Small-scale

0.479

High

971121

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.479

High

990992

UBE2B
Ubiquitin-conjugating enzyme E2 B

1

1

Small-scale

0.479

High

1112724

CUL1
Cullin-1

1

9

Small-scale

0.479

High

1117853

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

4

High-throughput

0.479

High

1140899

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

1142676

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.479

High

1162571

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

1

High-throughput

0.479

High

1178394

CL16A
Protein CLEC16A

1

2

High-throughput

0.479

High

1235534

IFIX
Pyrin and HIN domain-containing protein 1

1

1

High-throughput

0.479

High

1383564

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

1389907

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

3

High-throughput

0.479

High

1397453

CI072
Guanine nucleotide exchange factor C9orf72

1

3

High-throughput

0.479

High

1435326

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1436097

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

4

High-throughput

0.479

High

1446011

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

4

High-throughput

0.479

High

1446016

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

1446017

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

238617

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.458

High

852043

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

983983

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.458

High

992344

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.458

High

1234537

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

1271152

TM10C
tRNA methyltransferase 10 homolog C

1

0

Small-scale

0.458

High

1341193

PPTC7
Protein phosphatase PTC7 homolog

1

0

High-throughput

0.458

High

1347809

SPT20
Spermatogenesis-associated protein 20

1

0

High-throughput

0.458

High

1415681

TR61B
tRNA

1

0

High-throughput

0.458

High

1446012

AATF
Protein AATF

1

0

High-throughput

0.458

High

1446022

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.458

High

414672

P53
Cellular tumor antigen p53

1

3

Small-scale

0.445

High

430388

JUN
Transcription factor Jun

1

9

High-throughput

0.445

High

1108181

SQSTM
Sequestosome-1

1

2

High-throughput

0.445

High

1446021

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

3

High-throughput

0.445

High

279508

TULP3
Tubby-related protein 3

1

1

High-throughput

0.437

High

589762

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

769249

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

1156866

E2F4
Transcription factor E2F4

1

1

High-throughput

0.437

High

1255651

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.437

High

1327212

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.437

High

1393720

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.437

High

1433962

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.437

High

1121532

KEAP1
Kelch-like ECH-associated protein 1

1

0

High-throughput

0.426

High

1212543

CAF17
Iron-sulfur cluster assembly factor IBA57, mitochondrial

1

0

High-throughput

0.426

High

1311178

UBR2
E3 ubiquitin-protein ligase UBR2

1

0

High-throughput

0.426

High

1446019

NFU1
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial

1

0

High-throughput

0.426

High

1030218

IL5RA
Interleukin-5 receptor subunit alpha

1

1

High-throughput

0.407

High

1446014

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

2

0

High-throughput

0.313

High

937926

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.249

Low

378443

IFNG
Interferon gamma

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025