Protein: GUF1
Translation factor GUF1, mitochondrial (EC 3.6.5.-) (Elongation factor 4 homolog) (EF-4) (GTPase GUF1) (Ribosomal back-translocase)

Gene: GUF1
Organism: Homo sapiens
Interactions: 105
UniProt ID: Q8N442

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1325707

RT07
Small ribosomal subunit protein uS7m

2

4

High-throughput

0.628

High

183682

RT12
Small ribosomal subunit protein uS12m

1

2

High-throughput

0.618

High

851949

EFTS
Elongation factor Ts, mitochondrial

1

7

High-throughput

0.618

High

856310

IF2M
Translation initiation factor IF-2, mitochondrial

1

12

High-throughput

0.618

High

882777

EFTU
Elongation factor Tu, mitochondrial

1

6

High-throughput

0.618

High

1325676

RRFM
Ribosome-recycling factor, mitochondrial

1

1

High-throughput

0.618

High

1325679

EFGM
Elongation factor G, mitochondrial

1

15

High-throughput

0.618

High

1325690

MTG2
Mitochondrial ribosome-associated GTPase 2

1

4

High-throughput

0.618

High

1325709

RM11
Large ribosomal subunit protein uL11m

1

2

High-throughput

0.618

High

378135

TNFA
Tumor necrosis factor

3

3

High-throughput

0.609

High

279829

CISY
Citrate synthase, mitochondrial

2

2

High-throughput

0.584

High

1162421

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

4

High-throughput

0.584

High

562221

LAMP2
Lysosome-associated membrane glycoprotein 2

2

1

High-throughput

0.574

High

1128921

I13R2
Interleukin-13 receptor subunit alpha-2

2

1

High-throughput

0.574

High

1325668

TSYL6
Testis-specific Y-encoded-like protein 6

2

1

High-throughput

0.574

High

1325701

C5AR2
C5a anaphylatoxin chemotactic receptor 2

2

5

High-throughput

0.574

High

271072

PTCD1
Pentatricopeptide repeat-containing protein 1, mitochondrial

1

2

High-throughput

0.536

High

869191

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

1

High-throughput

0.536

High

1242595

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

1

High-throughput

0.536

High

1310223

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.536

High

1325678

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

1

High-throughput

0.536

High

1325694

SYSM
Serine--tRNA ligase, mitochondrial

1

3

High-throughput

0.536

High

1325708

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

396499

ESR1
Estrogen receptor

2

8

High-throughput

0.521

High

1325670

HUMMR
Protein MGARP

1

0

High-throughput

0.513

High

1325704

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

249168

DSCAM
Cell adhesion molecule DSCAM

1

4

High-throughput

0.494

High

133279

P2Y10
Putative P2Y purinoceptor 10

1

4

High-throughput

0.489

High

220180

TNF14
Tumor necrosis factor ligand superfamily member 14

1

3

High-throughput

0.489

High

473503

FCG3A
Low affinity immunoglobulin gamma Fc region receptor III-A

1

2

High-throughput

0.489

High

731880

CEAM8
Cell adhesion molecule CEACAM8

1

2

High-throughput

0.489

High

848677

MAGA9
Melanoma-associated antigen 9

1

2

High-throughput

0.489

High

867988

GLR
Glucagon receptor

1

1

High-throughput

0.489

High

880174

PTH2R
Parathyroid hormone 2 receptor

1

1

High-throughput

0.489

High

1177165

MICB
MHC class I polypeptide-related sequence B

1

2

High-throughput

0.489

High

1198418

LRC23
Leucine-rich repeat-containing protein 23

1

1

High-throughput

0.489

High

1316211

S22AF
Solute carrier family 22 member 15

1

1

High-throughput

0.489

High

1325681

PFD5
Prefoldin subunit 5

1

1

High-throughput

0.489

High

1325710

GPR45
Probable G-protein coupled receptor 45

1

3

High-throughput

0.489

High

61552

VWA8
von Willebrand factor A domain-containing protein 8

1

2

High-throughput

0.479

High

66237

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

1

High-throughput

0.479

High

287330

RF1M
Peptide chain release factor 1, mitochondrial

1

5

High-throughput

0.479

High

350923

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

2

High-throughput

0.479

High

471129

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

5

High-throughput

0.479

High

487527

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

519162

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.479

High

786165

LONM
Lon protease homolog, mitochondrial

1

5

High-throughput

0.479

High

828850

MDHM
Malate dehydrogenase, mitochondrial

1

3

High-throughput

0.479

High

841827

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

2

High-throughput

0.479

High

1024100

TFAM
Transcription factor A, mitochondrial

1

4

High-throughput

0.479

High

1048594

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

4

High-throughput

0.479

High

1058137

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

High-throughput

0.479

High

1083668

MPPA
Mitochondrial-processing peptidase subunit alpha

1

6

High-throughput

0.479

High

1087454

GRSF1
G-rich sequence factor 1

1

8

High-throughput

0.479

High

1090463

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

13

High-throughput

0.479

High

1117779

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

7

High-throughput

0.479

High

1123348

ICT1
Large ribosomal subunit protein mL62

1

2

High-throughput

0.479

High

1142598

PDK1
[Pyruvate dehydrogenase

1

3

High-throughput

0.479

High

1207072

SYAM
Alanine--tRNA ligase, mitochondrial

1

4

High-throughput

0.479

High

1234449

MRM1
rRNA methyltransferase 1, mitochondrial

1

3

High-throughput

0.479

High

1240304

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

2

High-throughput

0.479

High

1271453

DHX30
ATP-dependent RNA helicase DHX30

1

2

High-throughput

0.479

High

1325671

FAKD4
FAST kinase domain-containing protein 4

1

8

High-throughput

0.479

High

1325672

MCUR1
Mitochondrial calcium uniporter regulator 1

1

2

High-throughput

0.479

High

1325674

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

2

High-throughput

0.479

High

1325677

MTEF3
Transcription termination factor 3, mitochondrial

1

2

High-throughput

0.479

High

1325680

IMP2L
Mitochondrial inner membrane protease subunit 2

1

2

High-throughput

0.479

High

1325682

TACO1
Translational activator of cytochrome c oxidase 1

1

3

High-throughput

0.479

High

1325683

TR61B
tRNA

1

2

High-throughput

0.479

High

1325684

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

5

High-throughput

0.479

High

1325685

RT26
Small ribosomal subunit protein mS26

1

2

High-throughput

0.479

High

1325687

IF3M
Translation initiation factor IF-3, mitochondrial

1

2

High-throughput

0.479

High

1325688

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

2

High-throughput

0.479

High

1325689

MTRFR
Mitochondrial translation release factor in rescue

1

5

High-throughput

0.479

High

1325692

MET17
Ribosome assembly protein METTL17, mitochondrial

1

2

High-throughput

0.479

High

1325693

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

4

High-throughput

0.479

High

1325695

NGRN
Neugrin

1

1

High-throughput

0.479

High

1325696

DDX28
Probable ATP-dependent RNA helicase DDX28

1

4

High-throughput

0.479

High

1325697

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

4

High-throughput

0.479

High

1325699

MRES1
Mitochondrial transcription rescue factor 1

1

1

High-throughput

0.479

High

1325702

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

5

High-throughput

0.479

High

1270580

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

1325673

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

1325675

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

0

High-throughput

0.458

High

1325698

ATD3A
ATPase family AAA domain-containing protein 3A

1

12

High-throughput

0.445

High

138215

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

7

High-throughput

0.437

High

353444

AGR2
Anterior gradient protein 2 homolog

1

2

High-throughput

0.437

High

372567

MYC
Myc proto-oncogene protein

1

8

High-throughput

0.437

High

879268

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.437

High

1254626

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.437

High

1325691

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.437

High

1325703

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.437

High

1325705

XPO7
Exportin-7

1

4

High-throughput

0.437

High

1271244

SV2B
Synaptic vesicle glycoprotein 2B

1

2

High-throughput

0.407

High

1325686

TKTL2
Transketolase-like protein 2

1

5

High-throughput

0.407

High

1325706

ITM2B
Integral membrane protein 2B

1

5

High-throughput

0.407

High

1248483

TMCO3
Transmembrane and coiled-coil domain-containing protein 3

2

0

High-throughput

0.328

High

1325669

F174A
Membrane protein FAM174A

2

0

High-throughput

0.328

High

260778

RAMP2
Receptor activity-modifying protein 2

1

0

High-throughput

0.279

Low

847784

SSRB
Translocon-associated protein subunit beta

1

0

High-throughput

0.279

Low

1292391

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

0

High-throughput

0.279

Low

1324821

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.279

Low

1325700

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.279

Low

1106609

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.249

Low

222303

PSCA
Prostate stem cell antigen

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025