Protein: ICAL
Calpastatin (Calpain inhibitor) (Sperm BS-17 component)

Gene: ICAL, CAST
Organism: Homo sapiens
Interactions: 66
UniProt ID: P20810

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0004866 - endopeptidase inhibitor activity
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

457042

CAN1
Calpain-1 catalytic subunit

6

5

Small-scale

0.943

High

635139

CPNS2
Calpain small subunit 2

4

6

High-throughput

0.892

High

65513

CAN8
Calpain-8

2

6

High-throughput

0.811

High

605965

CAN2
Calpain-2 catalytic subunit

2

5

Small-scale

0.789

High

635117

FNTB
Protein farnesyltransferase subunit beta

3

0

High-throughput

0.638

High

635130

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

8

High-throughput

0.628

High

602731

AATC
Aspartate aminotransferase, cytoplasmic

1

1

High-throughput

0.536

High

635115

BAG6
Large proline-rich protein BAG6

1

6

High-throughput

0.536

High

300918

RL1D1
Ribosomal L1 domain-containing protein 1

1

3

High-throughput

0.515

High

426444

HMGN2
Non-histone chromosomal protein HMG-17

1

1

High-throughput

0.515

High

387786

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

0

High-throughput

0.513

High

563183

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

635120

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

635121

SUMO2
Small ubiquitin-related modifier 2

1

2

High-throughput

0.501

High

276753

TBCA
Tubulin-specific chaperone A

1

1

High-throughput

0.479

High

345364

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

5

High-throughput

0.479

High

362157

ABL1
Tyrosine-protein kinase ABL1

1

5

High-throughput

0.479

High

400270

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

440358

FYN
Tyrosine-protein kinase Fyn

1

5

High-throughput

0.479

High

555866

CADH1
Cadherin-1

1

2

High-throughput

0.479

High

557084

SRC
Proto-oncogene tyrosine-protein kinase Src

1

5

High-throughput

0.479

High

582661

EZRI
Ezrin

1

4

High-throughput

0.479

High

593903

NCK1
SH2/SH3 adapter protein NCK1

1

9

High-throughput

0.479

High

606213

CEBPB
CCAAT/enhancer-binding protein beta

1

6

High-throughput

0.479

High

618970

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

2

High-throughput

0.479

High

620127

NUCL
Nucleolin

1

3

High-throughput

0.479

High

635111

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

1

High-throughput

0.479

High

635114

CRK
Adapter molecule crk

1

10

High-throughput

0.479

High

635116

YAP1
Transcriptional coactivator YAP1

1

8

High-throughput

0.479

High

635118

GSK3B
Glycogen synthase kinase-3 beta

1

5

High-throughput

0.479

High

635119

F10A1
Hsc70-interacting protein

1

4

High-throughput

0.479

High

635122

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

635123

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

4

High-throughput

0.479

High

635124

GRB2
Growth factor receptor-bound protein 2

1

11

High-throughput

0.479

High

635125

H31
Histone H3.1

1

12

High-throughput

0.479

High

635129

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

635133

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

635134

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

635135

SMC5
Structural maintenance of chromosomes protein 5

1

8

High-throughput

0.479

High

635136

ARFG2
ADP-ribosylation factor GTPase-activating protein 2

1

3

High-throughput

0.479

High

635137

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

635138

UBXN4
UBX domain-containing protein 4

1

1

High-throughput

0.479

High

635143

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

635146

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

635147

TBK1
Serine/threonine-protein kinase TBK1

1

3

High-throughput

0.479

High

635148

FZR1
Fizzy-related protein homolog

1

8

High-throughput

0.479

High

210527

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

0

High-throughput

0.458

High

257224

PQBP1
Polyglutamine-binding protein 1

1

0

High-throughput

0.458

High

635113

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

635132

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

635140

MBB1A
Myb-binding protein 1A

1

0

High-throughput

0.458

High

635141

REN3B
Regulator of nonsense transcripts 3B

1

0

High-throughput

0.458

High

635145

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

635149

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.458

High

635142

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

635144

PDLI7
PDZ and LIM domain protein 7

1

5

High-throughput

0.445

High

105318

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

502236

H2A1
Histone H2A type 1

1

5

High-throughput

0.437

High

635110

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

635112

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

635126

RON
Macrophage-stimulating protein receptor

1

4

High-throughput

0.437

High

62447

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.426

High

404662

PRIO
Major prion protein

1

0

High-throughput

0.426

High

635127

DPOE1
DNA polymerase epsilon catalytic subunit A

1

0

High-throughput

0.249

Low

635128

PAF15
PCNA-associated factor

1

0

Small-scale

0.249

Low

635131

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025