Protein: PQBP1
Polyglutamine-binding protein 1 (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38) (Polyglutamine tract-binding protein 1)

Gene: PQBP1
Organism: Homo sapiens
Interactions: 90
UniProt ID: O60828

Gene Ontology (top 5):
GO:0000380 - alternative mRNA splicing, via spliceosome
GO:0002218 - activation of innate immune response
GO:0002230 - positive regulation of defense response to virus by host
GO:0003677 - DNA binding
GO:0003690 - double-stranded DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

257285

WBP11
WW domain-binding protein 11

7

0

Small-scale

0.719

High

257251

MARE1
Microtubule-associated protein RP/EB family member 1

3

0

High-throughput

0.646

High

257253

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

2

1

High-throughput

0.628

High

257271

LZTS2
Leucine zipper putative tumor suppressor 2

2

0

High-throughput

0.618

High

257211

ESR1
Estrogen receptor

3

0

Small-scale

0.613

High

257240

TXN4A
Thioredoxin-like protein 4A

3

0

Small-scale

0.612

High

257228

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

2

2

High-throughput

0.611

High

257246

RBM39
RNA-binding protein 39

2

0

High-throughput

0.585

High

257231

ATX1
Ataxin-1

2

0

Small-scale

0.575

High

257207

BRD4
Bromodomain-containing protein 4

2

0

High-throughput

0.559

High

257225

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.537

High

257234

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

2

High-throughput

0.536

High

257235

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

2

High-throughput

0.536

High

257223

PO3F2
POU domain, class 3, transcription factor 2

1

0

Small-scale

0.529

High

224916

TLX3
T-cell leukemia homeobox protein 3

1

0

High-throughput

0.518

High

257238

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.518

High

257287

MED31
Mediator of RNA polymerase II transcription subunit 31

1

0

High-throughput

0.518

High

257216

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.513

High

257217

SNRPA
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.513

High

257218

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

257220

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

257222

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.513

High

257243

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.513

High

257244

ANK3
Ankyrin-3

1

0

High-throughput

0.513

High

257249

PP1R7
Protein phosphatase 1 regulatory subunit 7

1

0

High-throughput

0.513

High

257250

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.513

High

257269

RSRC1
Serine/Arginine-related protein 53

1

0

High-throughput

0.513

High

257275

GDF3
Growth/differentiation factor 3

1

0

High-throughput

0.513

High

257279

TFP11
Tuftelin-interacting protein 11

1

0

High-throughput

0.513

High

257280

SAE1
SUMO-activating enzyme subunit 1

1

0

High-throughput

0.513

High

257281

CSN7A
COP9 signalosome complex subunit 7a

1

0

High-throughput

0.513

High

257289

PAXB1
PAX3- and PAX7-binding protein 1

1

0

High-throughput

0.513

High

257270

MEP50
Methylosome protein WDR77

1

1

High-throughput

0.508

High

257230

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.505

High

257266

LNX1
E3 ubiquitin-protein ligase LNX

1

0

Small-scale

0.504

High

257229

HD
Huntingtin

1

0

High-throughput

0.493

High

245037

AQR
RNA helicase aquarius

1

0

High-throughput

0.486

High

257232

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

0

High-throughput

0.486

High

257264

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

1

High-throughput

0.481

High

126930

APBB1
Amyloid beta precursor protein binding family B member 1

1

0

High-throughput

0.480

High

257215

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

257210

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

257213

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

257258

BCOR
BCL-6 corepressor

1

1

High-throughput

0.479

High

257265

NUP43
Nucleoporin Nup43

1

1

High-throughput

0.479

High

257283

XPO7
Exportin-7

1

1

High-throughput

0.479

High

257286

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

1

High-throughput

0.479

High

257288

LSM4
U6 snRNA-associated Sm-like protein LSm4

1

1

High-throughput

0.479

High

257255

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.460

High

257276

RBM22
Pre-mRNA-splicing factor RBM22

1

0

High-throughput

0.460

High

134494

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.458

High

257206

PQBP1
Polyglutamine-binding protein 1

1

0

High-throughput

0.458

High

257208

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

257209

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

257212

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

257214

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

257224

ICAL
Calpastatin

1

0

High-throughput

0.458

High

257226

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.458

High

257236

H4
Histone H4

1

0

High-throughput

0.458

High

257237

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

257239

H31
Histone H3.1

1

0

High-throughput

0.458

High

257241

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

257247

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

257248

SF3A2
Splicing factor 3A subunit 2

1

0

High-throughput

0.458

High

257252

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

257257

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

257259

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

257260

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

257261

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

257262

STING
Stimulator of interferon genes protein

1

0

Small-scale

0.458

High

257263

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

257267

CELF1
CUGBP Elav-like family member 1

1

0

High-throughput

0.458

High

257268

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

0

High-throughput

0.458

High

257272

PCGF1
Polycomb group RING finger protein 1

1

0

High-throughput

0.458

High

257273

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

257277

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

257278

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

257282

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

257219

CLCB
Clathrin light chain B

1

0

High-throughput

0.438

High

257233

RAB8A
Ras-related protein Rab-8A

1

0

High-throughput

0.438

High

257256

RIF1
Telomere-associated protein RIF1

1

0

High-throughput

0.438

High

257245

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

257274

UBL5
Ubiquitin-like protein 5

1

0

Small-scale

0.426

High

257242

GOGA2
Golgin subfamily A member 2

2

0

High-throughput

0.337

High

257227

RECO
Recoverin

1

0

High-throughput

0.282

High

257284

ERG28
Ergosterol biosynthetic protein 28 homolog

1

0

High-throughput

0.282

High

257254

CE022
UPF0489 protein C5orf22

1

0

High-throughput

0.279

Low

257221

PSPC
Surfactant protein C

1

0

Small-scale

0.261

Low

62427

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025