Protein: CPNS2
Calpain small subunit 2 (CSS2) (Calcium-dependent protease small subunit 2)

Gene: CPNS2, CAPNS2
Organism: Homo sapiens
Interactions: 51
UniProt ID: Q96L46

Gene Ontology (top 5):
GO:0004198 - calcium-dependent cysteine-type endopeptidase activity
GO:0005509 - calcium ion binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0110158 - calpain complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

457123

CAN1
Calpain-1 catalytic subunit

4

14

High-throughput

0.892

High

635139

ICAL
Calpastatin

4

6

High-throughput

0.892

High

412973

CPNS1
Calpain small subunit 1

3

17

High-throughput

0.667

High

977798

ACTA
Actin, aortic smooth muscle

3

4

High-throughput

0.667

High

1308544

LIX1L
LIX1-like protein

4

1

High-throughput

0.630

High

1394249

GMCL1
Germ cell-less protein-like 1

3

5

High-throughput

0.609

High

1116686

RIN1
Ras and Rab interactor 1

2

2

High-throughput

0.606

High

1193365

GLYR1
Cytokine-like nuclear factor N-PAC

2

0

High-throughput

0.585

High

1156045

ZIC1
Zinc finger protein ZIC 1

2

3

High-throughput

0.574

High

1201034

ACTBL
Beta-actin-like protein 2

2

3

High-throughput

0.574

High

1396692

TB22B
TBC1 domain family member 22B

2

9

High-throughput

0.574

High

852679

PPIC
Peptidyl-prolyl cis-trans isomerase C

2

6

High-throughput

0.553

High

1324248

ARM10
Armadillo repeat-containing protein 10

2

1

High-throughput

0.553

High

1359884

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

2

1

High-throughput

0.553

High

132642

UPK1A
Uroplakin-1a

1

3

High-throughput

0.536

High

292721

RENR
Renin receptor

1

1

High-throughput

0.536

High

352725

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

1

High-throughput

0.536

High

391653

FRIH
Ferritin heavy chain

1

2

High-throughput

0.536

High

602827

AATC
Aspartate aminotransferase, cytoplasmic

1

2

High-throughput

0.536

High

733415

CCR1
C-C chemokine receptor type 1

1

3

High-throughput

0.536

High

1332796

FNDC5
Fibronectin type III domain-containing protein 5

1

2

High-throughput

0.536

High

1381466

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

3

High-throughput

0.536

High

1396690

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

20

High-throughput

0.536

High

1396693

KLH11
Kelch-like protein 11

1

6

High-throughput

0.536

High

884200

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

1292966

AROS
Active regulator of SIRT1

1

0

High-throughput

0.513

High

422900

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

282767

E2F6
Transcription factor E2F6

1

2

High-throughput

0.489

High

325347

OR2A4
Olfactory receptor 2A4

1

4

High-throughput

0.489

High

552354

ADT3
ADP/ATP translocase 3

1

3

High-throughput

0.489

High

876384

PTSS1
Phosphatidylserine synthase 1

1

3

High-throughput

0.489

High

1055631

GABPA
GA-binding protein alpha chain

1

1

High-throughput

0.489

High

1385189

SARAF
Store-operated calcium entry-associated regulatory factor

1

3

High-throughput

0.489

High

1396688

SH23A
SH2 domain-containing protein 3A

1

3

High-throughput

0.489

High

1396689

RBM42
RNA-binding protein 42

1

3

High-throughput

0.489

High

1396694

RFOX1
RNA binding protein fox-1 homolog 1

1

4

High-throughput

0.489

High

1396696

SSUH2
Protein SSUH2 homolog

1

2

High-throughput

0.489

High

299335

FLOT1
Flotillin-1

1

0

High-throughput

0.426

High

1394125

SUCB2
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

1

0

High-throughput

0.426

High

1309526

DAA19
Dynein axonemal assembly factor 19

2

0

High-throughput

0.328

High

1388159

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

2

0

High-throughput

0.316

High

1393350

OXND1
Oxidoreductase NAD-binding domain-containing protein 1

2

0

High-throughput

0.316

High

1396421

PHAR3
Phosphatase and actin regulator 3

2

0

High-throughput

0.316

High

231252

NDUS5
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

1

0

High-throughput

0.279

Low

377002

ANF
Natriuretic peptides A

1

0

High-throughput

0.279

Low

1094523

ZN154
Zinc finger protein 154

1

0

High-throughput

0.279

Low

1384082

TOM6
Mitochondrial import receptor subunit TOM6 homolog

1

0

High-throughput

0.279

Low

1396687

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.279

Low

1396691

TSSP
Thymus-specific serine protease

1

0

High-throughput

0.279

Low

1396695

THA10
THAP domain-containing protein 10

1

0

High-throughput

0.279

Low

505294

F153B
Protein FAM153B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025