Protein: CRBB3
Beta-crystallin B3 (Beta-B3 crystallin) [Cleaved into: Beta-crystallin B3, N-terminally processed]

Gene: CRBB3, CRYBB3
Organism: Homo sapiens
Interactions: 78
UniProt ID: P26998

Gene Ontology (top 5):
GO:0002088 - lens development in camera-type eye
GO:0005212 - structural constituent of eye lens
GO:0007601 - visual perception

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

437455

CRBA1
Beta-crystallin A3 [Cleaved into: Beta-crystallin A3, isoform A1, Delta4 form; Beta-crystallin A3, isoform A1, Delta7 form; Beta-crystallin A3, isoform A1, Delta8 form]

4

14

Small-scale

0.901

High

690003

CRBB3
Beta-crystallin B3

1

15

Small-scale

0.590

High

690009

CRBA2
Beta-crystallin A2

1

15

Small-scale

0.590

High

690010

CRBA4
Beta-crystallin A4

1

16

High-throughput

0.575

High

690011

CRBB1
Beta-crystallin B1

1

15

High-throughput

0.575

High

384368

CRYAA
Alpha-crystallin A chain

1

13

High-throughput

0.515

High

158978

ZN195
Zinc finger protein 195

1

1

High-throughput

0.489

High

161695

APAF
Apoptotic protease-activating factor 1

1

2

High-throughput

0.489

High

188181

HDAC3
Histone deacetylase 3

1

1

High-throughput

0.489

High

193750

PER1
Period circadian protein homolog 1

1

1

High-throughput

0.489

High

295725

AP1G2
AP-1 complex subunit gamma-like 2

1

1

High-throughput

0.489

High

331712

MTMR5
Myotubularin-related protein 5

1

1

High-throughput

0.489

High

690005

ETV3
ETS translocation variant 3

1

1

High-throughput

0.489

High

690015

STK4
Serine/threonine-protein kinase 4

1

1

High-throughput

0.489

High

690016

TRI32
E3 ubiquitin-protein ligase TRIM32

1

1

High-throughput

0.489

High

690017

RIN1
Ras and Rab interactor 1

1

1

High-throughput

0.489

High

690025

EIPR1
EARP and GARP complex-interacting protein 1

1

1

High-throughput

0.489

High

690029

MRCKG
Serine/threonine-protein kinase MRCK gamma

1

1

High-throughput

0.489

High

690030

PHLB3
Pleckstrin homology-like domain family B member 3

1

3

High-throughput

0.489

High

690034

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.489

High

690035

DNMBP
Dynamin-binding protein

1

1

High-throughput

0.489

High

690049

RAD50
DNA repair protein RAD50

1

1

High-throughput

0.489

High

690055

TF7L2
Transcription factor 7-like 2

1

1

High-throughput

0.489

High

690056

NALP2
NACHT, LRR and PYD domains-containing protein 2

1

1

High-throughput

0.489

High

690013

GRB2
Growth factor receptor-bound protein 2

1

1

High-throughput

0.437

High

690023

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

2

High-throughput

0.437

High

690042

SRRM1
Serine/arginine repetitive matrix protein 1

1

1

High-throughput

0.437

High

61429

VWA8
von Willebrand factor A domain-containing protein 8

1

1

High-throughput

0.407

High

690006

PI4KA
Phosphatidylinositol 4-kinase alpha

1

2

High-throughput

0.407

High

690007

HELZ
Probable helicase with zinc finger domain

1

1

High-throughput

0.407

High

690026

WDR81
WD repeat-containing protein 81

1

1

High-throughput

0.407

High

690021

MAJIN
Membrane-anchored junction protein

2

0

High-throughput

0.324

High

690033

DOK6
Docking protein 6

2

0

High-throughput

0.316

High

437475

CASB
Beta-casein

2

0

High-throughput

0.313

High

690048

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

2

0

High-throughput

0.313

High

67617

RHG32
Rho GTPase-activating protein 32

1

0

High-throughput

0.279

Low

298573

RAD17
Cell cycle checkpoint protein RAD17

1

0

High-throughput

0.279

Low

322369

HAUS5
HAUS augmin-like complex subunit 5

1

0

High-throughput

0.279

Low

339941

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

0

High-throughput

0.279

Low

521549

H14
Histone H1.4

1

0

High-throughput

0.279

Low

690004

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.279

Low

690008

KNTC1
Kinetochore-associated protein 1

1

0

High-throughput

0.279

Low

690014

ARHG5
Rho guanine nucleotide exchange factor 5

1

0

High-throughput

0.279

Low

690019

NAB2
NGFI-A-binding protein 2

1

0

High-throughput

0.279

Low

690022

RGL3
Ral guanine nucleotide dissociation stimulator-like 3

1

0

High-throughput

0.279

Low

690024

KLH26
Kelch-like protein 26

1

0

High-throughput

0.279

Low

690027

HAUS3
HAUS augmin-like complex subunit 3

1

0

High-throughput

0.279

Low

690028

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

0

High-throughput

0.279

Low

690031

ARMX5
Armadillo repeat-containing X-linked protein 5

1

0

High-throughput

0.279

Low

690032

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

1

0

High-throughput

0.279

Low

690037

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.279

Low

690038

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

0

High-throughput

0.279

Low

690039

MEX3D
RNA-binding protein MEX3D

1

0

High-throughput

0.279

Low

690040

IFNL1
Interferon lambda-1

1

0

High-throughput

0.279

Low

690041

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

0

High-throughput

0.279

Low

690043

TENS4
Tensin-4

1

0

High-throughput

0.279

Low

690045

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

High-throughput

0.279

Low

690046

KNL1
Outer kinetochore KNL1 complex subunit KNL1

1

0

High-throughput

0.279

Low

690047

P4K2B
Phosphatidylinositol 4-kinase type 2-beta

1

0

High-throughput

0.279

Low

690051

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

1

0

High-throughput

0.279

Low

690052

RPAP1
RNA polymerase II-associated protein 1

1

0

High-throughput

0.279

Low

690053

K1671
Uncharacterized protein KIAA1671

1

0

High-throughput

0.279

Low

690054

ESRP2
Epithelial splicing regulatory protein 2

1

0

High-throughput

0.279

Low

690057

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

0

High-throughput

0.279

Low

690058

ZNFX1
NFX1-type zinc finger-containing protein 1

1

0

High-throughput

0.279

Low

690059

TBK1
Serine/threonine-protein kinase TBK1

1

0

High-throughput

0.279

Low

690060

TTF2
Transcription termination factor 2

1

0

High-throughput

0.279

Low

690061

TBD2B
TBC1 domain family member 2B

1

0

High-throughput

0.279

Low

690062

PRG3
Proteoglycan 3

1

0

High-throughput

0.279

Low

690020

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

0

High-throughput

0.269

Low

280515

PR40A
Pre-mRNA-processing factor 40 homolog A

1

0

High-throughput

0.268

Low

561904

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.268

Low

690012

CASP6
Caspase-6

1

0

High-throughput

0.268

Low

690018

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.268

Low

690036

FA83H
Protein FAM83H

1

0

High-throughput

0.232

Low

690044

ARG28
Rho guanine nucleotide exchange factor 28

1

0

High-throughput

0.232

Low

690050

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025