Protein: IGHG4
Immunoglobulin heavy constant gamma 4 (Ig gamma-4 chain C region)

Gene: IGHG4
Organism: Homo sapiens
Interactions: 40
UniProt ID: P01861

Gene Ontology (top 5):
GO:0002250 - adaptive immune response
GO:0003823 - antigen binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

379058

IGKC
Immunoglobulin kappa constant

1

16

Small-scale

0.647

High

379175

IGHG1
Immunoglobulin heavy constant gamma 1

1

17

High-throughput

0.575

High

379450

HV431
Immunoglobulin heavy variable 4-31

1

17

High-throughput

0.575

High

379448

ALDH2
Aldehyde dehydrogenase, mitochondrial

2

6

High-throughput

0.552

High

379473

SNX27
Sorting nexin-27

2

9

High-throughput

0.504

High

194440

P2RX6
P2X purinoceptor 6

1

4

High-throughput

0.445

High

351632

SG1D1
Secretoglobin family 1D member 1

1

6

High-throughput

0.445

High

379452

AATC
Aspartate aminotransferase, cytoplasmic

1

7

High-throughput

0.445

High

379454

CCR1
C-C chemokine receptor type 1

1

13

High-throughput

0.445

High

379455

STAT6
Signal transducer and activator of transcription 6

1

2

Small-scale

0.437

High

379457

REL
Proto-oncogene c-Rel

1

2

Small-scale

0.437

High

379475

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.426

High

379449

H2AB1
Histone H2A-Bbd type 1

1

3

High-throughput

0.407

High

379451

ADT3
ADP/ATP translocase 3

1

5

High-throughput

0.407

High

379453

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

2

High-throughput

0.407

High

379456

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

9

High-throughput

0.407

High

379458

KAT1
Kynurenine--oxoglutarate transaminase 1

1

10

High-throughput

0.407

High

379459

UPP1
Uridine phosphorylase 1

1

3

High-throughput

0.407

High

379460

CR021
UPF0711 protein C18orf21

1

7

High-throughput

0.407

High

379461

EMC4
ER membrane protein complex subunit 4

1

3

High-throughput

0.407

High

379462

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

11

High-throughput

0.407

High

379463

CIR1
Corepressor interacting with RBPJ 1

1

7

High-throughput

0.407

High

379464

CERS3
Ceramide synthase 3

1

7

High-throughput

0.407

High

379465

NRSN1
Neurensin-1

1

6

High-throughput

0.407

High

379466

ARM10
Armadillo repeat-containing protein 10

1

1

High-throughput

0.407

High

379467

RHBL4
Rhomboid-related protein 4

1

8

High-throughput

0.407

High

379468

PIGT
GPI-anchor transamidase component PIGT

1

6

High-throughput

0.407

High

379469

R51A1
RAD51-associated protein 1

1

1

High-throughput

0.407

High

379470

SARAF
Store-operated calcium entry-associated regulatory factor

1

3

High-throughput

0.407

High

379471

EDC3
Enhancer of mRNA-decapping protein 3

1

1

High-throughput

0.407

High

379472

PDLI5
PDZ and LIM domain protein 5

1

3

High-throughput

0.407

High

379474

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

11

High-throughput

0.407

High

379476

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

8

High-throughput

0.407

High

379478

MO4L1
Mortality factor 4-like protein 1

1

2

High-throughput

0.407

High

379479

PHF11
PHD finger protein 11

1

11

High-throughput

0.407

High

379480

RN115
E3 ubiquitin-protein ligase RNF115

1

4

High-throughput

0.407

High

64677

ASPDH
Aspartate dehydrogenase domain-containing protein

1

0

High-throughput

0.232

Low

219792

CHSTA
Carbohydrate sulfotransferase 10

1

0

High-throughput

0.232

Low

348303

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.232

Low

379477

HYPK
Huntingtin-interacting protein K

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025