Protein: EDC3
Enhancer of mRNA-decapping protein 3 (LSM16 homolog) (YjeF N-terminal domain-containing protein 2) (YjeF_N2) (hYjeF_N2) (YjeF domain-containing protein 1)

Gene: EDC3
Organism: Homo sapiens
Interactions: 166
UniProt ID: Q96F86

Gene Ontology (top 5):
GO:0000932 - P-body
GO:0003729 - mRNA binding
GO:0005829 - cytosol
GO:0016020 - membrane
GO:0031087 - deadenylation-independent decapping of nuclear-transcribed mRNA

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

684350

DDX6
Probable ATP-dependent RNA helicase DDX6

16

2

Small-scale

0.987

High

1390393

EDC3
Enhancer of mRNA-decapping protein 3

6

2

Small-scale

0.951

High

1390411

DCP1A
mRNA-decapping enzyme 1A

15

3

Small-scale

0.764

High

1316181

DCP1B
mRNA-decapping enzyme 1B

13

3

Small-scale

0.763

High

966728

1433G
14-3-3 protein gamma

7

7

High-throughput

0.748

High

1306910

DCP2
m7GpppN-mRNA hydrolase

6

4

Small-scale

0.732

High

730138

1433B
14-3-3 protein beta/alpha

6

7

High-throughput

0.732

High

1049656

1433F
14-3-3 protein eta

5

7

High-throughput

0.718

High

691326

1433T
14-3-3 protein theta

5

7

High-throughput

0.706

High

1241485

EDC4
Enhancer of mRNA-decapping protein 4

6

0

Small-scale

0.705

High

990594

1433Z
14-3-3 protein zeta/delta

4

7

High-throughput

0.691

High

541050

PIM1
Serine/threonine-protein kinase pim-1

5

0

High-throughput

0.686

High

971869

1433E
14-3-3 protein epsilon

3

1

High-throughput

0.656

High

791626

SYUA
Alpha-synuclein

4

0

Small-scale

0.653

High

336742

BAG4
BAG family molecular chaperone regulator 4

3

0

High-throughput

0.646

High

1336271

LS14A
Protein LSM14 homolog A

3

1

Small-scale

0.640

High

253976

LPXN
Leupaxin

3

0

High-throughput

0.634

High

1094609

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

3

0

High-throughput

0.634

High

855920

CRKL
Crk-like protein

2

1

High-throughput

0.628

High

705505

GRN
Progranulin

2

0

High-throughput

0.602

High

688296

TTP
mRNA decay activator protein ZFP36

2

0

Small-scale

0.585

High

1390404

CARD9
Caspase recruitment domain-containing protein 9

2

0

High-throughput

0.585

High

730820

1433S
14-3-3 protein sigma

2

7

High-throughput

0.584

High

891731

GSK3B
Glycogen synthase kinase-3 beta

2

2

High-throughput

0.584

High

868228

SYQ
Glutamine--tRNA ligase

2

0

High-throughput

0.580

High

1390412

PNRC2
Proline-rich nuclear receptor coactivator 2

2

0

High-throughput

0.576

High

396695

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

855723

CRK
Adapter molecule crk

2

1

High-throughput

0.571

High

1287115

PATL1
Protein PAT1 homolog 1

2

1

Small-scale

0.571

High

242568

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

1311929

FBX16
F-box only protein 16

2

1

High-throughput

0.549

High

483185

CLCA
Clathrin light chain A

1

1

High-throughput

0.536

High

483381

CLCB
Clathrin light chain B

1

1

High-throughput

0.536

High

650903

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

2

High-throughput

0.536

High

922482

CLH2
Clathrin heavy chain 2

1

1

High-throughput

0.536

High

1026174

CLH1
Clathrin heavy chain 1

1

1

High-throughput

0.536

High

1370055

RENT1
Regulator of nonsense transcripts 1

1

2

Small-scale

0.536

High

66939

AQ12B
Putative aquaporin-12B

1

0

High-throughput

0.513

High

291853

STK16
Serine/threonine-protein kinase 16

1

0

High-throughput

0.513

High

384517

CRYAA
Alpha-crystallin A chain

1

0

High-throughput

0.513

High

941827

ARL4C
ADP-ribosylation factor-like protein 4C

1

0

High-throughput

0.513

High

1334763

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.513

High

1390407

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.513

High

1390417

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.513

High

1129925

KANK1
KN motif and ankyrin repeat domain-containing protein 1

1

1

High-throughput

0.489

High

1225041

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

1

High-throughput

0.489

High

185925

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

173215

XPO1
Exportin-1

1

2

High-throughput

0.479

High

281391

GGYF1
GRB10-interacting GYF protein 1

1

1

High-throughput

0.479

High

323523

TRI37
E3 ubiquitin-protein ligase TRIM37

1

1

High-throughput

0.479

High

550409

PABP1
Polyadenylate-binding protein 1

1

1

High-throughput

0.479

High

891280

GSK3A
Glycogen synthase kinase-3 alpha

1

2

High-throughput

0.479

High

1025581

CDK16
Cyclin-dependent kinase 16

1

1

High-throughput

0.479

High

1102058

PABP4
Polyadenylate-binding protein 4

1

1

High-throughput

0.479

High

1275606

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

1

High-throughput

0.479

High

1316430

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.479

High

1324911

RHG18
Rho GTPase-activating protein 18

1

1

High-throughput

0.479

High

1336817

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

1

High-throughput

0.479

High

1359577

ATX2L
Ataxin-2-like protein

1

1

High-throughput

0.479

High

1390401

ATX2
Ataxin-2

1

1

High-throughput

0.479

High

1390403

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

2

High-throughput

0.479

High

1390409

MOV10
Helicase MOV-10

1

2

High-throughput

0.479

High

1390428

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

2

High-throughput

0.479

High

64894

RCCD1
RCC1 domain-containing protein 1

1

0

High-throughput

0.458

High

188019

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

0

Small-scale

0.458

High

252140

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

269594

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

0

High-throughput

0.458

High

346181

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

643023

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.458

High

700705

PSA5
Proteasome subunit alpha type-5

1

0

Small-scale

0.458

High

714347

PML
Protein PML

1

0

High-throughput

0.458

High

719254

MPIP2
M-phase inducer phosphatase 2

1

0

High-throughput

0.458

High

831229

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

964705

DCAF7
DDB1- and CUL4-associated factor 7

1

0

High-throughput

0.458

High

970911

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

1045634

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1067594

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

1108033

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

1113974

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1134027

ZN638
Zinc finger protein 638

1

0

High-throughput

0.458

High

1149348

STIL
SCL-interrupting locus protein

1

0

High-throughput

0.458

High

1208402

WIPI1
WD repeat domain phosphoinositide-interacting protein 1

1

0

Small-scale

0.458

High

1208566

SMAG2
Protein Smaug homolog 2

1

0

High-throughput

0.458

High

1216080

SPD2A
SH3 and PX domain-containing protein 2A

1

0

High-throughput

0.458

High

1220727

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

1252363

MEX3B
RNA-binding protein MEX3B

1

0

High-throughput

0.458

High

1280716

YTHD3
YTH domain-containing family protein 3

1

0

High-throughput

0.458

High

1289531

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1309234

KSR1
Kinase suppressor of Ras 1

1

0

High-throughput

0.458

High

1339653

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

1352599

DEN1A
DENN domain-containing protein 1A

1

0

High-throughput

0.458

High

1363941

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

1368929

GOGA1
Golgin subfamily A member 1

1

0

High-throughput

0.458

High

1384753

ARL8A
ADP-ribosylation factor-like protein 8A

1

0

High-throughput

0.458

High

1390396

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

1390398

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.458

High

1390405

VP33B
Vacuolar protein sorting-associated protein 33B

1

0

High-throughput

0.458

High

1390415

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.458

High

1390420

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1390421

LIMA1
LIM domain and actin-binding protein 1

1

0

High-throughput

0.458

High

1390424

AGO2
Protein argonaute-2

1

0

High-throughput

0.458

High

1390426

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.458

High

1390429

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

0

High-throughput

0.458

High

1390430

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.458

High

1390431

MARF1
Meiosis regulator and mRNA stability factor 1

1

0

High-throughput

0.458

High

1390434

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

0

High-throughput

0.458

High

1234907

PKHA7
Pleckstrin homology domain-containing family A member 7

1

1

High-throughput

0.445

High

1165488

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

3

High-throughput

0.437

High

1257031

SYDE1
Rho GTPase-activating protein SYDE1

1

1

High-throughput

0.437

High

1276630

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

1360388

SRS12
Serine/arginine-rich splicing factor 12

1

2

High-throughput

0.437

High

1367000

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

1368050

HDAC2
Histone deacetylase 2

1

1

High-throughput

0.437

High

1390399

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

1

High-throughput

0.437

High

1390406

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

3679

NBDY
Negative regulator of P-body association

1

0

Small-scale

0.426

High

62575

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.426

High

369197

OAS1
2'-5'-oligoadenylate synthase 1

1

0

High-throughput

0.426

High

1209503

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1358827

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

0

High-throughput

0.426

High

1390397

CEP63
Centrosomal protein of 63 kDa

1

0

High-throughput

0.426

High

1390402

INP5K
Inositol polyphosphate 5-phosphatase K

1

0

High-throughput

0.426

High

379293

IGHG1
Immunoglobulin heavy constant gamma 1

1

1

High-throughput

0.407

High

379471

IGHG4
Immunoglobulin heavy constant gamma 4

1

1

High-throughput

0.407

High

1390423

ANX10
Annexin A10

6

0

High-throughput

0.385

High

1206419

EFHC2
EF-hand domain-containing family member C2

4

0

High-throughput

0.368

High

210772

KLK10
Kallikrein-10

3

0

High-throughput

0.347

High

1390418

TAP26
Thyroid transcription factor 1-associated protein 26

2

0

High-throughput

0.328

High

297849

PIAS2
E3 SUMO-protein ligase PIAS2

2

0

High-throughput

0.316

High

1348417

LNX1
E3 ubiquitin-protein ligase LNX

2

0

High-throughput

0.316

High

928891

LIPR2
Pancreatic lipase-related protein 2

2

0

High-throughput

0.313

High

1390395

F167A
Protein FAM167A

2

0

High-throughput

0.313

High

1390425

PNMA2
Paraneoplastic antigen Ma2

2

0

High-throughput

0.313

High

683648

ITB8
Integrin beta-8

1

0

High-throughput

0.279

Low

932926

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

0

High-throughput

0.279

Low

1228698

C102B
Coiled-coil domain-containing protein 102B

1

0

High-throughput

0.279

Low

1347039

G45IP
Large ribosomal subunit protein mL64

1

0

High-throughput

0.279

Low

1347491

PPR35
Protein phosphatase 1 regulatory subunit 35

1

0

High-throughput

0.279

Low

1390408

PAAT
ATPase PAAT

1

0

High-throughput

0.279

Low

1390422

F153A
Protein FAM153A

1

0

High-throughput

0.279

Low

1390433

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.279

Low

106449

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

176860

DCLK1
Serine/threonine-protein kinase DCLK1

1

0

High-throughput

0.249

Low

208716

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

0

High-throughput

0.249

Low

218617

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

260291

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low

294165

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

412423

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

589396

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

590931

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.249

Low

768874

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1149960

TERF2
Telomeric repeat-binding factor 2

1

0

High-throughput

0.249

Low

1187063

LSM12
Protein LSM12

1

0

High-throughput

0.249

Low

1255030

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1314359

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.249

Low

1390394

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.249

Low

1390400

TESK2
Dual specificity testis-specific protein kinase 2

1

0

High-throughput

0.249

Low

1390410

Q9HCK3
KIAA1569 protein

1

0

High-throughput

0.249

Low

1390414

KI13B
Kinesin-like protein KIF13B

1

0

High-throughput

0.249

Low

1390419

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.249

Low

1390427

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

0

High-throughput

0.249

Low

1390432

KCTD3
BTB/POZ domain-containing protein KCTD3

1

0

High-throughput

0.249

Low

1258538

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

0

High-throughput

0.232

Low

1390413

HINT3
Adenosine 5'-monophosphoramidase HINT3

1

0

High-throughput

0.232

Low

1390416

CAH10
Carbonic anhydrase-related protein 10

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025