Protein: HYPK
Huntingtin-interacting protein K (Huntingtin yeast partner K)

Gene: HYPK
Organism: Homo sapiens
Interactions: 99
UniProt ID: Q9NX55

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0015630 - microtubule cytoskeleton
GO:0032991 - protein-containing complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1416885

NAA15
N-alpha-acetyltransferase 15, NatA auxiliary subunit

10

3

Small-scale

0.756

High

833694

NAA10
N-alpha-acetyltransferase 10

5

4

Small-scale

0.718

High

1236182

NAA16
N-alpha-acetyltransferase 16, NatA auxiliary subunit

3

3

High-throughput

0.662

High

844033

HD
Huntingtin

4

0

Small-scale

0.653

High

821212

TXLNA
Alpha-taxilin

3

0

High-throughput

0.646

High

1429166

NAA50
N-alpha-acetyltransferase 50

2

4

High-throughput

0.601

High

949214

TPIS
Triosephosphate isomerase

2

0

Small-scale

0.585

High

423315

A4
Amyloid-beta precursor protein

2

0

Small-scale

0.569

High

1407115

MDFI
MyoD family inhibitor

2

0

Small-scale

0.561

High

1410992

RHXF2
Rhox homeobox family member 2

2

0

Small-scale

0.561

High

848186

MAGA1
Melanoma-associated antigen 1

1

0

High-throughput

0.549

High

1154942

NEDD8
Ubiquitin-like protein NEDD8

1

0

Small-scale

0.537

High

1412920

NAA11
N-alpha-acetyltransferase 11

1

4

High-throughput

0.536

High

387332

APOA1
Apolipoprotein A-I

1

0

High-throughput

0.513

High

419238

H2A1B
Histone H2A type 1-B/E

1

0

High-throughput

0.513

High

1451797

YETS2
YEATS domain-containing protein 2

1

0

High-throughput

0.513

High

1428390

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

3

Small-scale

0.512

High

1287084

ALPK2
Alpha-protein kinase 2

1

1

High-throughput

0.489

High

1036864

SP4
Transcription factor Sp4

1

1

High-throughput

0.481

High

177068

CE290
Centrosomal protein of 290 kDa

1

1

Small-scale

0.479

High

359758

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

1

Small-scale

0.479

High

801560

HSPA9
Stress-70 protein, mitochondrial

1

1

Small-scale

0.479

High

946206

MLF1
Myeloid leukemia factor 1

1

1

Small-scale

0.479

High

952364

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

3

Small-scale

0.479

High

1081657

HSP7E
Heat shock 70 kDa protein 14

1

1

Small-scale

0.479

High

1123842

DCTN1
Dynactin subunit 1

1

1

High-throughput

0.479

High

1153604

MLF2
Myeloid leukemia factor 2

1

1

Small-scale

0.479

High

1405146

DNJC2
DnaJ homolog subfamily C member 2

1

1

Small-scale

0.479

High

330346

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.460

High

913070

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

0

High-throughput

0.460

High

995306

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.460

High

1146848

PCBP1
Poly(rC)-binding protein 1

1

0

High-throughput

0.460

High

1332309

BOLL
Protein boule-like

1

0

High-throughput

0.460

High

1336936

PHC3
Polyhomeotic-like protein 3

1

0

High-throughput

0.460

High

1394307

TET5A
Terminal nucleotidyltransferase 5A

1

0

High-throughput

0.460

High

1450890

THAP1
THAP domain-containing protein 1

1

0

High-throughput

0.460

High

1451150

RFOX1
RNA binding protein fox-1 homolog 1

1

0

High-throughput

0.460

High

270740

N4BP1
NEDD4-binding protein 1

1

0

Small-scale

0.458

High

273720

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

0

Small-scale

0.458

High

320783

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.458

High

390307

VTDB
Vitamin D-binding protein

1

0

Small-scale

0.458

High

414724

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

415897

HSPB1
Heat shock protein beta-1

1

0

Small-scale

0.458

High

468852

HS90B
Heat shock protein HSP 90-beta

1

0

Small-scale

0.458

High

475026

VIME
Vimentin

1

0

Small-scale

0.458

High

538008

HSP7C
Heat shock cognate 71 kDa protein

1

0

Small-scale

0.458

High

562444

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

Small-scale

0.458

High

607159

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

612800

RL7
Large ribosomal subunit protein uL30

1

0

Small-scale

0.458

High

616239

PGAM1
Phosphoglycerate mutase 1

1

0

Small-scale

0.458

High

648242

NDKB
Nucleoside diphosphate kinase B

1

0

Small-scale

0.458

High

698048

CALR
Calreticulin

1

0

Small-scale

0.458

High

776863

MYH11
Myosin-11

1

0

High-throughput

0.458

High

930804

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

0

High-throughput

0.458

High

937560

CAD11
Cadherin-11

1

0

Small-scale

0.458

High

960588

PSME3
Proteasome activator complex subunit 3

1

0

Small-scale

0.458

High

996366

EF1A1
Elongation factor 1-alpha 1

1

0

Small-scale

0.458

High

1026561

HSF1
Heat shock factor protein 1

1

0

Small-scale

0.458

High

1045838

TF65
Transcription factor p65

1

0

Small-scale

0.458

High

1088585

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

0

Small-scale

0.458

High

1117314

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.458

High

1126772

BECN1
Beclin-1

1

0

Small-scale

0.458

High

1131842

LBR
Delta(14)-sterol reductase LBR

1

0

Small-scale

0.458

High

1138694

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1278936

BRAP
BRCA1-associated protein

1

0

High-throughput

0.458

High

1312171

NELFD
Negative elongation factor C/D

1

0

Small-scale

0.458

High

1315303

ZN100
Zinc finger protein 100

1

0

Small-scale

0.458

High

1365816

ZN516
Zinc finger protein 516

1

0

Small-scale

0.458

High

1372105

RBPMS
RNA-binding protein with multiple splicing

1

0

Small-scale

0.458

High

1395188

ZN462
Zinc finger protein 462

1

0

Small-scale

0.458

High

1400083

QKI
KH domain-containing RNA-binding protein QKI

1

0

Small-scale

0.458

High

1400261

LENG8
Leukocyte receptor cluster member 8

1

0

Small-scale

0.458

High

1400618

KI20B
Kinesin-like protein KIF20B

1

0

Small-scale

0.458

High

1417199

SRRT
Serrate RNA effector molecule homolog

1

0

Small-scale

0.458

High

1419115

KRA33
Keratin-associated protein 3-3

1

1

High-throughput

0.439

High

1419124

KRA32
Keratin-associated protein 3-2

1

1

High-throughput

0.439

High

883478

DHE4
Glutamate dehydrogenase 2, mitochondrial

1

1

Small-scale

0.437

High

1042090

LMNB2
Lamin-B2

1

1

Small-scale

0.437

High

1430344

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

3

Small-scale

0.437

High

1433216

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

3

Small-scale

0.437

High

47587

RPSA2
Small ribosomal subunit protein uS2B

1

0

High-throughput

0.426

High

1136504

FL2D
Pre-mRNA-splicing regulator WTAP

1

0

High-throughput

0.426

High

1187696

T10IP
Testis-specific protein 10-interacting protein

3

0

High-throughput

0.347

High

1179268

CB068
UPF0561 protein C2orf68

2

0

High-throughput

0.316

High

939833

ATPK
ATP synthase F(0) complex subunit f, mitochondrial

1

0

High-throughput

0.279

Low

70511

CRTP1
Cysteine-rich tail protein 1

1

0

High-throughput

0.251

Low

948397

KR122
Keratin-associated protein 12-2

1

0

High-throughput

0.251

Low

1017758

PR20A
Proline-rich protein 20A

1

0

High-throughput

0.251

Low

1186922

KR195
Keratin-associated protein 19-5

1

0

High-throughput

0.251

Low

1307099

KRA81
Keratin-associated protein 8-1

1

0

High-throughput

0.251

Low

254649

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.249

Low

793777

ETFB
Electron transfer flavoprotein subunit beta

1

0

High-throughput

0.249

Low

873335

COPD
Coatomer subunit delta

1

0

Small-scale

0.249

Low

1217945

MYOM3
Myomesin-3

1

0

Small-scale

0.249

Low

1258698

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

0

Small-scale

0.249

Low

1359394

DNJB3
DnaJ homolog subfamily B member 3

1

0

Small-scale

0.249

Low

1372168

SBP2L
Selenocysteine insertion sequence-binding protein 2-like

1

0

High-throughput

0.249

Low

1438150

VPP4
V-type proton ATPase 116 kDa subunit a 4

1

0

Small-scale

0.249

Low

379477

IGHG4
Immunoglobulin heavy constant gamma 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025