Protein: DNS2B
Deoxyribonuclease-2-beta (EC 3.1.22.1) (DNase II-like acid DNase) (DNase2-like acid DNase) (Deoxyribonuclease II beta) (DNase II beta) (Endonuclease DLAD)

Gene: DNS2B, DNASE2B
Organism: Homo sapiens
Interactions: 52
UniProt ID: Q8WZ79

Gene Ontology (top 5):
GO:0004531 - deoxyribonuclease II activity
GO:0005576 - extracellular region
GO:0005764 - lysosome
GO:0006309 - apoptotic DNA fragmentation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

756575

GALNS
N-acetylgalactosamine-6-sulfatase

3

1

High-throughput

0.667

High

1362046

I17RA
Interleukin-17 receptor A

4

0

High-throughput

0.661

High

582351

ARSA
Arylsulfatase A

2

1

High-throughput

0.628

High

1087070

FSTL1
Follistatin-related protein 1

3

0

High-throughput

0.622

High

997059

TBA4A
Tubulin alpha-4A chain

2

1

High-throughput

0.611

High

1131691

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

3

2

High-throughput

0.609

High

1158070

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

3

2

High-throughput

0.609

High

1360632

AGRV1
Adhesion G-protein coupled receptor V1

3

2

High-throughput

0.609

High

1143763

PON2
Serum paraoxonase/arylesterase 2

2

0

High-throughput

0.602

High

462906

LAMB1
Laminin subunit beta-1

1

0

High-throughput

0.513

High

932383

ANAG
Alpha-N-acetylglucosaminidase

1

0

High-throughput

0.513

High

606020

CAN2
Calpain-2 catalytic subunit

1

0

High-throughput

0.458

High

1362050

CECR2
Chromatin remodeling regulator CECR2

1

0

High-throughput

0.458

High

174575

TRI66
Tripartite motif-containing protein 66

1

3

High-throughput

0.437

High

180883

TIF1A
Transcription intermediary factor 1-alpha

1

2

High-throughput

0.437

High

1127585

FAT1
Protocadherin Fat 1

1

1

High-throughput

0.437

High

1211490

FREM2
FRAS1-related extracellular matrix protein 2

1

4

High-throughput

0.437

High

1259387

TBA1A
Tubulin alpha-1A chain

1

1

High-throughput

0.437

High

1333180

AFG2A
ATPase family gene 2 protein homolog A

1

1

High-throughput

0.437

High

1362054

SP110
Sp110 nuclear body protein

1

2

High-throughput

0.437

High

449572

HEXA
Beta-hexosaminidase subunit alpha

1

0

High-throughput

0.426

High

1362052

DSN1
Kinetochore-associated protein DSN1 homolog

1

0

High-throughput

0.426

High

1103137

2A5G
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

1

2

High-throughput

0.407

High

1250381

PCD23
Protocadherin-23

1

1

High-throughput

0.407

High

1175820

T132A
Transmembrane protein 132A

3

0

High-throughput

0.347

High

1193204

OFUT4
GDP-fucose protein O-fucosyltransferase 4

3

0

High-throughput

0.347

High

1208399

WIPI1
WD repeat domain phosphoinositide-interacting protein 1

3

0

High-throughput

0.347

High

1362051

YTHD1
YTH domain-containing family protein 1

3

0

High-throughput

0.347

High

1362053

TOR3A
Torsin-3A

3

0

High-throughput

0.347

High

1362057

SUCO
SUN domain-containing ossification factor

3

0

High-throughput

0.347

High

515721

TPC2B
Trafficking protein particle complex subunit 2B

3

0

High-throughput

0.334

High

607704

DCAM
S-adenosylmethionine decarboxylase proenzyme

2

0

High-throughput

0.318

High

1212678

GT253
Inactive glycosyltransferase 25 family member 3

2

0

High-throughput

0.318

High

1362047

PASK
PAS domain-containing serine/threonine-protein kinase

2

0

High-throughput

0.318

High

1286288

GALT7
N-acetylgalactosaminyltransferase 7

2

0

High-throughput

0.298

High

274904

LRP5
Low-density lipoprotein receptor-related protein 5

1

0

High-throughput

0.279

Low

1108639

TBB3
Tubulin beta-3 chain

1

0

High-throughput

0.279

Low

1362056

TXD16
Thioredoxin domain-containing protein 16

1

0

High-throughput

0.279

Low

508357

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.261

Low

136627

MANBA
Beta-mannosidase

1

0

High-throughput

0.249

Low

547180

PYC
Pyruvate carboxylase, mitochondrial

1

0

High-throughput

0.249

Low

783357

TRI23
E3 ubiquitin-protein ligase TRIM23

1

0

High-throughput

0.249

Low

1085686

TBL3
Transducin beta-like protein 3

1

0

High-throughput

0.249

Low

1090824

TRAF2
TNF receptor-associated factor 2

1

0

High-throughput

0.249

Low

1107439

BIRC2
Baculoviral IAP repeat-containing protein 2

1

0

High-throughput

0.249

Low

1179117

TECT1
Tectonic-1

1

0

High-throughput

0.249

Low

1257530

TMTC3
Protein O-mannosyl-transferase TMTC3

1

0

High-throughput

0.249

Low

592678

ITB4
Integrin beta-4

1

0

High-throughput

0.232

Low

1244627

GASP3
G protein-coupled receptor associated sorting protein 3

1

0

High-throughput

0.232

Low

1362048

METH
Methionine synthase

1

0

High-throughput

0.232

Low

1362049

TCF25
Ribosome quality control complex subunit TCF25

1

0

High-throughput

0.232

Low

1362055

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025